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Mycobacterial carbohydrate antigens for serological testing of patients with leprosy.
J Infect Dis. 1987 Nov; 156(5):763-9.JI

Abstract

To determine whether quantitation of antibodies to mycobacterial carbohydrate determinants would be valuable in serodiagnosis and monitoring of leprosy, we tested serum IgM antibody to Mycobacterium leprae phenolic glycolipid I and IgM and IgG antibodies to Mycobacterium tuberculosis and M. leprae lipoarabinomannan (LAM) by enzyme-linked immunosorbent assay. Seventy-one percent of patients with paucibacillary disease and 85.5% of patients with multibacillary disease were positive for at least one of the three antibodies. The 15% of antibody-negative patients with multibacillary disease were mostly long-term-treated patients, with inactive disease by biopsy. There was excellent agreement between M. tuberculosis LAM and M. leprae LAM in detection of antibodies. Bacillary index and levels of both IgG and IgM antibodies to LAM were positively correlated when all patients were analyzed. When patients with a history of erythema nodosum leprosum (ENL) were analyzed separately, there was no correlation between IgM or IgG antibody to LAM and bacillary index, a result suggesting a possible role for LAM in the pathogenesis of ENL.

Authors+Show Affiliations

Levis WR
Department of Dermatology, New York Medical College.
Meeker HC
No affiliation info available
Schuller-Levis G
No affiliation info available
Sersen E
No affiliation info available
Brennan PJ
No affiliation info available
Fried P
No affiliation info available

MeSH

Antibodies, BacterialAntigens, BacterialEnzyme-Linked Immunosorbent AssayGlycolipidsHumansImmunoglobulin GImmunoglobulin MLeprosyLipopolysaccharidesMycobacterium lepraeMycobacterium tuberculosis

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3116103

Citation

Levis, W R., et al. "Mycobacterial Carbohydrate Antigens for Serological Testing of Patients With Leprosy." The Journal of Infectious Diseases, vol. 156, no. 5, 1987, pp. 763-9.
Levis WR, Meeker HC, Schuller-Levis G, et al. Mycobacterial carbohydrate antigens for serological testing of patients with leprosy. J Infect Dis. 1987;156(5):763-9.
Levis, W. R., Meeker, H. C., Schuller-Levis, G., Sersen, E., Brennan, P. J., & Fried, P. (1987). Mycobacterial carbohydrate antigens for serological testing of patients with leprosy. The Journal of Infectious Diseases, 156(5), 763-9.
Levis WR, et al. Mycobacterial Carbohydrate Antigens for Serological Testing of Patients With Leprosy. J Infect Dis. 1987;156(5):763-9. PubMed PMID: 3116103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycobacterial carbohydrate antigens for serological testing of patients with leprosy. AU - Levis,W R, AU - Meeker,H C, AU - Schuller-Levis,G, AU - Sersen,E, AU - Brennan,P J, AU - Fried,P, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 763 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 156 IS - 5 N2 - To determine whether quantitation of antibodies to mycobacterial carbohydrate determinants would be valuable in serodiagnosis and monitoring of leprosy, we tested serum IgM antibody to Mycobacterium leprae phenolic glycolipid I and IgM and IgG antibodies to Mycobacterium tuberculosis and M. leprae lipoarabinomannan (LAM) by enzyme-linked immunosorbent assay. Seventy-one percent of patients with paucibacillary disease and 85.5% of patients with multibacillary disease were positive for at least one of the three antibodies. The 15% of antibody-negative patients with multibacillary disease were mostly long-term-treated patients, with inactive disease by biopsy. There was excellent agreement between M. tuberculosis LAM and M. leprae LAM in detection of antibodies. Bacillary index and levels of both IgG and IgM antibodies to LAM were positively correlated when all patients were analyzed. When patients with a history of erythema nodosum leprosum (ENL) were analyzed separately, there was no correlation between IgM or IgG antibody to LAM and bacillary index, a result suggesting a possible role for LAM in the pathogenesis of ENL. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/3116103/Mycobacterial_carbohydrate_antigens_for_serological_testing_of_patients_with_leprosy_ DB - PRIME DP - Unbound Medicine ER -