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Prednisolone-induced virginal mammary hypertrophy: Case report.
Int J Surg Case Rep 2019; 59:140-143IJ

Abstract

INTRODUCTION

Virginal mammary hypertrophy (VMH) is a rare benign disorder of the breast characterized by excessive enlargement of one or both breasts. It usually presents during adolescence. Drug-induced VMH has been scarcely reported in case reports. Review of the literature showed that prednisolone-induced gigantomastia was reported in a single study on a 47-year-old female. In this study, a case of VMH in a 17-year-old girl following prednisolone treatment will be described. Clinical presentation, clinical findings, diagnostic work-up, management and follow up are discussed.

PRESENTATION OF CASE

A 17-year-old, single female presented to the plastic surgery department at our institute with progressive enlargement of both breasts, 2 months following treatment with prednisolone. Incisional biopsy excluded other breast differential diagnoses. The patient was managed surgically with bilateral mammaplasty with free nipple-areola graft. A total of 8.325 kg of breast tissue was resected. Follow-up 48 months postoperatively revealed good patient satisfaction with no recurrence of breast hypertrophy.

DISCUSSION

Although the estrogen theory is regarded as the most credible explanation for VMH, several cases of drug-induced mammary hypertrophy have been reported. This study may be the first reported case of adolescent prednisolone-induced VMH. Mammaplasty is an accepted treatment despite its possible association with a higher recurrence rate.

CONCLUSION

VMH may be a rare complication of prednisolone treatment. It should be considered in patients presenting with breast hypertrophy following steroid administration.

Authors+Show Affiliations

Department of Plastic and Reconstructive surgery, Jordan University Hospital, Amman, Jordan. Electronic address: sjabaiti@yahoo.co.uk.Department of Pathology, Jordan University Hospital, Amman, Jordan; Department of Pathology, King Hussein Medical Center, Amman, Jordan. Electronic address: l_fayyad@yahoo.com.Faculty of Medicine, University of Jordan, Amman, Jordan. Electronic address: ulaisleem289@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31146195

Citation

Jabaiti, Samir, et al. "Prednisolone-induced Virginal Mammary Hypertrophy: Case Report." International Journal of Surgery Case Reports, vol. 59, 2019, pp. 140-143.
Jabaiti S, Fayyad L, Isleem U. Prednisolone-induced virginal mammary hypertrophy: Case report. Int J Surg Case Rep. 2019;59:140-143.
Jabaiti, S., Fayyad, L., & Isleem, U. (2019). Prednisolone-induced virginal mammary hypertrophy: Case report. International Journal of Surgery Case Reports, 59, pp. 140-143. doi:10.1016/j.ijscr.2019.04.042.
Jabaiti S, Fayyad L, Isleem U. Prednisolone-induced Virginal Mammary Hypertrophy: Case Report. Int J Surg Case Rep. 2019;59:140-143. PubMed PMID: 31146195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prednisolone-induced virginal mammary hypertrophy: Case report. AU - Jabaiti,Samir, AU - Fayyad,Luma, AU - Isleem,Ula, Y1 - 2019/05/16/ PY - 2019/01/30/received PY - 2019/03/22/revised PY - 2019/04/16/accepted PY - 2019/5/31/pubmed PY - 2019/5/31/medline PY - 2019/5/31/entrez KW - Case report KW - Mammaplasty KW - Prednisolone KW - Virginal mammary hypertrophy SP - 140 EP - 143 JF - International journal of surgery case reports JO - Int J Surg Case Rep VL - 59 N2 - INTRODUCTION: Virginal mammary hypertrophy (VMH) is a rare benign disorder of the breast characterized by excessive enlargement of one or both breasts. It usually presents during adolescence. Drug-induced VMH has been scarcely reported in case reports. Review of the literature showed that prednisolone-induced gigantomastia was reported in a single study on a 47-year-old female. In this study, a case of VMH in a 17-year-old girl following prednisolone treatment will be described. Clinical presentation, clinical findings, diagnostic work-up, management and follow up are discussed. PRESENTATION OF CASE: A 17-year-old, single female presented to the plastic surgery department at our institute with progressive enlargement of both breasts, 2 months following treatment with prednisolone. Incisional biopsy excluded other breast differential diagnoses. The patient was managed surgically with bilateral mammaplasty with free nipple-areola graft. A total of 8.325 kg of breast tissue was resected. Follow-up 48 months postoperatively revealed good patient satisfaction with no recurrence of breast hypertrophy. DISCUSSION: Although the estrogen theory is regarded as the most credible explanation for VMH, several cases of drug-induced mammary hypertrophy have been reported. This study may be the first reported case of adolescent prednisolone-induced VMH. Mammaplasty is an accepted treatment despite its possible association with a higher recurrence rate. CONCLUSION: VMH may be a rare complication of prednisolone treatment. It should be considered in patients presenting with breast hypertrophy following steroid administration. SN - 2210-2612 UR - https://www.unboundmedicine.com/medline/citation/31146195/Prednisolone-induced_virginal_mammary_hypertrophy:_Case_report L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-2612(19)30235-4 DB - PRIME DP - Unbound Medicine ER -