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Surgical outcomes in patients with anti-N-methyl D-aspartate receptor encephalitis with ovarian teratoma.
Am J Obstet Gynecol. 2019 11; 221(5):485.e1-485.e10.AJ

Abstract

BACKGROUND

Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune encephalitis mediated by anti-N-methyl-D-aspartate receptor antibodies. Ovarian teratoma is closely related to anti-N-methyl-D-aspartate receptor encephalitis. However, the optimal treatment remains unknown, and strategies used for the diagnosis and therapy, including surgical intervention of ovarian teratoma, are debatable.

OBJECTIVE

The objective of the study was to study the clinical features of anti-N-methyl-D-aspartate receptor encephalitis with ovarian teratoma to further understand the disease.

STUDY DESIGN

This single-center prospective study included patients with anti-NMDAR encephalitis with ovarian teratoma from 2011 to 2016 who were admitted to Peking Union Medical College Hospital, Beijing, and discussed the clinical characteristics, treatment, and prognosis of the disease. The diagnosis of anti-N-methyl-D-aspartate receptor encephalitis was established preoperatively by identifying anti-N-methyl-D-aspartate receptor antibodies in the cerebrospinal fluid. Ovarian teratomas were suspected preoperatively by pelvic ultrasound and were diagnosed pathologically after laparoscopic detection and ovarian tumor resection. All patients were treated with first-line immunotherapy (steroids, intravenous immunoglobulin, and plasmapheresis), and when the therapy failed, they were treated with second-line immunotherapy (cyclophosphamide and rituximab). All patients were followed up regularly, and N-methyl-D-aspartate receptor antibodies, pelvic ultrasound, and neurological condition were monitored. Neurological symptoms were assessed using the modified Rankin Scale.

RESULTS

A total of 108 female patients with anti-N-methyl-D-aspartate receptor encephalitis were screened, of whom, 29 patients (26.9% of 108; mean age ± SD, 23.14 ± 6.59 years) had pathologically confirmed ovarian teratoma. The incidence of fever, decreased consciousness, arrhythmia, central hypoventilation, ventilator-assisted respiration, and intensive unit care (75.9%, 65.5%, 27.6%, 55.2%, 55.2%, and 58.6%, respectively) were significantly higher in patients with ovarian teratoma than in those without ovarian teratoma. The modified Rankin Scale at the acute onset in those 29 patients was 4.11 ± 1.20, which was also much higher than that in patients without ovarian teratoma (3.58 ± 1.08). Of the 29 patients with ovarian teratoma, 22 (75.9%) underwent laparoscopy during the acute onset of neurological symptoms. The mean diameter of the tumor was 4.61 ± 3.41 cm (SD), and the smallest tumor was only 1 cm in the unilateral ovary. All other cysts, except 4 bilateral cysts (13.8%), were unilateral. Only 1 patient was diagnosed pathologically with immature ovarian teratoma, while others had benign ovarian teratomas. In all, 28 patients (96.5%) had a good outcome (modified Rankin Scale ≤2) and 1 died. In the follow-up visit (mean duration, 37.69 months), the relapse rate of encephalitis in patients with ovarian teratoma undergoing laparoscopic cystectomy was 14.6%, whereas for those without ovarian teratoma, the relapse rate was 33.3%. The removal of ovarian teratoma was associated with reduced risk of relapse.

CONCLUSION

Patients having anti-N-methyl-D-aspartate receptor encephalitis with ovarian teratomas tend to present more severe neurological conditions. The diameter of the tumor in these patients is not very large and could be as small as 1 cm, and thus, careful exploration should be considered during surgery. Most of the ovarian teratomas in patients with anti-N-methyl-D-aspartate receptor encephalitis are mature. Early operative treatment is safe and effective because it is associated with reduced risk of relapse and complete recovery.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.Department Neurology, Peking Union Medical College Hospital, Beijing, China.Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.Department Neurology, Peking Union Medical College Hospital, Beijing, China.Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China.Department Neurology, Peking Union Medical College Hospital, Beijing, China. Electronic address: guanhz@263.net.Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Beijing, China. Electronic address: sundw@pumch.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31128109

Citation

Dai, Yi, et al. "Surgical Outcomes in Patients With anti-N-methyl D-aspartate Receptor Encephalitis With Ovarian Teratoma." American Journal of Obstetrics and Gynecology, vol. 221, no. 5, 2019, pp. 485.e1-485.e10.
Dai Y, Zhang J, Ren H, et al. Surgical outcomes in patients with anti-N-methyl D-aspartate receptor encephalitis with ovarian teratoma. Am J Obstet Gynecol. 2019;221(5):485.e1-485.e10.
Dai, Y., Zhang, J., Ren, H., Zhou, X., Chen, J., Cui, L., Lang, J., Guan, H., & Sun, D. (2019). Surgical outcomes in patients with anti-N-methyl D-aspartate receptor encephalitis with ovarian teratoma. American Journal of Obstetrics and Gynecology, 221(5), e1-e10. https://doi.org/10.1016/j.ajog.2019.05.026
Dai Y, et al. Surgical Outcomes in Patients With anti-N-methyl D-aspartate Receptor Encephalitis With Ovarian Teratoma. Am J Obstet Gynecol. 2019;221(5):485.e1-485.e10. PubMed PMID: 31128109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical outcomes in patients with anti-N-methyl D-aspartate receptor encephalitis with ovarian teratoma. AU - Dai,Yi, AU - Zhang,Junji, AU - Ren,Haitao, AU - Zhou,Xingnan, AU - Chen,Juan, AU - Cui,Liying, AU - Lang,Jinghe, AU - Guan,Hongzhi, AU - Sun,Dawei, Y1 - 2019/05/22/ PY - 2019/02/26/received PY - 2019/05/14/revised PY - 2019/05/17/accepted PY - 2019/5/28/pubmed PY - 2020/3/10/medline PY - 2019/5/26/entrez KW - cerebrospinal fluid KW - diagnosis KW - female KW - laparoscopy KW - psychotic disorders KW - tumor resection SP - 485.e1 EP - 485.e10 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 221 IS - 5 N2 - BACKGROUND: Anti-N-methyl-D-aspartate receptor encephalitis is an autoimmune encephalitis mediated by anti-N-methyl-D-aspartate receptor antibodies. Ovarian teratoma is closely related to anti-N-methyl-D-aspartate receptor encephalitis. However, the optimal treatment remains unknown, and strategies used for the diagnosis and therapy, including surgical intervention of ovarian teratoma, are debatable. OBJECTIVE: The objective of the study was to study the clinical features of anti-N-methyl-D-aspartate receptor encephalitis with ovarian teratoma to further understand the disease. STUDY DESIGN: This single-center prospective study included patients with anti-NMDAR encephalitis with ovarian teratoma from 2011 to 2016 who were admitted to Peking Union Medical College Hospital, Beijing, and discussed the clinical characteristics, treatment, and prognosis of the disease. The diagnosis of anti-N-methyl-D-aspartate receptor encephalitis was established preoperatively by identifying anti-N-methyl-D-aspartate receptor antibodies in the cerebrospinal fluid. Ovarian teratomas were suspected preoperatively by pelvic ultrasound and were diagnosed pathologically after laparoscopic detection and ovarian tumor resection. All patients were treated with first-line immunotherapy (steroids, intravenous immunoglobulin, and plasmapheresis), and when the therapy failed, they were treated with second-line immunotherapy (cyclophosphamide and rituximab). All patients were followed up regularly, and N-methyl-D-aspartate receptor antibodies, pelvic ultrasound, and neurological condition were monitored. Neurological symptoms were assessed using the modified Rankin Scale. RESULTS: A total of 108 female patients with anti-N-methyl-D-aspartate receptor encephalitis were screened, of whom, 29 patients (26.9% of 108; mean age ± SD, 23.14 ± 6.59 years) had pathologically confirmed ovarian teratoma. The incidence of fever, decreased consciousness, arrhythmia, central hypoventilation, ventilator-assisted respiration, and intensive unit care (75.9%, 65.5%, 27.6%, 55.2%, 55.2%, and 58.6%, respectively) were significantly higher in patients with ovarian teratoma than in those without ovarian teratoma. The modified Rankin Scale at the acute onset in those 29 patients was 4.11 ± 1.20, which was also much higher than that in patients without ovarian teratoma (3.58 ± 1.08). Of the 29 patients with ovarian teratoma, 22 (75.9%) underwent laparoscopy during the acute onset of neurological symptoms. The mean diameter of the tumor was 4.61 ± 3.41 cm (SD), and the smallest tumor was only 1 cm in the unilateral ovary. All other cysts, except 4 bilateral cysts (13.8%), were unilateral. Only 1 patient was diagnosed pathologically with immature ovarian teratoma, while others had benign ovarian teratomas. In all, 28 patients (96.5%) had a good outcome (modified Rankin Scale ≤2) and 1 died. In the follow-up visit (mean duration, 37.69 months), the relapse rate of encephalitis in patients with ovarian teratoma undergoing laparoscopic cystectomy was 14.6%, whereas for those without ovarian teratoma, the relapse rate was 33.3%. The removal of ovarian teratoma was associated with reduced risk of relapse. CONCLUSION: Patients having anti-N-methyl-D-aspartate receptor encephalitis with ovarian teratomas tend to present more severe neurological conditions. The diameter of the tumor in these patients is not very large and could be as small as 1 cm, and thus, careful exploration should be considered during surgery. Most of the ovarian teratomas in patients with anti-N-methyl-D-aspartate receptor encephalitis are mature. Early operative treatment is safe and effective because it is associated with reduced risk of relapse and complete recovery. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/31128109/Surgical_outcomes_in_patients_with_anti_N_methyl_D_aspartate_receptor_encephalitis_with_ovarian_teratoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(19)30684-2 DB - PRIME DP - Unbound Medicine ER -