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Aberrant expressed long non-coding RNAs in laryngeal squamous-cell carcinoma.
Am J Otolaryngol. 2019 Sep - Oct; 40(5):615-625.AJ

Abstract

PURPOSE

Laryngeal squamous-cell carcinoma (LSCC) is the second most common malignant tumor of head and neck squamous cell carcinoma. The study was aimed to identify key long non-coding RNAs (lncRNAs) biomarkers for LSCC.

METHODS

Differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) between LSCC and adjacent tissues were obtained based on The Cancer Genome Atlas. DElncRNA-DEmRNAs co-expression and DElncRNA-nearby-target DEmRNA interaction networks were constructed. Receiver operating characteristic and survival analysis were performed. A published dataset were as used to validate the result of bioinformatics analysis.

RESULTS

We obtained 1103 DEmRNAs and 306 DElncRNAs between LSCC and adjacent tissues. A total of 338 DElncRNA-DEmRNA co-expression pairs and 229 DElncRNA-nearby-target DEmRNA pairs were obtained. Ten DElncRNAs and six DEmRNAs has great diagnostic value for LSCC. HOXB9 has potential prognostic value for LSCC. The results of GSE84957 validation were generally consistent with our results.

CONCLUSION

Our study provided clues for understanding the mechanism and developing potential biomarkers for LSCC.

Authors+Show Affiliations

Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Obstetrics, Maternal and Child Health Hospital of RenCheng District, Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China.Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital of Jining, Jining, Shandong, China. Electronic address: zhangmei_doctor@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31128861

Citation

Li, Hu, et al. "Aberrant Expressed Long Non-coding RNAs in Laryngeal Squamous-cell Carcinoma." American Journal of Otolaryngology, vol. 40, no. 5, 2019, pp. 615-625.
Li H, Wang FL, Li W, et al. Aberrant expressed long non-coding RNAs in laryngeal squamous-cell carcinoma. Am J Otolaryngol. 2019;40(5):615-625.
Li, H., Wang, F. L., Li, W., Fei, Y. H., Wang, Y. T., Zhang, J. E., Bi, H. Y., & Zhang, M. (2019). Aberrant expressed long non-coding RNAs in laryngeal squamous-cell carcinoma. American Journal of Otolaryngology, 40(5), 615-625. https://doi.org/10.1016/j.amjoto.2019.05.002
Li H, et al. Aberrant Expressed Long Non-coding RNAs in Laryngeal Squamous-cell Carcinoma. Am J Otolaryngol. 2019 Sep - Oct;40(5):615-625. PubMed PMID: 31128861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aberrant expressed long non-coding RNAs in laryngeal squamous-cell carcinoma. AU - Li,Hu, AU - Wang,Fu-Ling, AU - Li,Wei, AU - Fei,Yong-Hua, AU - Wang,Ya-Ting, AU - Zhang,Jing-E, AU - Bi,Hui-Yun, AU - Zhang,Mei, Y1 - 2019/05/09/ PY - 2019/01/23/received PY - 2019/05/08/accepted PY - 2019/5/28/pubmed PY - 2020/2/14/medline PY - 2019/5/27/entrez KW - Laryngeal squamous cell carcinoma (LSCC) KW - Long non-coding RNAs (lncRNAs) KW - The Cancer Genome Atlas (TCGA) KW - mRNA SP - 615 EP - 625 JF - American journal of otolaryngology JO - Am J Otolaryngol VL - 40 IS - 5 N2 - PURPOSE: Laryngeal squamous-cell carcinoma (LSCC) is the second most common malignant tumor of head and neck squamous cell carcinoma. The study was aimed to identify key long non-coding RNAs (lncRNAs) biomarkers for LSCC. METHODS: Differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) between LSCC and adjacent tissues were obtained based on The Cancer Genome Atlas. DElncRNA-DEmRNAs co-expression and DElncRNA-nearby-target DEmRNA interaction networks were constructed. Receiver operating characteristic and survival analysis were performed. A published dataset were as used to validate the result of bioinformatics analysis. RESULTS: We obtained 1103 DEmRNAs and 306 DElncRNAs between LSCC and adjacent tissues. A total of 338 DElncRNA-DEmRNA co-expression pairs and 229 DElncRNA-nearby-target DEmRNA pairs were obtained. Ten DElncRNAs and six DEmRNAs has great diagnostic value for LSCC. HOXB9 has potential prognostic value for LSCC. The results of GSE84957 validation were generally consistent with our results. CONCLUSION: Our study provided clues for understanding the mechanism and developing potential biomarkers for LSCC. SN - 1532-818X UR - https://www.unboundmedicine.com/medline/citation/31128861/Aberrant_expressed_long_non_coding_RNAs_in_laryngeal_squamous_cell_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-0709(19)30050-X DB - PRIME DP - Unbound Medicine ER -