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Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress-induced MAPK and NF-kB pathway in Sprague Dawley rats.
Hum Exp Toxicol. 2019 Sep; 38(9):1082-1091.HE

Abstract

Oxidative stress (OS) is one of the responsible factors for causing renal diseases. For the treatment or prevention of the renal disease, antioxidants use could be a hopeful therapeutic mediation as they block the oxidative reaction along with inflammatory process. Wogonin (Wog) is a plant flavonoid, a pharmacologically active component of Scutellaria baicalensis Georgi (Huang Qui), which exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Wog on cadmium (Cd)-induced nephron toxicity in rats. Administering (10 and 20 mg/kg) intraperitoneally diminished Cd-induced anomalies in kidney histology and creatinine and serum urea levels. Wog therapy reduced the Cd-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. Western blot analysis demonstrated that Wog abolished proinflammatory nuclear factor-kappa B (NF-κB) p65 stimulation, phosphorylation of p38 mitogen-activated protein kinases (MAPKs). In all, Wog demonstrated antioxidative and anti-inflammatory effects in Cd- intoxicated rats by obstructing OS and activation of NF-κB via restricting the stimulation of upstream kinases inclusive of MAPKs.

Authors+Show Affiliations

1 Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.2 Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.2 Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.3 Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31132876

Citation

Jiao, D, et al. "Nephroprotective Effect of Wogonin Against Cadmium-induced Nephrotoxicity Via Inhibition of Oxidative Stress-induced MAPK and NF-kB Pathway in Sprague Dawley Rats." Human & Experimental Toxicology, vol. 38, no. 9, 2019, pp. 1082-1091.
Jiao D, Jiang Q, Liu Y, et al. Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress-induced MAPK and NF-kB pathway in Sprague Dawley rats. Hum Exp Toxicol. 2019;38(9):1082-1091.
Jiao, D., Jiang, Q., Liu, Y., & Ji, L. (2019). Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress-induced MAPK and NF-kB pathway in Sprague Dawley rats. Human & Experimental Toxicology, 38(9), 1082-1091. https://doi.org/10.1177/0960327119842635
Jiao D, et al. Nephroprotective Effect of Wogonin Against Cadmium-induced Nephrotoxicity Via Inhibition of Oxidative Stress-induced MAPK and NF-kB Pathway in Sprague Dawley Rats. Hum Exp Toxicol. 2019;38(9):1082-1091. PubMed PMID: 31132876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress-induced MAPK and NF-kB pathway in Sprague Dawley rats. AU - Jiao,D, AU - Jiang,Q, AU - Liu,Y, AU - Ji,L, Y1 - 2019/05/28/ PY - 2019/5/28/pubmed PY - 2020/1/18/medline PY - 2019/5/29/entrez KW - Antioxidant KW - apoptosis KW - cadmium KW - nephroptotection KW - nephrotoxicity KW - wogonin SP - 1082 EP - 1091 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 38 IS - 9 N2 - Oxidative stress (OS) is one of the responsible factors for causing renal diseases. For the treatment or prevention of the renal disease, antioxidants use could be a hopeful therapeutic mediation as they block the oxidative reaction along with inflammatory process. Wogonin (Wog) is a plant flavonoid, a pharmacologically active component of Scutellaria baicalensis Georgi (Huang Qui), which exhibits antioxidant activity. In this investigation, we explored the nephroprotective activity of Wog on cadmium (Cd)-induced nephron toxicity in rats. Administering (10 and 20 mg/kg) intraperitoneally diminished Cd-induced anomalies in kidney histology and creatinine and serum urea levels. Wog therapy reduced the Cd-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. Western blot analysis demonstrated that Wog abolished proinflammatory nuclear factor-kappa B (NF-κB) p65 stimulation, phosphorylation of p38 mitogen-activated protein kinases (MAPKs). In all, Wog demonstrated antioxidative and anti-inflammatory effects in Cd- intoxicated rats by obstructing OS and activation of NF-κB via restricting the stimulation of upstream kinases inclusive of MAPKs. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/31132876/Nephroprotective_effect_of_wogonin_against_cadmium_induced_nephrotoxicity_via_inhibition_of_oxidative_stress_induced_MAPK_and_NF_kB_pathway_in_Sprague_Dawley_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0960327119842635?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -