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Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients with Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia.
Adv Ther. 2019 08; 36(8):2072-2085.AT

Abstract

INTRODUCTION

This study examined the dynamics of 24-h electrocardiogram (ECG) monitoring parameters (Holter monitoring) in patients with ischemic heart disease (IHD) before and after conservative or surgical treatment of patients with voiding and storage lower urinary tract symptoms (LTS) due to benign prostatic hyperplasia (BPH).

METHODS

A total of eighty-three 57 to 81-year-old (mean age 70.4 ± 5.75 years) patients with LUTS/BPH and accompanying IHD were examined and treated at the Institute of Urology and Human Reproductive Health and Clinic of Cardiology of Sechenov University. All patients received recommended cardiac therapy at least 6 months before inclusion in the study.

RESULTS

Our study demonstrated that there is correlation between voiding and storage LUTS/BPH and Holter-detected cardiac impairments in patients with IHD/BPH. These data make it possible to consider LUTS/BPH (voiding and storage) as a factor in the additional functional and psychological load on the activity of patients with ischemic heart disease. Improvement of voiding and storage LUTS due to BPH and objective parameters of urination (Qmax) in patients treated with alpha-1 adrenoceptor blocker tamsulosin correlated with improvement of 24-h ECG monitoring parameters (Holter monitoring) in 72% of patients. Improvement of 24-h ECG monitoring parameters (Holter monitoring) 1 month after transurethral resection of the prostate (TURP) in IHD/BPH patients and indications for surgical treatment was observed in 65.7%. Negative dynamics of the Holter-based ECG was not registered in patients who were operated on.

CONCLUSION

Holter monitoring helps to identify groups of patients in whom urinary impairments caused by prostatic hyperplasia negatively affect the course of IHD. Restored urination (either conservatively or operatively) in patients with BPH in 72% of cases decreased the number of fits of angina, thus influencing favourably the course of IHD.

TRIAL REGISTRATION

ClinicalTrials.gov Identifier: NCT03856242.

Authors+Show Affiliations

Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. avinarov@mail.ru.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.Institute of Personalized Medicine, Sechenov University, Moscow, Russia.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.Department of Preventive and Emergency Cardiology, Sechenov University, Moscow, Russia.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.Institute for Urology and Human Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31148056

Citation

Fiev, Dmitrii N., et al. "Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients With Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia." Advances in Therapy, vol. 36, no. 8, 2019, pp. 2072-2085.
Fiev DN, Vinarov AZ, Tsarichenko DG, et al. Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients with Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia. Adv Ther. 2019;36(8):2072-2085.
Fiev, D. N., Vinarov, A. Z., Tsarichenko, D. G., Kopylov, P. Y., Demidko, Y. L., Syrkin, A. L., Rapoport, L. M., Alyaev, Y. G., & Glybochko, P. V. (2019). Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients with Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia. Advances in Therapy, 36(8), 2072-2085. https://doi.org/10.1007/s12325-019-00977-8
Fiev DN, et al. Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients With Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia. Adv Ther. 2019;36(8):2072-2085. PubMed PMID: 31148056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Holter Monitoring (24-Hour ECG) Parameter Dynamics in Patients with Ischemic Heart Disease and Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia. AU - Fiev,Dmitrii N, AU - Vinarov,Andrey Z, AU - Tsarichenko,Dmitrii G, AU - Kopylov,Phillip Yu, AU - Demidko,Yuri L, AU - Syrkin,Abram L, AU - Rapoport,Leonid M, AU - Alyaev,Yuri G, AU - Glybochko,Pyotr V, Y1 - 2019/05/30/ PY - 2019/02/04/received PY - 2019/5/31/pubmed PY - 2020/6/11/medline PY - 2019/6/1/entrez KW - Alpha-1-adrenoblockers KW - Benign prostatic hyperplasia (BPH) KW - Cardiac rhythm KW - Holter monitoring (HM) KW - Ischemic heart disease (IHD) KW - Lower urinary tract symptoms (LUTS) KW - Transurethral resection of the prostate (TURP) KW - Voiding dysfunctions SP - 2072 EP - 2085 JF - Advances in therapy JO - Adv Ther VL - 36 IS - 8 N2 - INTRODUCTION: This study examined the dynamics of 24-h electrocardiogram (ECG) monitoring parameters (Holter monitoring) in patients with ischemic heart disease (IHD) before and after conservative or surgical treatment of patients with voiding and storage lower urinary tract symptoms (LTS) due to benign prostatic hyperplasia (BPH). METHODS: A total of eighty-three 57 to 81-year-old (mean age 70.4 ± 5.75 years) patients with LUTS/BPH and accompanying IHD were examined and treated at the Institute of Urology and Human Reproductive Health and Clinic of Cardiology of Sechenov University. All patients received recommended cardiac therapy at least 6 months before inclusion in the study. RESULTS: Our study demonstrated that there is correlation between voiding and storage LUTS/BPH and Holter-detected cardiac impairments in patients with IHD/BPH. These data make it possible to consider LUTS/BPH (voiding and storage) as a factor in the additional functional and psychological load on the activity of patients with ischemic heart disease. Improvement of voiding and storage LUTS due to BPH and objective parameters of urination (Qmax) in patients treated with alpha-1 adrenoceptor blocker tamsulosin correlated with improvement of 24-h ECG monitoring parameters (Holter monitoring) in 72% of patients. Improvement of 24-h ECG monitoring parameters (Holter monitoring) 1 month after transurethral resection of the prostate (TURP) in IHD/BPH patients and indications for surgical treatment was observed in 65.7%. Negative dynamics of the Holter-based ECG was not registered in patients who were operated on. CONCLUSION: Holter monitoring helps to identify groups of patients in whom urinary impairments caused by prostatic hyperplasia negatively affect the course of IHD. Restored urination (either conservatively or operatively) in patients with BPH in 72% of cases decreased the number of fits of angina, thus influencing favourably the course of IHD. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03856242. SN - 1865-8652 UR - https://www.unboundmedicine.com/medline/citation/31148056/Holter_Monitoring__24_Hour_ECG__Parameter_Dynamics_in_Patients_with_Ischemic_Heart_Disease_and_Lower_Urinary_Tract_Symptoms_Due_to_Benign_Prostatic_Hyperplasia_ L2 - https://dx.doi.org/10.1007/s12325-019-00977-8 DB - PRIME DP - Unbound Medicine ER -