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Subcutaneous nicotine delivery via needle-free jet injection: A porcine model.
J Control Release 2019; 306:83-88JC

Abstract

Subcutaneous delivery of nicotine was performed using a novel electrically-operated needle-free jet injector, and compared to hypodermic needle delivery in a porcine model. Nicotine was delivered as a single, one-milligram dose into the abdominal skin, formulated as a 50 microliter aqueous solution. Plasma levels of nicotine and cotinine, its main metabolite, were then monitored over 2 h, following which the injection site was excised for histological examination. No irritation or tissue damage were found at the injection sites, and the jet-injected nicotine exhibited comparable absorption into the systemic circulation to that injected using a conventional needle and syringe. The needle-free jet injection of nicotine is a promising and well tolerated method. The data presented from this porcine model will support a first in human trial towards a new promising nicotine replacement therapy.

Authors+Show Affiliations

Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Engineering Science, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: b.ruddy@auckland.ac.nz.The National Institute for Health Innovation, School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.The National Institute for Health Innovation, School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.School of Pharmacy, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Department of Pharmacology & Clinical Pharmacology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.Auckland Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Engineering Science, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31150748

Citation

Ruddy, Bryan P., et al. "Subcutaneous Nicotine Delivery Via Needle-free Jet Injection: a Porcine Model." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 306, 2019, pp. 83-88.
Ruddy BP, Bullen C, Chu JTW, et al. Subcutaneous nicotine delivery via needle-free jet injection: A porcine model. J Control Release. 2019;306:83-88.
Ruddy, B. P., Bullen, C., Chu, J. T. W., Jeong, S. H., Madadkhahsalmassi, B., McKeage, J. W., ... Taberner, A. J. (2019). Subcutaneous nicotine delivery via needle-free jet injection: A porcine model. Journal of Controlled Release : Official Journal of the Controlled Release Society, 306, pp. 83-88. doi:10.1016/j.jconrel.2019.05.040.
Ruddy BP, et al. Subcutaneous Nicotine Delivery Via Needle-free Jet Injection: a Porcine Model. J Control Release. 2019 Jul 28;306:83-88. PubMed PMID: 31150748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcutaneous nicotine delivery via needle-free jet injection: A porcine model. AU - Ruddy,Bryan P, AU - Bullen,Chris, AU - Chu,Joanna Ting Wai, AU - Jeong,Soo Hee, AU - Madadkhahsalmassi,Bahareh, AU - McKeage,James W, AU - Svirskis,Darren, AU - Tingle,Malcolm D, AU - Xu,Jiali, AU - Taberner,Andrew J, Y1 - 2019/05/29/ PY - 2018/09/17/received PY - 2019/04/03/revised PY - 2019/05/26/accepted PY - 2019/6/1/pubmed PY - 2019/6/1/medline PY - 2019/6/1/entrez KW - Jet injector KW - Needle-free KW - Nicotine KW - Smoking cessation KW - Subcutaneous SP - 83 EP - 88 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 306 N2 - Subcutaneous delivery of nicotine was performed using a novel electrically-operated needle-free jet injector, and compared to hypodermic needle delivery in a porcine model. Nicotine was delivered as a single, one-milligram dose into the abdominal skin, formulated as a 50 microliter aqueous solution. Plasma levels of nicotine and cotinine, its main metabolite, were then monitored over 2 h, following which the injection site was excised for histological examination. No irritation or tissue damage were found at the injection sites, and the jet-injected nicotine exhibited comparable absorption into the systemic circulation to that injected using a conventional needle and syringe. The needle-free jet injection of nicotine is a promising and well tolerated method. The data presented from this porcine model will support a first in human trial towards a new promising nicotine replacement therapy. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/31150748/Subcutaneous_nicotine_delivery_via_needle-free_jet_injection:_A_porcine_model L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(19)30304-9 DB - PRIME DP - Unbound Medicine ER -