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Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD.
BMC Pulm Med. 2019 05 21; 19(1):97.BP

Abstract

BACKGROUND

Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are understudied.

METHODS

The National Health and Nutrition Examination Survey (NHANES), with a focus on dietary assessment, provides a unique opportunity to explore relationships between omega-3 intake and morbidity in respiratory diseases marked by inflammation in the United States (US) population. We investigated relationships between ALA or EPA + DHA intake and respiratory symptoms among US adults with COPD, as well as variation in relationships based on personal characteristics or exposures.

RESULTS

Of 878 participants, mean age was 60.6 years, 48% were current smokers, and 68% completed high school. Omega-3 intake was, 1.71 ± 0.89 g (ALA), and 0.11 ± 0.21 g (EPA + DHA). Logistic regression models, adjusting for age, gender, race, body mass index, FEV1, education, smoking status, pack-years, total caloric intake, and omega-6 (linoleic acid, LA) intake demonstrated no primary associations between omega-3 intake and respiratory symptoms. Interaction terms were used to determine potential modification of relationships by personal characteristics (race, gender, education) or exposures (LA intake, smoking status), demonstrating that at lower levels of LA intake, increasing ALA intake was associated with reduced odds of chronic cough (pint = 0.015) and wheeze (pint = 0.037). EPA + DHA, but not ALA, was associated with reduced symptoms only among current smokers who did not complete high school.

CONCLUSIONS

Individual factors should be taken into consideration when studying the association of fatty acid intake on respiratory diseases, as differential responses may reveal susceptible subgroups.

Authors+Show Affiliations

Johns Hopkins University School of Medicine, Baltimore, MD, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA.University of Nebraska Medical Center, Omaha, NE, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA. Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA.Johns Hopkins University School of Medicine, Baltimore, MD, USA. nhansel1@jhmi.edu. Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. nhansel1@jhmi.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31122230

Citation

Lemoine S, Chantal M., et al. "Omega-3 Fatty Acid Intake and Prevalent Respiratory Symptoms Among U.S. Adults With COPD." BMC Pulmonary Medicine, vol. 19, no. 1, 2019, p. 97.
Lemoine S CM, Brigham EP, Woo H, et al. Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD. BMC Pulm Med. 2019;19(1):97.
Lemoine S, C. M., Brigham, E. P., Woo, H., Hanson, C. K., McCormack, M. C., Koch, A., Putcha, N., & Hansel, N. N. (2019). Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD. BMC Pulmonary Medicine, 19(1), 97. https://doi.org/10.1186/s12890-019-0852-4
Lemoine S CM, et al. Omega-3 Fatty Acid Intake and Prevalent Respiratory Symptoms Among U.S. Adults With COPD. BMC Pulm Med. 2019 05 21;19(1):97. PubMed PMID: 31122230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acid intake and prevalent respiratory symptoms among U.S. adults with COPD. AU - Lemoine S,Chantal M, AU - Brigham,Emily P, AU - Woo,Han, AU - Hanson,Corrine K, AU - McCormack,Meredith C, AU - Koch,Abigail, AU - Putcha,Nirupama, AU - Hansel,Nadia N, Y1 - 2019/05/21/ PY - 2019/01/05/received PY - 2019/04/25/accepted PY - 2019/5/25/entrez PY - 2019/5/28/pubmed PY - 2019/12/18/medline KW - COPD KW - Education KW - Fatty acid KW - Omega KW - Smoking SP - 97 EP - 97 JF - BMC pulmonary medicine JO - BMC Pulm Med VL - 19 IS - 1 N2 - BACKGROUND: Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been linked to decreased morbidity in several diseases, though effects on respiratory diseases like COPD are understudied. METHODS: The National Health and Nutrition Examination Survey (NHANES), with a focus on dietary assessment, provides a unique opportunity to explore relationships between omega-3 intake and morbidity in respiratory diseases marked by inflammation in the United States (US) population. We investigated relationships between ALA or EPA + DHA intake and respiratory symptoms among US adults with COPD, as well as variation in relationships based on personal characteristics or exposures. RESULTS: Of 878 participants, mean age was 60.6 years, 48% were current smokers, and 68% completed high school. Omega-3 intake was, 1.71 ± 0.89 g (ALA), and 0.11 ± 0.21 g (EPA + DHA). Logistic regression models, adjusting for age, gender, race, body mass index, FEV1, education, smoking status, pack-years, total caloric intake, and omega-6 (linoleic acid, LA) intake demonstrated no primary associations between omega-3 intake and respiratory symptoms. Interaction terms were used to determine potential modification of relationships by personal characteristics (race, gender, education) or exposures (LA intake, smoking status), demonstrating that at lower levels of LA intake, increasing ALA intake was associated with reduced odds of chronic cough (pint = 0.015) and wheeze (pint = 0.037). EPA + DHA, but not ALA, was associated with reduced symptoms only among current smokers who did not complete high school. CONCLUSIONS: Individual factors should be taken into consideration when studying the association of fatty acid intake on respiratory diseases, as differential responses may reveal susceptible subgroups. SN - 1471-2466 UR - https://www.unboundmedicine.com/medline/citation/31122230/Omega_3_fatty_acid_intake_and_prevalent_respiratory_symptoms_among_U_S__adults_with_COPD_ L2 - https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-0852-4 DB - PRIME DP - Unbound Medicine ER -