Tags

Type your tag names separated by a space and hit enter

Imaging liver nodules in tyrosinemia type-1: A retrospective review of 16 cases in a tertiary pediatric hospital.
Eur J Radiol 2019; 116:41-46EJ

Abstract

OBJECTIVE

To describe the liver imaging findings of Hereditary tyrosinemia type-1 (HT1) patients.

MATERIALS AND METHODS

We report 16 patients (8 Female and 8 Male) with HT-1. Their demographic features, imaging findings and alpha feto protein (AFP) levels were recorded. Imaging features on CT and MR were evaluated for the following characteristics: contour of the liver and liver nodules. Liver nodules were categorized as; regenerative, dysplastic, fatty and malignant nodules (HCC).

RESULTS

Thirteen (81%) patients had multiple liver nodules (>20) on imaging studies. Five patients (31%) had regenerative nodules, six (38%) had dysplastic nodules and ten (63%) had fatty nodules. Dysplastic nodules were encountered in two patients with HCC and in four patients without a tumor. Four patients (25%) had HCC nodule on imaging studies. Those four patients had biopsy and all of them had HCC nodule on histopathology. In the follow-up period, in one patient fatty nodules had increased in size, in one patient regenerative nodules had disappeared and in one patient dysplastic nodules had disappeared.

CONCLUSIONS

Multiple fatty nodules can be seen in HT1 patients and in some patients, the regenerative and dysplastic nodules can disappear during the follow-up period.

Authors+Show Affiliations

Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey. Electronic address: drhnozcan@yahoo.com.Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey.Department of Pediatrics, Division of Pediatric Metabolic Diseases, Cengiz Gokcek Children Hospital Gaziantep, Turkey.Department of Pediatrics, Division of Pediatric Metabolic Diseases, Hacettepe University School of Medicine Ankara, Turkey.Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey.Department of Pediatrics, Division of Pediatric Metabolic Diseases, Hacettepe University School of Medicine Ankara, Turkey.Department of Pediatrics, Division of Pediatric Metabolic Diseases, Hacettepe University School of Medicine Ankara, Turkey.Department of Pediatrics, Division of Pediatric Metabolic Diseases, Hacettepe University School of Medicine Ankara, Turkey.Department of Radiology, Hacettepe University School of Medicine Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31153572

Citation

Ozcan, H Nursun, et al. "Imaging Liver Nodules in Tyrosinemia Type-1: a Retrospective Review of 16 Cases in a Tertiary Pediatric Hospital." European Journal of Radiology, vol. 116, 2019, pp. 41-46.
Ozcan HN, Karcaaltincaba M, Pektas E, et al. Imaging liver nodules in tyrosinemia type-1: A retrospective review of 16 cases in a tertiary pediatric hospital. Eur J Radiol. 2019;116:41-46.
Ozcan, H. N., Karcaaltincaba, M., Pektas, E., Sivri, H. S., Oguz, B., Dursun, A., ... Haliloglu, M. (2019). Imaging liver nodules in tyrosinemia type-1: A retrospective review of 16 cases in a tertiary pediatric hospital. European Journal of Radiology, 116, pp. 41-46. doi:10.1016/j.ejrad.2019.04.016.
Ozcan HN, et al. Imaging Liver Nodules in Tyrosinemia Type-1: a Retrospective Review of 16 Cases in a Tertiary Pediatric Hospital. Eur J Radiol. 2019;116:41-46. PubMed PMID: 31153572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Imaging liver nodules in tyrosinemia type-1: A retrospective review of 16 cases in a tertiary pediatric hospital. AU - Ozcan,H Nursun, AU - Karcaaltincaba,Musturay, AU - Pektas,Emine, AU - Sivri,H Serap, AU - Oguz,Berna, AU - Dursun,Ali, AU - Tokatli,Aysegul, AU - Coskun,Turgay, AU - Haliloglu,Mithat, Y1 - 2019/04/23/ PY - 2019/01/05/received PY - 2019/03/07/revised PY - 2019/04/23/accepted PY - 2019/6/3/entrez KW - Liver KW - Magnetic resonance imaging KW - Tyrosinemia type 1 SP - 41 EP - 46 JF - European journal of radiology JO - Eur J Radiol VL - 116 N2 - OBJECTIVE: To describe the liver imaging findings of Hereditary tyrosinemia type-1 (HT1) patients. MATERIALS AND METHODS: We report 16 patients (8 Female and 8 Male) with HT-1. Their demographic features, imaging findings and alpha feto protein (AFP) levels were recorded. Imaging features on CT and MR were evaluated for the following characteristics: contour of the liver and liver nodules. Liver nodules were categorized as; regenerative, dysplastic, fatty and malignant nodules (HCC). RESULTS: Thirteen (81%) patients had multiple liver nodules (>20) on imaging studies. Five patients (31%) had regenerative nodules, six (38%) had dysplastic nodules and ten (63%) had fatty nodules. Dysplastic nodules were encountered in two patients with HCC and in four patients without a tumor. Four patients (25%) had HCC nodule on imaging studies. Those four patients had biopsy and all of them had HCC nodule on histopathology. In the follow-up period, in one patient fatty nodules had increased in size, in one patient regenerative nodules had disappeared and in one patient dysplastic nodules had disappeared. CONCLUSIONS: Multiple fatty nodules can be seen in HT1 patients and in some patients, the regenerative and dysplastic nodules can disappear during the follow-up period. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/31153572/Imaging_liver_nodules_in_tyrosinemia_type-1:_A_retrospective_review_of_16_cases_in_a_tertiary_pediatric_hospital L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(19)30150-0 DB - PRIME DP - Unbound Medicine ER -