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The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos.
New Bioeth. 2019 Jun; 25(2):137-152.NB

Abstract

With recent reports that a Chinese scientist used CRISPR-Cas9 to heritably edit the genomes of human embryos (i.e., germline editing) brought to term, discussions regarding the ethics of the technology are urgently needed. Although certain applications of germline editing have been endorsed by both the National Academy of Sciences (US) and the Nuffield Council (UK), this paper explores the ethical concerns related even to such therapeutic uses of the technology. Additionally, this paper questions whether the technology could ever feasibly be contained to the therapeutic realm. Consequently, this paper necessarily considers the ethical concerns related to enhancement uses of the technology even if only therapeutic applications are initially considered. In light of the concomitant risks, this paper assesses the technology's countervailing benefits to conclude they do not prevail given that similar outcomes can largely be achieved with existing technologies. Consequently, this paper recommends an international ban on germline editing.

Authors+Show Affiliations

a Bioethics Department of the School of Professional Studies , Columbia University , New York , USA. b Institute of Bioethics, Bellarmine College of Arts and Sciences , Loyola Marymount University , Los Angeles , California , USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31130112

Citation

Gumer, Jennifer M.. "The Wisdom of Germline Editing: an Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos." The New Bioethics : a Multidisciplinary Journal of Biotechnology and the Body, vol. 25, no. 2, 2019, pp. 137-152.
Gumer JM. The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos. New Bioeth. 2019;25(2):137-152.
Gumer, J. M. (2019). The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos. The New Bioethics : a Multidisciplinary Journal of Biotechnology and the Body, 25(2), 137-152. https://doi.org/10.1080/20502877.2019.1606151
Gumer JM. The Wisdom of Germline Editing: an Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos. New Bioeth. 2019;25(2):137-152. PubMed PMID: 31130112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Wisdom of Germline Editing: An Ethical Analysis of the Use of CRISPR-Cas9 to Edit Human Embryos. A1 - Gumer,Jennifer M, PY - 2019/5/28/entrez PY - 2019/5/28/pubmed PY - 2019/10/28/medline KW - CRISPR-Cas9 KW - designer babies KW - eugenics KW - genetics KW - germline editing SP - 137 EP - 152 JF - The New bioethics : a multidisciplinary journal of biotechnology and the body JO - New Bioeth VL - 25 IS - 2 N2 - With recent reports that a Chinese scientist used CRISPR-Cas9 to heritably edit the genomes of human embryos (i.e., germline editing) brought to term, discussions regarding the ethics of the technology are urgently needed. Although certain applications of germline editing have been endorsed by both the National Academy of Sciences (US) and the Nuffield Council (UK), this paper explores the ethical concerns related even to such therapeutic uses of the technology. Additionally, this paper questions whether the technology could ever feasibly be contained to the therapeutic realm. Consequently, this paper necessarily considers the ethical concerns related to enhancement uses of the technology even if only therapeutic applications are initially considered. In light of the concomitant risks, this paper assesses the technology's countervailing benefits to conclude they do not prevail given that similar outcomes can largely be achieved with existing technologies. Consequently, this paper recommends an international ban on germline editing. SN - 2050-2885 UR - https://www.unboundmedicine.com/medline/citation/31130112/The_Wisdom_of_Germline_Editing:_An_Ethical_Analysis_of_the_Use_of_CRISPR_Cas9_to_Edit_Human_Embryos_ DB - PRIME DP - Unbound Medicine ER -
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