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Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea.
Medicine (Baltimore). 2019 May; 98(21):e15756.M

Abstract

Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown.We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications.Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012-December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups.A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT3 serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups.Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon.Department of Obstetrics and Gynecology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Gyeonggido.Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon.Department of Obstetrics and Gynecology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul.Division of Infectious Diseases, Department of Internal Medicine, Seoul St, Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul.Department of Obstetrics and Gynecology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul.Department of Obstetrics and Gynecology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon.Department of Obstetrics and Gynecology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Gyeonggido.Department of Obstetrics and Gynecology, Seoul St, Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea .

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31124960

Citation

Choi, Sae Kyung, et al. "Opioid Analgesics Are the Leading Cause of Adverse Drug Reactions in the Obstetric Population in South Korea." Medicine, vol. 98, no. 21, 2019, pp. e15756.
Choi SK, Kim YH, Kim SM, et al. Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea. Medicine (Baltimore). 2019;98(21):e15756.
Choi, S. K., Kim, Y. H., Kim, S. M., Wie, J. H., Lee, D. G., Kwon, J. Y., Song, J. H., Lee, S. J., & Park, I. Y. (2019). Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea. Medicine, 98(21), e15756. https://doi.org/10.1097/MD.0000000000015756
Choi SK, et al. Opioid Analgesics Are the Leading Cause of Adverse Drug Reactions in the Obstetric Population in South Korea. Medicine (Baltimore). 2019;98(21):e15756. PubMed PMID: 31124960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea. AU - Choi,Sae Kyung, AU - Kim,Yeon Hee, AU - Kim,Su Mi, AU - Wie,Jung Ha, AU - Lee,Dong-Gun, AU - Kwon,Ji Young, AU - Song,Jeong Hwa, AU - Lee,Su Jeong, AU - Park,In Yang, PY - 2019/5/25/entrez PY - 2019/5/28/pubmed PY - 2019/6/14/medline SP - e15756 EP - e15756 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 21 N2 - Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown.We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications.Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012-December 2015). We analyzed the data of drugs frequently reported to cause ADRs and their clinical features among 3 age groups.A total of 5642 ADRs among 3428 patients were analyzed. The number of ADR reports increased annually. The most common drug categories causing ADRs were analgesics, followed by gynecologic, uterotocolytic, anti-infective, antidiabetic, analgesic, and antihypertensive drugs. Analgesics comprised 6 opioids (morphine, fentanyl, hydromorphone, oxycodone, tramadol, pethidine) and an anti-pyretics (nefopam and ketorolac). As an individual drug, ritodrine (24.4%) was the most frequently reported, followed by morphine, 5-HT3 serotonin antagonist, nefopam, fentanyl, magnesium sulfate, insulin lispro, cefazedone, sodium chloride, hydromorphone, oxycodone, cefotetan, nifedipine, human insulin, tramadol, ketorolac, pethidine, methylergometrine, metoclopramide, and misoprostol (in that order). ADRs most frequently occurred in women aged 25 to 34 years, and the trend of ADR with the 20 most commonly reported medications significantly differed among the age groups (P = .011). In addition, the kind of common causative drugs was different among the age groups.Knowledge of medications and clinical conditions resulting in the highest ADR rates among pregnant women is necessary for medical practitioners to administer proper care. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31124960/Opioid_analgesics_are_the_leading_cause_of_adverse_drug_reactions_in_the_obstetric_population_in_South_Korea L2 - http://dx.doi.org/10.1097/MD.0000000000015756 DB - PRIME DP - Unbound Medicine ER -