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Ionic liquid as antibacterial agent for an experimental orthodontic adhesive.
Dent Mater 2019; 35(8):1155-1165DM

Abstract

OBJECTIVE

The aim of this study was to formulate and evaluate experimental orthodontic adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2).

METHODS

The experimental orthodontic adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity.

RESULTS

BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p < 0.05). G5% and GCtrl had no differences for softening in solvent (p > 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p < 0.05) without cytotoxicity (p > 0.05).

SIGNIFICANCE

To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental orthodontic adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental orthodontic resin.

Authors+Show Affiliations

Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: isadora.garcia@hotmail.com.Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: carolinajungferreira@yahoo.com.br.Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Ave, 9500, Agronomia, Porto Alegre, RS, 91501970, Brazil. Electronic address: vivi_qui@hotmail.com.Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: vicente.leitune@ufrgs.br.Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: susana.samuel@ufrgs.br.Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: gabriela.balbinot@ufrgs.br.Department of Microbiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Sarmento Leite Street, 500, Farroupilha, 90035-190, Brazil. Electronic address: amanda.motta@ufrgs.br.Laboratory of Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: fernanda.visioli@ufrgs.br.Laboratory of Molecular Catalysis, Institute of Chemistry, Federal University of Rio Grande do Sul, Bento Gonçalves Ave, 9500, Agronomia, Porto Alegre, RS, 91501970, Brazil. Electronic address: jackson.scholten@ufrgs.br.Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, Porto Alegre, RS, 90035-003, Brazil. Electronic address: fabricio.collares@ufrgs.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31128938

Citation

Martini Garcia, Isadora, et al. "Ionic Liquid as Antibacterial Agent for an Experimental Orthodontic Adhesive." Dental Materials : Official Publication of the Academy of Dental Materials, vol. 35, no. 8, 2019, pp. 1155-1165.
Martini Garcia I, Jung Ferreira C, de Souza VS, et al. Ionic liquid as antibacterial agent for an experimental orthodontic adhesive. Dent Mater. 2019;35(8):1155-1165.
Martini Garcia, I., Jung Ferreira, C., de Souza, V. S., Castelo Branco Leitune, V., Samuel, S. M. W., de Souza Balbinot, G., ... Mezzomo Collares, F. (2019). Ionic liquid as antibacterial agent for an experimental orthodontic adhesive. Dental Materials : Official Publication of the Academy of Dental Materials, 35(8), pp. 1155-1165. doi:10.1016/j.dental.2019.05.010.
Martini Garcia I, et al. Ionic Liquid as Antibacterial Agent for an Experimental Orthodontic Adhesive. Dent Mater. 2019;35(8):1155-1165. PubMed PMID: 31128938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ionic liquid as antibacterial agent for an experimental orthodontic adhesive. AU - Martini Garcia,Isadora, AU - Jung Ferreira,Carolina, AU - de Souza,Virgínia Serra, AU - Castelo Branco Leitune,Vicente, AU - Samuel,Susana Maria Werner, AU - de Souza Balbinot,Gabriela, AU - de Souza da Motta,Amanda, AU - Visioli,Fernanda, AU - Damiani Scholten,Jackson, AU - Mezzomo Collares,Fabrício, Y1 - 2019/05/23/ PY - 2018/10/18/received PY - 2019/04/08/revised PY - 2019/05/07/accepted PY - 2019/5/28/pubmed PY - 2019/5/28/medline PY - 2019/5/27/entrez KW - Antibacterial capability KW - Biocompatibility KW - Dental caries KW - Orthodontics KW - Tooth demineralization SP - 1155 EP - 1165 JF - Dental materials : official publication of the Academy of Dental Materials JO - Dent Mater VL - 35 IS - 8 N2 - OBJECTIVE: The aim of this study was to formulate and evaluate experimental orthodontic adhesives with different concentrations of 1-n-butyl-3-methylimidazoilium bis(trifluoromethanesulfonyl)imide (BMIM.NTf2). METHODS: The experimental orthodontic adhesives were formulated with methacrylate monomers, photoinitiators and silica colloidal. The ionic liquid BMIM.NTf2 was synthesized and characterized. BMIM.NTf2 was added at 5 (G5%), 10 (G10%) and 15 (G15%) wt.%. One group contained no BMIM.NTf2 to function as control (GCtrl). The adhesives were evaluated for polymerization kinetics, degree of conversion (DC), Knoop hardness and softening in solvent, ultimate tensile strength (UTS), shear bond strength (SBS), thermogravimetric analysis (TGA), antibacterial activity and cytotoxicity. RESULTS: BMI.NTf2 showed the characteristic chemical peaks. The polymerization kinetics were different among the groups. G10% and G15% showed higher DC (p < 0.05). G5% and GCtrl had no differences for softening in solvent (p > 0.05). There were no differences for UTS (p > 0.05) and SBS (p > 0.05). TGA showed one different peak for G15%. All groups with BMIM.NTf2 showed antibacterial activity compared to GCtrl (p < 0.05) without cytotoxicity (p > 0.05). SIGNIFICANCE: To reduce biofilm formation around brackets and to prevent demineralization at susceptible sites, materials have been developed with antibacterial properties. In this study, a new experimental orthodontic adhesive was formulated with an imidazolium ionic liquid (BMIM.NTf2) as antibacterial agent. The incorporation of 5 wt.% of ionic liquid decreased biofilm formation without affecting the physico-chemical properties and cytotoxicity of an experimental orthodontic resin. SN - 1879-0097 UR - https://www.unboundmedicine.com/medline/citation/31128938/Ionic_liquid_as_antibacterial_agent_for_an_experimental_orthodontic_adhesive L2 - https://linkinghub.elsevier.com/retrieve/pii/S0109-5641(18)31262-4 DB - PRIME DP - Unbound Medicine ER -