Tags

Type your tag names separated by a space and hit enter

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes.
Nature. 1987 Sep 10-16; 329(6135):157-9.Nat

Abstract

The growth of mature T lymphocytes after activation by antigen is regulated by the binding and endocytosis of interleukin-2 (IL-2). In the thymus, approximately 50% of adult thymocytes that carry neither the CD4 nor the CD8 antigen and day 14-15 fetal CD4-8- thymocytes express receptors for IL-2(IL-2R). The CD4-8- (double-negative) subpopulation of thymocytes contains the precursors of cells that can differentiate along an unknown pathway into thymocytes bearing either CD8 or CD4, with the characteristics of mature T lymphocytes. The basis for IL-2R expression by double-negative thymocytes is unclear as they appear to lack a functional T-cell receptor/CD3 complex through which activation of peripheral T cells is mediated. The argument for a role for IL-2 in thymocyte differentiation has also been complicated by conflicting reports on the inability or capability of double-negative thymocytes to respond to IL-2 in vitro. At present, both the nature of the stimuli within the thymic micro-environment which induce IL-2R expression and its relevance to thymocyte differentiation are not known. We show here that the IL-2R-bearing subset has a greater potential to differentiate into phenotypically mature T lymphocytes than do IL-2R-negative thymocytes. In addition, progeny of IL-2R-negative donor cells transiently express IL-2R in the thymuses of adoptive hosts before generating CD8 and/or CD4-positive thymocytes. These results identify the IL-2R-positive cells as a more differentiated double-negative thymocyte subset on the pathway to mature T lymphocytes.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3114641

Citation

Shimonkevitz, R P., et al. "Transient Expression of IL-2 Receptor Precedes the Differentiation of Immature Thymocytes." Nature, vol. 329, no. 6135, 1987, pp. 157-9.
Shimonkevitz RP, Husmann LA, Bevan MJ, et al. Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. Nature. 1987;329(6135):157-9.
Shimonkevitz, R. P., Husmann, L. A., Bevan, M. J., & Crispe, I. N. (1987). Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. Nature, 329(6135), 157-9.
Shimonkevitz RP, et al. Transient Expression of IL-2 Receptor Precedes the Differentiation of Immature Thymocytes. Nature. 1987 Sep 10-16;329(6135):157-9. PubMed PMID: 3114641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes. AU - Shimonkevitz,R P, AU - Husmann,L A, AU - Bevan,M J, AU - Crispe,I N, PY - 1987/9/10/pubmed PY - 1987/9/10/medline PY - 1987/9/10/entrez SP - 157 EP - 9 JF - Nature JO - Nature VL - 329 IS - 6135 N2 - The growth of mature T lymphocytes after activation by antigen is regulated by the binding and endocytosis of interleukin-2 (IL-2). In the thymus, approximately 50% of adult thymocytes that carry neither the CD4 nor the CD8 antigen and day 14-15 fetal CD4-8- thymocytes express receptors for IL-2(IL-2R). The CD4-8- (double-negative) subpopulation of thymocytes contains the precursors of cells that can differentiate along an unknown pathway into thymocytes bearing either CD8 or CD4, with the characteristics of mature T lymphocytes. The basis for IL-2R expression by double-negative thymocytes is unclear as they appear to lack a functional T-cell receptor/CD3 complex through which activation of peripheral T cells is mediated. The argument for a role for IL-2 in thymocyte differentiation has also been complicated by conflicting reports on the inability or capability of double-negative thymocytes to respond to IL-2 in vitro. At present, both the nature of the stimuli within the thymic micro-environment which induce IL-2R expression and its relevance to thymocyte differentiation are not known. We show here that the IL-2R-bearing subset has a greater potential to differentiate into phenotypically mature T lymphocytes than do IL-2R-negative thymocytes. In addition, progeny of IL-2R-negative donor cells transiently express IL-2R in the thymuses of adoptive hosts before generating CD8 and/or CD4-positive thymocytes. These results identify the IL-2R-positive cells as a more differentiated double-negative thymocyte subset on the pathway to mature T lymphocytes. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/3114641/Transient_expression_of_IL_2_receptor_precedes_the_differentiation_of_immature_thymocytes_ L2 - https://doi.org/10.1038/329157a0 DB - PRIME DP - Unbound Medicine ER -