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A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia.
J Anal Toxicol. 2019 Aug 23; 43(7):528-535.JA

Abstract

A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. The ATS-related drugs analyzed in this study include ephedrine, pseudoephedrine, amphetamine, methamphetamine, MDMA (3,4-Methylenedioxymethamphetamine), MDA (3,4-Methylenedioxyamphetamine), MDEA (3,4-Methylenedioxy-N-ethylamphetamine) and phentermine. The relative standard deviation for inter and intraday was less than 15% while recoveries ranged from 80% to 120% for all three matrices, i.e., whole blood, urine and dried blood stain. All compounds gave library matching percentage of more than 85% based on the purity. This method was proven to be simple and robust, and provide high confident results complemented with library matching confirmation.

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Authors+Show Affiliations

Zubaidi FA
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. Department of Chemistry Malaysia, Ministry of Science, Technology and Innovation (MOSTI), Petaling Jaya, Malaysia.
Choo YM
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Tan GH
Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Hamid HA
Department of Chemistry Malaysia, Ministry of Science, Technology and Innovation (MOSTI), Petaling Jaya, Malaysia.
Choy YK
Department of Chemistry Malaysia, Ministry of Science, Technology and Innovation (MOSTI), Petaling Jaya, Malaysia.

MeSH

AmphetamineBlood StainsCentral Nervous System StimulantsChromatography, LiquidForensic ToxicologyHumansLimit of DetectionReproducibility of ResultsSubstance Abuse DetectionTandem Mass Spectrometry

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31141150

Citation

Zubaidi, Fathiah A., et al. "A Novel Liquid Chromatography Tandem Mass Spectrometry Technique Using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 With Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia." Journal of Analytical Toxicology, vol. 43, no. 7, 2019, pp. 528-535.
Zubaidi FA, Choo YM, Tan GH, et al. A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia. J Anal Toxicol. 2019;43(7):528-535.
Zubaidi, F. A., Choo, Y. M., Tan, G. H., Hamid, H. A., & Choy, Y. K. (2019). A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia. Journal of Analytical Toxicology, 43(7), 528-535. https://doi.org/10.1093/jat/bkz017
Zubaidi FA, et al. A Novel Liquid Chromatography Tandem Mass Spectrometry Technique Using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 With Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia. J Anal Toxicol. 2019 Aug 23;43(7):528-535. PubMed PMID: 31141150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood Stain (DBS)-Application to Forensic Toxicology Cases in Malaysia. AU - Zubaidi,Fathiah A, AU - Choo,Yeun-Mun, AU - Tan,Guan-Huat, AU - Hamid,Hamimah Abd, AU - Choy,Yap Ken, PY - 2018/07/30/received PY - 2018/11/21/revised PY - 2019/02/27/accepted PY - 2019/5/30/pubmed PY - 2020/2/6/medline PY - 2019/5/30/entrez KW - ATS-related drugs KW - LC-MS/MS KW - MRM-EPI-MRM3 KW - dried blood stain sample KW - urine sample KW - whole blood sample SP - 528 EP - 535 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 43 IS - 7 N2 - A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. The ATS-related drugs analyzed in this study include ephedrine, pseudoephedrine, amphetamine, methamphetamine, MDMA (3,4-Methylenedioxymethamphetamine), MDA (3,4-Methylenedioxyamphetamine), MDEA (3,4-Methylenedioxy-N-ethylamphetamine) and phentermine. The relative standard deviation for inter and intraday was less than 15% while recoveries ranged from 80% to 120% for all three matrices, i.e., whole blood, urine and dried blood stain. All compounds gave library matching percentage of more than 85% based on the purity. This method was proven to be simple and robust, and provide high confident results complemented with library matching confirmation. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/31141150/A_Novel_Liquid_Chromatography_Tandem_Mass_Spectrometry_Technique_using_Multi_Period_Multi_Experiment_of_MRM_EPI_MRM3_with_Library_Matching_for_Simultaneous_Determination_of_Amphetamine_Type_Stimulants_Related_Drugs_in_Whole_Blood_Urine_and_Dried_Blood_Stain__DBS__Application_to_Forensic_Toxicology_Cases_in_Malaysia_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkz017 DB - PRIME DP - Unbound Medicine ER -