Tags

Type your tag names separated by a space and hit enter

Anxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine condition.
J Ethnopharmacol 2019; 241:112006JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Montanoa tomentosa Cerv. (MT) is a native plant from Mexico used in traditional medicine as a remedy for reproductive impairments and relaxing effects. In previous studies, it has been shown that the endocrine state could modify the antianxiety-like actions of anxiolytic compounds. Although women are the primary user of MT, no studies have evaluated the potential impact of the endocrine milieu on its anti-anxiety actions.

AIMS OF THE STUDY

Ascertain the antianxiety effects of M. tomentosa in rats with different hormonal conditions, and to analyze the participation of the GABAA receptor in ovariectomized rats treated with MT.

MATERIALS AND METHODS

The animal model of anxiety used was the elevated plus-maze (EPM). Rats' endocrine conditions were: a) Low hormone levels (rats in diestrus I and II phases); b) High hormone levels (proestrus/estrus phases); c) No hormones (ovariectomized rats); and d) Rats under progesterone withdrawal (PW). To evaluate the participation of the GABAA receptor in the anxiolytic-like action of MT the antagonist picrotoxin was used.

RESULTS

Results showed that MT induced dose-dependent anxiolytic-like actions in rats with low hormone level conditions. Also, MT reduced anxiety-like behavior in female rats under PW, in contrast to diazepam which was ineffective. MT's anxiolytic-like effect was blocked by picrotoxin, suggesting the participation of the GABAA receptor complex. However, increased anxiety-like behavior was observed in rats with a high hormone level condition and low doses of MT.

CONCLUSIONS

Beneficial anxiolytic-like actions of MT are observed under low hormone conditions, particularly in the PW challenge (a condition that can be related to a premenstrual period). Furthermore, the participation of the GABAA receptor is evidenced. However, hormonal variations could induce the opposite effects, hence women should be cautious.

Authors+Show Affiliations

Laboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Calzada México Xochimilco 101, Col San Lorenzo Huipulco, Delegación Tlalpan, Ciudad de México, Mexico. Electronic address: estrada@imp.edu.mx.Departamento de Farmacobiología, CINVESTAV-Sede Sur. Calzada de los Tenorios 235, Col Granjas Coapa, Delegación Tlalpan, Ciudad de México, Mexico. Electronic address: sodi8507@gmail.com.Laboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Calzada México Xochimilco 101, Col San Lorenzo Huipulco, Delegación Tlalpan, Ciudad de México, Mexico. Electronic address: dannia.islas@hotmail.com.Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñíz", Calzada México, Xochimilco 101, Col San Lorenzo Huipulco, Delegación Tlalpan, Ciudad de México, Mexico. Electronic address: evag@imp.edu.mx.Facultad de Veterinaria, Universidad autónoma de Tlaxcala, Tlaxcala, Mexico.Departamento de Farmacobiología, CINVESTAV-Sede Sur. Calzada de los Tenorios 235, Col Granjas Coapa, Delegación Tlalpan, Ciudad de México, Mexico. Electronic address: clopezr@cinvestav.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31153863

Citation

Estrada-Camarena, Erika, et al. "Anxiolytic- and Anxiogenic-like Effects of Montanoa Tomentosa (Asteraceae): Dependence On the Endocrine Condition." Journal of Ethnopharmacology, vol. 241, 2019, p. 112006.
Estrada-Camarena E, Sollozo-Dupont I, Islas-Preciado D, et al. Anxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine condition. J Ethnopharmacol. 2019;241:112006.
Estrada-Camarena, E., Sollozo-Dupont, I., Islas-Preciado, D., González-Trujano, M. E., Carro-Juárez, M., & López-Rubalcava, C. (2019). Anxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine condition. Journal of Ethnopharmacology, 241, p. 112006. doi:10.1016/j.jep.2019.112006.
Estrada-Camarena E, et al. Anxiolytic- and Anxiogenic-like Effects of Montanoa Tomentosa (Asteraceae): Dependence On the Endocrine Condition. J Ethnopharmacol. 2019 Sep 15;241:112006. PubMed PMID: 31153863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine condition. AU - Estrada-Camarena,Erika, AU - Sollozo-Dupont,Isabel, AU - Islas-Preciado,Dannia, AU - González-Trujano,María Eva, AU - Carro-Juárez,Miguel, AU - López-Rubalcava,Carolina, Y1 - 2019/05/30/ PY - 2019/02/11/received PY - 2019/05/28/revised PY - 2019/05/29/accepted PY - 2019/6/4/pubmed PY - 2019/6/4/medline PY - 2019/6/3/entrez KW - Anxiolytic-like effect KW - Elevated plus-maze KW - Estrous cycle KW - GABA(A) receptor KW - Montanoa tomentosa KW - Progesterone withdrawal SP - 112006 EP - 112006 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 241 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Montanoa tomentosa Cerv. (MT) is a native plant from Mexico used in traditional medicine as a remedy for reproductive impairments and relaxing effects. In previous studies, it has been shown that the endocrine state could modify the antianxiety-like actions of anxiolytic compounds. Although women are the primary user of MT, no studies have evaluated the potential impact of the endocrine milieu on its anti-anxiety actions. AIMS OF THE STUDY: Ascertain the antianxiety effects of M. tomentosa in rats with different hormonal conditions, and to analyze the participation of the GABAA receptor in ovariectomized rats treated with MT. MATERIALS AND METHODS: The animal model of anxiety used was the elevated plus-maze (EPM). Rats' endocrine conditions were: a) Low hormone levels (rats in diestrus I and II phases); b) High hormone levels (proestrus/estrus phases); c) No hormones (ovariectomized rats); and d) Rats under progesterone withdrawal (PW). To evaluate the participation of the GABAA receptor in the anxiolytic-like action of MT the antagonist picrotoxin was used. RESULTS: Results showed that MT induced dose-dependent anxiolytic-like actions in rats with low hormone level conditions. Also, MT reduced anxiety-like behavior in female rats under PW, in contrast to diazepam which was ineffective. MT's anxiolytic-like effect was blocked by picrotoxin, suggesting the participation of the GABAA receptor complex. However, increased anxiety-like behavior was observed in rats with a high hormone level condition and low doses of MT. CONCLUSIONS: Beneficial anxiolytic-like actions of MT are observed under low hormone conditions, particularly in the PW challenge (a condition that can be related to a premenstrual period). Furthermore, the participation of the GABAA receptor is evidenced. However, hormonal variations could induce the opposite effects, hence women should be cautious. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/31153863/Anxiolytic-_and_anxiogenic-like_effects_of_Montanoa_tomentosa_(Asteraceae):_Dependence_on_the_endocrine_condition L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(19)30585-9 DB - PRIME DP - Unbound Medicine ER -