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Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update.
Ecancermedicalscience 2019; 13:909E

Abstract

Vasomotor symptoms, particularly hot flushes (HFs), are the most frequently reported symptom by menopausal women. In particular, for young women diagnosed with breast cancer, who experience premature ovarian failure due to cancer treatments, severe HFs are an unsolved problem that strongly impacts on quality of life. The optimal management of HFs requires a personalised approach to identify the treatment with the best benefit/risk profile for each woman. Hormonal replacement therapy (HRT) is effective in managing HFs but it is contraindicated in women with previous hormone-dependent cancer. Moreover, many healthy women are reluctant to take HRT and prefer to manage symptoms with non-hormonal strategies. In this narrative review, we provide an update on the current available non-oestrogenic strategies for HFs management for women who cannot, or do not wish to, take oestrogens. Since isoflavones have oestrogenic properties and it is not known if they can be safely consumed by women with previous hormone-dependent cancer, they were excluded. Selective serotonin reuptake inhibitors/selective serotonin-norepinephrine reuptake inhibitors, as well as other neuroactive agents, some herbal remedies and behavioural strategies are considered.

Authors+Show Affiliations

Division of Gynecology and Obstetrics, Department of Surgical Sciences, School of Medicine, University of Torino, Largo Turati 62, 10128 Torino, Italy.Division of Gynecology and Obstetrics, Department of Surgical Sciences, School of Medicine, University of Torino, Largo Turati 62, 10128 Torino, Italy.Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', University of Trieste, via dell'Istria 65/1, 34137 Trieste, Italy.Department of Woman and Child Health, Policlinico Gemelli Foundation, Largo Gemelli 1, 00168 Rome, Italy.Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, IRCCS S Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Viale Camillo Golgi 19, 27100 Pavia, Italy.Department of Obstetrics and Gynecology, Department of Surgical Sciences, University of Cagliari, University Hospital of Cagliari, SS 554 km 4,500, 09042 Monserrato, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31123492

Citation

Biglia, Nicoletta, et al. "Non-hormonal Strategies for Managing Menopausal Symptoms in Cancer Survivors: an Update." Ecancermedicalscience, vol. 13, 2019, p. 909.
Biglia N, Bounous VE, De Seta F, et al. Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update. Ecancermedicalscience. 2019;13:909.
Biglia, N., Bounous, V. E., De Seta, F., Lello, S., Nappi, R. E., & Paoletti, A. M. (2019). Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update. Ecancermedicalscience, 13, p. 909. doi:10.3332/ecancer.2019.909.
Biglia N, et al. Non-hormonal Strategies for Managing Menopausal Symptoms in Cancer Survivors: an Update. Ecancermedicalscience. 2019;13:909. PubMed PMID: 31123492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update. AU - Biglia,Nicoletta, AU - Bounous,Valentina E, AU - De Seta,Francesco, AU - Lello,Stefano, AU - Nappi,Rossella E, AU - Paoletti,Anna Maria, Y1 - 2019/03/11/ PY - 2018/10/09/received PY - 2019/5/25/entrez PY - 2019/5/28/pubmed PY - 2019/5/28/medline KW - hot flushes KW - menopause KW - non-hormonal therapies KW - non-oestrogenic therapies KW - vasomotor symptoms SP - 909 EP - 909 JF - Ecancermedicalscience JO - Ecancermedicalscience VL - 13 N2 - Vasomotor symptoms, particularly hot flushes (HFs), are the most frequently reported symptom by menopausal women. In particular, for young women diagnosed with breast cancer, who experience premature ovarian failure due to cancer treatments, severe HFs are an unsolved problem that strongly impacts on quality of life. The optimal management of HFs requires a personalised approach to identify the treatment with the best benefit/risk profile for each woman. Hormonal replacement therapy (HRT) is effective in managing HFs but it is contraindicated in women with previous hormone-dependent cancer. Moreover, many healthy women are reluctant to take HRT and prefer to manage symptoms with non-hormonal strategies. In this narrative review, we provide an update on the current available non-oestrogenic strategies for HFs management for women who cannot, or do not wish to, take oestrogens. Since isoflavones have oestrogenic properties and it is not known if they can be safely consumed by women with previous hormone-dependent cancer, they were excluded. Selective serotonin reuptake inhibitors/selective serotonin-norepinephrine reuptake inhibitors, as well as other neuroactive agents, some herbal remedies and behavioural strategies are considered. SN - 1754-6605 UR - https://www.unboundmedicine.com/medline/citation/31123492/Non_hormonal_strategies_for_managing_menopausal_symptoms_in_cancer_survivors:_an_update_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31123492/ DB - PRIME DP - Unbound Medicine ER -