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Diagnostic values and appropriate cutoff points of lipid ratios in patients with abnormal glucose tolerance status: a cross-sectional study.
Lipids Health Dis. 2019 Jun 01; 18(1):130.LH

Abstract

BACKGROUND

Lipid ratios, for example total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), are associated with type 2 diabetes mellitus (T2DM). However, the predictive values of lipid ratios in prediabetes remain unclear. The aims of this study were: 1) to investigate the association between lipid ratios and abnormal glucose tolerance; 2) to compare the predictive significance of lipid ratios with commonly used indicators of lipid variables in clinical practice in a Chinese population.

METHODS

The cross-sectional study enrolled 2680 participants from the Health Promotion Center of the First Affiliated Hospital of Nanjing Medical University. All participants received a 75 g oral glucose tolerance test. Blood samples were obtained at baseline and 120 min after glucose ingestion. Participants were classified as normal glucose tolerance (NGT), impaired glucose regulation (IGR), and T2DM. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression model. The receiver operating characteristic (ROC) curve was used to identify the cutoff points of lipid and lipid ratios. The area under the receiver operating characteristic curve (AUROC), sensitivity and specificity were calculated to estimate their diagnostic values.

RESULTS

TC, TG, TC/HDL-C, TG/HDL-C and non-HDL-C were significantly correlated with both prediabetes and T2DM after adjustment for other risk factors such as blood glucose, whereas LDL-C was only positively correlated with prediabetes. TG and TG/HDL-C showed higher diagnostic values for prediabetes and T2DM than TC, LDL-C, HDL-C, TC/HDL-C and non-HDL-C, with the AUC values over 0.70. For predicting prediabetes, the optimal cutoff point was 1.36 mmol/l for TG and 1.13 for TG/HDL-C. For predicting T2DM, the optimal cutoff point was 1.46 mmol/l for TG and 1.22 for TG/HDL-C.

CONCLUSIONS

Both TG and TG/HDL-C are promising biomarkers for distinguishing individuals with abnormal glucose tolerance, and can be used to predict prediabetes and T2DM in Chinese population.

Authors+Show Affiliations

Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.School of Public Health, Nanjing Medical University, 818 Tianyuan East Road, Nanjing, 211166, China. 420135609@qq.com.Department of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China. wenzi20100305@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31153374

Citation

Guo, Wen, et al. "Diagnostic Values and Appropriate Cutoff Points of Lipid Ratios in Patients With Abnormal Glucose Tolerance Status: a Cross-sectional Study." Lipids in Health and Disease, vol. 18, no. 1, 2019, p. 130.
Guo W, Qin P, Lu J, et al. Diagnostic values and appropriate cutoff points of lipid ratios in patients with abnormal glucose tolerance status: a cross-sectional study. Lipids Health Dis. 2019;18(1):130.
Guo, W., Qin, P., Lu, J., Li, X., Zhu, W., Xu, N., Wang, J., & Zhang, Q. (2019). Diagnostic values and appropriate cutoff points of lipid ratios in patients with abnormal glucose tolerance status: a cross-sectional study. Lipids in Health and Disease, 18(1), 130. https://doi.org/10.1186/s12944-019-1070-z
Guo W, et al. Diagnostic Values and Appropriate Cutoff Points of Lipid Ratios in Patients With Abnormal Glucose Tolerance Status: a Cross-sectional Study. Lipids Health Dis. 2019 Jun 1;18(1):130. PubMed PMID: 31153374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic values and appropriate cutoff points of lipid ratios in patients with abnormal glucose tolerance status: a cross-sectional study. AU - Guo,Wen, AU - Qin,Pei, AU - Lu,Jing, AU - Li,Xiaona, AU - Zhu,Wenfang, AU - Xu,Nianzhen, AU - Wang,Jianming, AU - Zhang,Qun, Y1 - 2019/06/01/ PY - 2018/12/19/received PY - 2019/05/17/accepted PY - 2019/6/3/entrez PY - 2019/6/4/pubmed PY - 2019/12/18/medline KW - Diabetes KW - Dyslipidemia KW - Glucose tolerance KW - Lipid ratio SP - 130 EP - 130 JF - Lipids in health and disease JO - Lipids Health Dis VL - 18 IS - 1 N2 - BACKGROUND: Lipid ratios, for example total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C), are associated with type 2 diabetes mellitus (T2DM). However, the predictive values of lipid ratios in prediabetes remain unclear. The aims of this study were: 1) to investigate the association between lipid ratios and abnormal glucose tolerance; 2) to compare the predictive significance of lipid ratios with commonly used indicators of lipid variables in clinical practice in a Chinese population. METHODS: The cross-sectional study enrolled 2680 participants from the Health Promotion Center of the First Affiliated Hospital of Nanjing Medical University. All participants received a 75 g oral glucose tolerance test. Blood samples were obtained at baseline and 120 min after glucose ingestion. Participants were classified as normal glucose tolerance (NGT), impaired glucose regulation (IGR), and T2DM. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression model. The receiver operating characteristic (ROC) curve was used to identify the cutoff points of lipid and lipid ratios. The area under the receiver operating characteristic curve (AUROC), sensitivity and specificity were calculated to estimate their diagnostic values. RESULTS: TC, TG, TC/HDL-C, TG/HDL-C and non-HDL-C were significantly correlated with both prediabetes and T2DM after adjustment for other risk factors such as blood glucose, whereas LDL-C was only positively correlated with prediabetes. TG and TG/HDL-C showed higher diagnostic values for prediabetes and T2DM than TC, LDL-C, HDL-C, TC/HDL-C and non-HDL-C, with the AUC values over 0.70. For predicting prediabetes, the optimal cutoff point was 1.36 mmol/l for TG and 1.13 for TG/HDL-C. For predicting T2DM, the optimal cutoff point was 1.46 mmol/l for TG and 1.22 for TG/HDL-C. CONCLUSIONS: Both TG and TG/HDL-C are promising biomarkers for distinguishing individuals with abnormal glucose tolerance, and can be used to predict prediabetes and T2DM in Chinese population. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/31153374/Diagnostic_values_and_appropriate_cutoff_points_of_lipid_ratios_in_patients_with_abnormal_glucose_tolerance_status:_a_cross_sectional_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1070-z DB - PRIME DP - Unbound Medicine ER -