Tags

Type your tag names separated by a space and hit enter

Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers.
J Infect Dis. 2019 08 30; 220(7):1199-1208.JI

Abstract

BACKGROUND

Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites.

METHODS

A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6-59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm-34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure.

RESULTS

IgG response levels to gSG6-P1 and Nterm-34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods.

CONCLUSIONS

Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs.

Authors+Show Affiliations

MIVEGEC, University of Montpellier, CNRS, IRD. Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire. Biomedical Research Center Espoir Pour La Santé, Saint-Louis, Sénégal.ASTRE, University of Montpellier, CIRAD, INRA, Montpellier. Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.CEPED, University of Paris Descartes, IRD, Paris.Institut Pierre Richet/Institut National de Santé Publique, Bouaké, Côte d'Ivoire.CIIL, Institut Pasteur de Lille, University of Lille, CNRS UMR, Inserm, Lille, France.CIIL, Institut Pasteur de Lille, University of Lille, CNRS UMR, Inserm, Lille, France. Biomedical Research Center Espoir Pour La Santé, Saint-Louis, Sénégal.CEPED, University of Paris Descartes, IRD, Paris.MIVEGEC, University of Montpellier, CNRS, IRD. Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.MIVEGEC, University of Montpellier, CNRS, IRD.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31152664

Citation

Sagna, André B., et al. "Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers." The Journal of Infectious Diseases, vol. 220, no. 7, 2019, pp. 1199-1208.
Sagna AB, Kassié D, Couvray A, et al. Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers. J Infect Dis. 2019;220(7):1199-1208.
Sagna, A. B., Kassié, D., Couvray, A., Adja, A. M., Hermann, E., Riveau, G., Salem, G., Fournet, F., & Remoue, F. (2019). Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers. The Journal of Infectious Diseases, 220(7), 1199-1208. https://doi.org/10.1093/infdis/jiz289
Sagna AB, et al. Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers. J Infect Dis. 2019 08 30;220(7):1199-1208. PubMed PMID: 31152664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spatial Assessment of Contact Between Humans and Anopheles and Aedes Mosquitoes in a Medium-Sized African Urban Setting, Using Salivary Antibody-Based Biomarkers. AU - Sagna,André B, AU - Kassié,Daouda, AU - Couvray,Agnès, AU - Adja,Akré Maurice, AU - Hermann,Emmanuel, AU - Riveau,Gilles, AU - Salem,Gérard, AU - Fournet,Florence, AU - Remoue,Franck, PY - 2019/02/06/received PY - 2019/05/30/accepted PY - 2019/6/4/pubmed PY - 2020/5/28/medline PY - 2019/6/2/entrez KW - Aedes KW - Anopheles KW - MBD risk KW - Nterm–34-kD KW - Urban area KW - gSG6-P1 KW - salivary biomarkers SP - 1199 EP - 1208 JF - The Journal of infectious diseases JO - J Infect Dis VL - 220 IS - 7 N2 - BACKGROUND: Anarchic and poorly controlled urbanization led to an increased risk of mosquito-borne diseases (MBD) in many African cities. Here, we evaluate the spatial heterogeneity of human exposure to malaria and arboviral disease vectors in an urban area of northern Senegal, using antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites. METHODS: A cross-sectional study was undertaken during the rainy season of 2014 in 4 neighborhoods of Saint-Louis, a city in northern Senegal. Among children aged 6-59 months in each neighborhood, the dried blood spot technique was used to evaluate immunoglobulin G (IgG) responses to both gSG6-P1 (Anopheles) and Nterm-34-kDa (Aedes) salivary peptides as validated biomarkers of respective mosquito bite exposure. RESULTS: IgG response levels to gSG6-P1 and Nterm-34-kDa salivary peptides varied significantly between the 4 neighborhoods (P < .0001). The level of exposure to Aedes bites also varied according to household access to sanitation services (P = .027), whereas that of exposure to Anopheles bites varied according to insecticide-treated bed net use (P = .006). In addition, spatial clusters of high contact between humans and mosquitoes were identified inside 3 neighborhoods. CONCLUSIONS: Antibody-based biomarkers of exposure to Anopheles and Aedes mosquito bites could be helpful tools for evaluating the heterogeneity of exposure to malaria and arboviral disease vectors by national control programs. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/31152664/Spatial_Assessment_of_Contact_Between_Humans_and_Anopheles_and_Aedes_Mosquitoes_in_a_Medium_Sized_African_Urban_Setting_Using_Salivary_Antibody_Based_Biomarkers_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiz289 DB - PRIME DP - Unbound Medicine ER -