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Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage.
World Neurosurg. 2019 Sep; 129:e472-e477.WN

Abstract

OBJECTIVE

The most potent vasoconstrictor, endothelin-1 and its receptors, endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) are involved in hypertension. Hypertension is a major risk factor of intracerebral hemorrhage (ICH). Recent studies have demonstrated increased plasma endothelin-1 level in ICH patients and relationships between EDNRA and EDNRB genetic variants and ischemic stroke. The aim of the current study was to investigate whether EDNRA and EDNRB polymorphisms are associated with ICH by interacting with blood pressure levels.

METHODS

Five EDNRA and EDNRB polymorphisms were genotyped in this case-control study.

RESULTS

We identified that EDNRA rs5333 T allele might be a protective factor of ICH (adjusted odds ratio [OR] = 0.638, 95% CI: 0.417-0.977, P = 0.038), while EDNRB rs5351 A allele could be a risk factor of ICH (adjusted OR = 1.476, 95% CI: 1.042-2.089, P = 0.028). Moreover, we only found that the GG genotype of EDNRA rs5335 had higher diastolic blood pressure than the GC + CC genotypes in ICH patients (91.69 ± 18.77 vs. 84.71 ± 21.48, P = 0.004).

CONCLUSIONS

These findings support the important role of EDNRA and EDNRB polymorphisms in ICH, and suggest that they do not interact with blood pressure levels on altering ICH risk.

Authors+Show Affiliations

Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zlzdzlzd@csu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31150867

Citation

Zeng, Yi, et al. "Associations of EDNRA and EDNRB Polymorphisms With Intracerebral Hemorrhage." World Neurosurgery, vol. 129, 2019, pp. e472-e477.
Zeng Y, Chen R, Ma M, et al. Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage. World Neurosurg. 2019;129:e472-e477.
Zeng, Y., Chen, R., Ma, M., Liu, B., Xia, J., Xu, H., Liu, Y., Du, X., Hu, Z., Yang, Q., & Zhang, L. (2019). Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage. World Neurosurgery, 129, e472-e477. https://doi.org/10.1016/j.wneu.2019.05.186
Zeng Y, et al. Associations of EDNRA and EDNRB Polymorphisms With Intracerebral Hemorrhage. World Neurosurg. 2019;129:e472-e477. PubMed PMID: 31150867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage. AU - Zeng,Yi, AU - Chen,RuiJuan, AU - Ma,MingMing, AU - Liu,BaoQiong, AU - Xia,Jian, AU - Xu,HongWei, AU - Liu,YunHai, AU - Du,XiaoPing, AU - Hu,ZhiPing, AU - Yang,QiDong, AU - Zhang,Le, Y1 - 2019/05/29/ PY - 2019/04/28/received PY - 2019/05/20/revised PY - 2019/05/22/accepted PY - 2019/6/1/pubmed PY - 2020/1/25/medline PY - 2019/6/1/entrez KW - Blood pressure KW - EDNRA KW - EDNRB KW - Intracerebral hemorrhage KW - Polymorphism SP - e472 EP - e477 JF - World neurosurgery JO - World Neurosurg VL - 129 N2 - OBJECTIVE: The most potent vasoconstrictor, endothelin-1 and its receptors, endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) are involved in hypertension. Hypertension is a major risk factor of intracerebral hemorrhage (ICH). Recent studies have demonstrated increased plasma endothelin-1 level in ICH patients and relationships between EDNRA and EDNRB genetic variants and ischemic stroke. The aim of the current study was to investigate whether EDNRA and EDNRB polymorphisms are associated with ICH by interacting with blood pressure levels. METHODS: Five EDNRA and EDNRB polymorphisms were genotyped in this case-control study. RESULTS: We identified that EDNRA rs5333 T allele might be a protective factor of ICH (adjusted odds ratio [OR] = 0.638, 95% CI: 0.417-0.977, P = 0.038), while EDNRB rs5351 A allele could be a risk factor of ICH (adjusted OR = 1.476, 95% CI: 1.042-2.089, P = 0.028). Moreover, we only found that the GG genotype of EDNRA rs5335 had higher diastolic blood pressure than the GC + CC genotypes in ICH patients (91.69 ± 18.77 vs. 84.71 ± 21.48, P = 0.004). CONCLUSIONS: These findings support the important role of EDNRA and EDNRB polymorphisms in ICH, and suggest that they do not interact with blood pressure levels on altering ICH risk. SN - 1878-8769 UR - https://www.unboundmedicine.com/medline/citation/31150867/Associations_of_EDNRA_and_EDNRB_Polymorphisms_with_Intracerebral_Hemorrhage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1878-8750(19)31463-9 DB - PRIME DP - Unbound Medicine ER -