Tags

Type your tag names separated by a space and hit enter

Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar.
Int J Dermatol. 2019 Aug; 58(8):908-911.IJ

Abstract

INTRODUCTION

Vitiligo is a refractory disease in which treatment modalities are not yet established. We aim to assess results obtained 10 years after the initiation of a therapeutic protocol which combines very potent topical corticosteroids (TCS), vitaminotherapy (B12 and C), and suppression of microtraumas in the management of nonsegmental vitiligo in Madagascar.

METHODS

It was a prospective and descriptive study over a period of 6 years (2011-2016) in the Department of Dermatology, Joseph Raseta Befelatanana, Antananarivo, Madagascar. The diagnosis of vitiligo was based on clinical data. Patients who agreed to follow the treatment protocol, which combined very potent TCS (two applications/day for 10 days, and then one application/day for the following 10 days), oral vitamin C 500 mg/day for 20 days, and oral vitamin B12 100 mg/day for 20 days, were included in the study. Two successive courses of treatment were made 10 days apart.

RESULTS

The details of 308 vitiligo patients were analyzed. The mean age of patients was 33.3 years. There was a female preponderance (sex ratio: 0.6). The duration of treatment in our patients varied from 3 to 18 months. Two hundred and thirty-nine patients had good therapeutic compliance and attended regular follow-up. Excellent repigmentation (more than 76% area repigmented) was noted in 50 patients (65.7%) less than 14 years of age. Lesions evolving in less than 1 year in 31 patients (36.9%) had excellent response to treatment. Localized lesions responded favorably to treatment with excellent repigmentation in 108 patients.

CONCLUSION

These results show that therapeutic response is better in young people, lesions less than 1 year of evolution, and for localization of vitiligo in the face and neck.

Authors+Show Affiliations

Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Morafeno, Toamasina, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.Department of Dermatology, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31148154

Citation

Sendrasoa, Fandresena A., et al. "Treatment Responses in Patients With Vitiligo to Very Potent Topical Corticosteroids Combined With Vitaminotherapy in Madagascar." International Journal of Dermatology, vol. 58, no. 8, 2019, pp. 908-911.
Sendrasoa FA, Ranaivo IM, Sata M, et al. Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. Int J Dermatol. 2019;58(8):908-911.
Sendrasoa, F. A., Ranaivo, I. M., Sata, M., Andrianarison, M., Raharolahy, O., Rakotoarisaona, M. F., Razanakoto, N. H., Ramarozatovo, L. S., & Rapelanoro Rabenja, F. (2019). Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. International Journal of Dermatology, 58(8), 908-911. https://doi.org/10.1111/ijd.14510
Sendrasoa FA, et al. Treatment Responses in Patients With Vitiligo to Very Potent Topical Corticosteroids Combined With Vitaminotherapy in Madagascar. Int J Dermatol. 2019;58(8):908-911. PubMed PMID: 31148154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment responses in patients with vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. AU - Sendrasoa,Fandresena A, AU - Ranaivo,Irina M, AU - Sata,Moril, AU - Andrianarison,Malalaniaina, AU - Raharolahy,Onivola, AU - Rakotoarisaona,Mendrika F, AU - Razanakoto,Naina H, AU - Ramarozatovo,Lala S, AU - Rapelanoro Rabenja,Fahafahantsoa, Y1 - 2019/05/31/ PY - 2018/12/11/received PY - 2019/03/22/revised PY - 2019/04/30/accepted PY - 2019/5/31/pubmed PY - 2019/5/31/medline PY - 2019/6/1/entrez SP - 908 EP - 911 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 58 IS - 8 N2 - INTRODUCTION: Vitiligo is a refractory disease in which treatment modalities are not yet established. We aim to assess results obtained 10 years after the initiation of a therapeutic protocol which combines very potent topical corticosteroids (TCS), vitaminotherapy (B12 and C), and suppression of microtraumas in the management of nonsegmental vitiligo in Madagascar. METHODS: It was a prospective and descriptive study over a period of 6 years (2011-2016) in the Department of Dermatology, Joseph Raseta Befelatanana, Antananarivo, Madagascar. The diagnosis of vitiligo was based on clinical data. Patients who agreed to follow the treatment protocol, which combined very potent TCS (two applications/day for 10 days, and then one application/day for the following 10 days), oral vitamin C 500 mg/day for 20 days, and oral vitamin B12 100 mg/day for 20 days, were included in the study. Two successive courses of treatment were made 10 days apart. RESULTS: The details of 308 vitiligo patients were analyzed. The mean age of patients was 33.3 years. There was a female preponderance (sex ratio: 0.6). The duration of treatment in our patients varied from 3 to 18 months. Two hundred and thirty-nine patients had good therapeutic compliance and attended regular follow-up. Excellent repigmentation (more than 76% area repigmented) was noted in 50 patients (65.7%) less than 14 years of age. Lesions evolving in less than 1 year in 31 patients (36.9%) had excellent response to treatment. Localized lesions responded favorably to treatment with excellent repigmentation in 108 patients. CONCLUSION: These results show that therapeutic response is better in young people, lesions less than 1 year of evolution, and for localization of vitiligo in the face and neck. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/31148154/Treatment_responses_in_patients_with_vitiligo_to_very_potent_topical_corticosteroids_combined_with_vitaminotherapy_in_Madagascar L2 - https://doi.org/10.1111/ijd.14510 DB - PRIME DP - Unbound Medicine ER -