Tags

Type your tag names separated by a space and hit enter

Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using magnetic resonance imaging: a study protocol for a randomized controlled trial.
Trials. 2019 May 30; 20(1):310.T

Abstract

BACKGROUND

Mild cognitive impairment (MCI) is defined as a decline in cognitive state with preservation of activities of daily living. Medications such as donepezil and rivastigmine have been commonly prescribed for MCI, but their use is controversial. Acupuncture has been widely used in Korea and has been shown to improve cognitive function. The aim of this study is to evaluate the efficacy of acupuncture for MCI and investigate the effect of acupuncture on structural and functional brain changes in patients with MCI.

METHODS

This study is a randomized, assessor-blinded, sham-controlled trial. Fifty participants with MCI will be randomly assigned to the acupuncture group (n = 25) or sham acupuncture group (n = 25). The acupuncture group will receive acupuncture treatment at nine acupuncture points (GV20, EX-HN1, bilateral LI4, and ST36) twice a week for 12 weeks. The sham acupuncture group will receive sham acupuncture treatment at the same points with non-penetrating sham needles. Both groups will be restricted from all other treatments for the improvement of cognitive function. The primary outcome measure is the Digit Span Test (DST). The secondary outcome measures are the Digit Symbol Substitution Test (DSST), Korean version of Montreal Cognitive Assessment (MoCA-K), Seoul Neuropsychological Screening Battery-II (SNSB-II), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI), working memory (WM) task performance score, and structural/functional brain changes. Outcomes will be assessed at screening, baseline, 4 and 8 weeks, and after the end of treatment. We will also observe adverse events. In the statistical analysis, a full analysis set and per-protocol analysis will be performed.

DISCUSSION

This randomized clinical trial aims to examine the efficacy of acupuncture treatment for MCI. Neuropsychological tests, psychological inventories for measuring depression and anxiety, and magnetic resonance imaging will be performed to investigate the underlying neurological mechanisms and the association between cognition, emotion, and brain networks following acupuncture treatment. The results of the trial will provide evidence supporting the efficacy of acupuncture and also add to the neurobiological understanding of acupuncture treatment for MCI.

TRIAL REGISTRATION

Clinical Research Information Service, KCT0002896 . Registered on 25 May 2018.

Authors+Show Affiliations

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea.Department of Neuropsychiatry, Kyung Hee University Medical Center Korean Medicine Hospital, Seoul, 02447, Republic of Korea.Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul, 05278, Republic of Korea.Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea.Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. Department of Neuropsychiatry, Kyung Hee University Medical Center Korean Medicine Hospital, Seoul, 02447, Republic of Korea.Department of Radiology, Kyung Hee University Hospital, Seoul, 02447, Republic of Korea. Department of Radiology, Kyung Hee University College of Medicine, Seoul, 02447, Republic of Korea.Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul, 02447, Republic of Korea. lovepwr@khu.ac.kr. Department of Neuropsychiatry, Kyung Hee University Korean Medicine Hospital at Gangdong, Seoul, 05278, Republic of Korea. lovepwr@khu.ac.kr.Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea. omdjun@kiom.re.kr. Korean Medicine Life Science, University of Science & Technology (UST), Campus of Korea Institute of Oriental Medicine, Daejeon, 34054, Republic of Korea. omdjun@kiom.re.kr.

Pub Type(s)

Clinical Trial Protocol
Journal Article

Language

eng

PubMed ID

31146774

Citation

Suh, Hyo-Weon, et al. "Neurocircuitry of Acupuncture Effect On Cognitive Improvement in Patients With Mild Cognitive Impairment Using Magnetic Resonance Imaging: a Study Protocol for a Randomized Controlled Trial." Trials, vol. 20, no. 1, 2019, p. 310.
Suh HW, Kim J, Kwon O, et al. Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using magnetic resonance imaging: a study protocol for a randomized controlled trial. Trials. 2019;20(1):310.
Suh, H. W., Kim, J., Kwon, O., Cho, S. H., Kim, J. W., Kwak, H. Y., Kim, Y., Lee, K. M., Chung, S. Y., & Lee, J. H. (2019). Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using magnetic resonance imaging: a study protocol for a randomized controlled trial. Trials, 20(1), 310. https://doi.org/10.1186/s13063-019-3446-9
Suh HW, et al. Neurocircuitry of Acupuncture Effect On Cognitive Improvement in Patients With Mild Cognitive Impairment Using Magnetic Resonance Imaging: a Study Protocol for a Randomized Controlled Trial. Trials. 2019 May 30;20(1):310. PubMed PMID: 31146774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurocircuitry of acupuncture effect on cognitive improvement in patients with mild cognitive impairment using magnetic resonance imaging: a study protocol for a randomized controlled trial. AU - Suh,Hyo-Weon, AU - Kim,Jieun, AU - Kwon,Ojin, AU - Cho,Seung-Hun, AU - Kim,Jong Woo, AU - Kwak,Hui-Yong, AU - Kim,Yunna, AU - Lee,Kyung Mi, AU - Chung,Sun-Yong, AU - Lee,Jun-Hwan, Y1 - 2019/05/30/ PY - 2018/11/28/received PY - 2019/05/13/accepted PY - 2019/6/1/entrez PY - 2019/5/31/pubmed PY - 2019/12/24/medline KW - Acupuncture KW - Cognitive function KW - MCI KW - Mild cognitive impairment KW - Neuroimaging SP - 310 EP - 310 JF - Trials JO - Trials VL - 20 IS - 1 N2 - BACKGROUND: Mild cognitive impairment (MCI) is defined as a decline in cognitive state with preservation of activities of daily living. Medications such as donepezil and rivastigmine have been commonly prescribed for MCI, but their use is controversial. Acupuncture has been widely used in Korea and has been shown to improve cognitive function. The aim of this study is to evaluate the efficacy of acupuncture for MCI and investigate the effect of acupuncture on structural and functional brain changes in patients with MCI. METHODS: This study is a randomized, assessor-blinded, sham-controlled trial. Fifty participants with MCI will be randomly assigned to the acupuncture group (n = 25) or sham acupuncture group (n = 25). The acupuncture group will receive acupuncture treatment at nine acupuncture points (GV20, EX-HN1, bilateral LI4, and ST36) twice a week for 12 weeks. The sham acupuncture group will receive sham acupuncture treatment at the same points with non-penetrating sham needles. Both groups will be restricted from all other treatments for the improvement of cognitive function. The primary outcome measure is the Digit Span Test (DST). The secondary outcome measures are the Digit Symbol Substitution Test (DSST), Korean version of Montreal Cognitive Assessment (MoCA-K), Seoul Neuropsychological Screening Battery-II (SNSB-II), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI), working memory (WM) task performance score, and structural/functional brain changes. Outcomes will be assessed at screening, baseline, 4 and 8 weeks, and after the end of treatment. We will also observe adverse events. In the statistical analysis, a full analysis set and per-protocol analysis will be performed. DISCUSSION: This randomized clinical trial aims to examine the efficacy of acupuncture treatment for MCI. Neuropsychological tests, psychological inventories for measuring depression and anxiety, and magnetic resonance imaging will be performed to investigate the underlying neurological mechanisms and the association between cognition, emotion, and brain networks following acupuncture treatment. The results of the trial will provide evidence supporting the efficacy of acupuncture and also add to the neurobiological understanding of acupuncture treatment for MCI. TRIAL REGISTRATION: Clinical Research Information Service, KCT0002896 . Registered on 25 May 2018. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/31146774/Neurocircuitry_of_acupuncture_effect_on_cognitive_improvement_in_patients_with_mild_cognitive_impairment_using_magnetic_resonance_imaging:_a_study_protocol_for_a_randomized_controlled_trial_ L2 - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3446-9 DB - PRIME DP - Unbound Medicine ER -