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TRP Channels as Lower Urinary Tract Sensory Targets.
Med Sci (Basel). 2019 May 22; 7(5)MS

Abstract

Several members of the transient receptor potential (TRP) superfamily, including TRPV1, TRPV2, TRPV4, TRM4, TRPM8 and TRPA1, are expressed in the lower urinary tract (LUT), not only in neuronal fibers innervating the bladder and urethra, but also in the urothelial and muscular layers of the bladder and urethral walls. In the LUT, TRP channels are mainly involved in nociception and mechanosensory transduction. Animal studies have suggested the therapeutic potential of several TRP channels for the treatment of both bladder over- and underactivity and bladder pain disorders,; however translation of this finding to clinical application has been slow and the involvement of these channels in normal human bladder function, and in various pathologic states have not been established. The development of selective TRP channel agonists and antagonists is ongoing and the use of such agents can be expected to offer new and important information concerning both normal physiological functions and possible therapeutic applications.

Authors+Show Affiliations

Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA. karl-erik.andersson@med.lu.se. Institute of Laboratory Medicine, Lund University, 223 62 Lund, Sweden. karl-erik.andersson@med.lu.se.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31121962

Citation

Andersson, Karl-Erik. "TRP Channels as Lower Urinary Tract Sensory Targets." Medical Sciences (Basel, Switzerland), vol. 7, no. 5, 2019.
Andersson KE. TRP Channels as Lower Urinary Tract Sensory Targets. Med Sci (Basel). 2019;7(5).
Andersson, K. E. (2019). TRP Channels as Lower Urinary Tract Sensory Targets. Medical Sciences (Basel, Switzerland), 7(5). https://doi.org/10.3390/medsci7050067
Andersson KE. TRP Channels as Lower Urinary Tract Sensory Targets. Med Sci (Basel). 2019 May 22;7(5) PubMed PMID: 31121962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP Channels as Lower Urinary Tract Sensory Targets. A1 - Andersson,Karl-Erik, Y1 - 2019/05/22/ PY - 2019/04/18/received PY - 2019/05/19/revised PY - 2019/05/20/accepted PY - 2019/5/25/entrez PY - 2019/5/28/pubmed PY - 2019/5/28/medline KW - TRPM8 and TRPA1 KW - TRPV1 KW - TRPV2 KW - TRPV4 KW - bladder KW - lower urinary tract KW - urethra JF - Medical sciences (Basel, Switzerland) JO - Med Sci (Basel) VL - 7 IS - 5 N2 - Several members of the transient receptor potential (TRP) superfamily, including TRPV1, TRPV2, TRPV4, TRM4, TRPM8 and TRPA1, are expressed in the lower urinary tract (LUT), not only in neuronal fibers innervating the bladder and urethra, but also in the urothelial and muscular layers of the bladder and urethral walls. In the LUT, TRP channels are mainly involved in nociception and mechanosensory transduction. Animal studies have suggested the therapeutic potential of several TRP channels for the treatment of both bladder over- and underactivity and bladder pain disorders,; however translation of this finding to clinical application has been slow and the involvement of these channels in normal human bladder function, and in various pathologic states have not been established. The development of selective TRP channel agonists and antagonists is ongoing and the use of such agents can be expected to offer new and important information concerning both normal physiological functions and possible therapeutic applications. SN - 2076-3271 UR - https://www.unboundmedicine.com/medline/citation/31121962/TRP_Channels_as_Lower_Urinary_Tract_Sensory_Targets_ L2 - https://www.mdpi.com/resolver?pii=medsci7050067 DB - PRIME DP - Unbound Medicine ER -
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