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PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS.
Acta Endocrinol (Buchar) 2018 Apr-Jun; 14(2):213-218AE

Abstract

Background

Gestational diabetes mellitus (GDM) is associated with high frequency of obstetric complications, such as gestosis, polyhydramnios, urogenital infection, premature birth. An increase in the number of cases of detection of GDM in pregnant women living in Kazakhstan is noted recently.

Objective

This research was carried out in order to see the influence of GDM on the course of the third trimester of pregnancy, outcomes and fetal status in women of Kazakh ethnic group.

Research design

Cohort observational study.

Subjects and Methods

The main group of research consisted of 61 pregnant women with GDM (Meanage= 32.8±6.314), the control group included 39 pregnant women with normal glucose tolerance (Meanage=30±5.432 years). The pregnant women in both groups were examined by calculation of body mass index (BMI), determination of fasting plasma glucose and the system of hemostasis. Also, the fetal ultrasound was implemented and the uterine-placental, fetal-placental blood flow were evaluated using the Doppler mode.

Results

In the main group initial BMI was equal to Mean=31.1±7.433 kg/m2; we revealed manifestation of gestational hypertension in 36.1%, 95%CI (2.52, 48.6); preeclampsia was diagnosed in 14.8% (95%CI (8; 25.7); the disorders of uteroplacental and fetoplacental blood flow recorded significantly more frequently in main group RR=6.393, 95%CI (1.581-25.840), like the diabetic fetopathy RR=5.115, 95%CI (1.240-21.033). The premature delivery, the prevalence of induction of delivery and intranatal trauma were significantly more frequent in women with GDM.

Conclusions

GDM significantly worsens course of gestation.

Authors+Show Affiliations

Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.Astana Medical University, Dept. of Internal Diseases, Astana, Kazakhstan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31149260

Citation

Meiramova, A, et al. "PECULIARITIES of the COURSE of GESTATION and PREGNANCY OUTCOMES in WOMEN WITH GESTATIONAL DIABETES MELLITUS." Acta Endocrinologica (Bucharest, Romania : 2005), vol. 14, no. 2, 2018, pp. 213-218.
Meiramova A, Ainabekova B, Sadybekova G, et al. PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. Acta Endocrinol (Buchar). 2018;14(2):213-218.
Meiramova, A., Ainabekova, B., Sadybekova, G., Akhmetova, Z., Imangazinova, S., & Omralina, Y. (2018). PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. Acta Endocrinologica (Bucharest, Romania : 2005), 14(2), pp. 213-218. doi:10.4183/aeb.2018.213.
Meiramova A, et al. PECULIARITIES of the COURSE of GESTATION and PREGNANCY OUTCOMES in WOMEN WITH GESTATIONAL DIABETES MELLITUS. Acta Endocrinol (Buchar). 2018;14(2):213-218. PubMed PMID: 31149260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PECULIARITIES OF THE COURSE OF GESTATION AND PREGNANCY OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES MELLITUS. AU - Meiramova,A, AU - Ainabekova,B, AU - Sadybekova,G, AU - Akhmetova,Z, AU - Imangazinova,S, AU - Omralina,Y, PY - 2019/6/1/entrez PY - 2018/4/1/pubmed PY - 2018/4/1/medline KW - Gestational diabetes mellitus KW - assessment of pregnancy KW - pregnancy outcomes SP - 213 EP - 218 JF - Acta endocrinologica (Bucharest, Romania : 2005) JO - Acta Endocrinol (Buchar) VL - 14 IS - 2 N2 - Background: Gestational diabetes mellitus (GDM) is associated with high frequency of obstetric complications, such as gestosis, polyhydramnios, urogenital infection, premature birth. An increase in the number of cases of detection of GDM in pregnant women living in Kazakhstan is noted recently. Objective: This research was carried out in order to see the influence of GDM on the course of the third trimester of pregnancy, outcomes and fetal status in women of Kazakh ethnic group. Research design: Cohort observational study. Subjects and Methods: The main group of research consisted of 61 pregnant women with GDM (Meanage= 32.8±6.314), the control group included 39 pregnant women with normal glucose tolerance (Meanage=30±5.432 years). The pregnant women in both groups were examined by calculation of body mass index (BMI), determination of fasting plasma glucose and the system of hemostasis. Also, the fetal ultrasound was implemented and the uterine-placental, fetal-placental blood flow were evaluated using the Doppler mode. Results: In the main group initial BMI was equal to Mean=31.1±7.433 kg/m2; we revealed manifestation of gestational hypertension in 36.1%, 95%CI (2.52, 48.6); preeclampsia was diagnosed in 14.8% (95%CI (8; 25.7); the disorders of uteroplacental and fetoplacental blood flow recorded significantly more frequently in main group RR=6.393, 95%CI (1.581-25.840), like the diabetic fetopathy RR=5.115, 95%CI (1.240-21.033). The premature delivery, the prevalence of induction of delivery and intranatal trauma were significantly more frequent in women with GDM. Conclusions: GDM significantly worsens course of gestation. SN - 1841-0987 UR - https://www.unboundmedicine.com/medline/citation/31149260/PECULIARITIES_OF_THE_COURSE_OF_GESTATION_AND_PREGNANCY_OUTCOMES_IN_WOMEN_WITH_GESTATIONAL_DIABETES_MELLITUS L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31149260/ DB - PRIME DP - Unbound Medicine ER -