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Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities.
Ocul Immunol Inflamm. 2020 Apr 02; 28(3):453-462.OI

Abstract

Purpose:

To evaluate expression of cytokines GM-CSF, IL-11, IL-12p40, IL-12p70, IL-27p28, IL-35, APRIL, BAFF, TWEAK, and LIGHT in uveitis.

Methods:

Aqueous humor samples from patients with active uveitis associated with Behçet's disease (BD), sarcoidosis, HLA-B27-related inflammation, and Vogt-Koyanagi-Harada (VKH) disease and control patients were assayed with a multiplex assay.

Results:

Comparing all patients to controls, GM-CSF, IL-11, IL-12p40, APRIL, and BAFF were significantly increased, whereas LIGHT was significantly decreased. IL-11 and BAFF were the most strongly upregulated, being elevated 19.7-fold and 14.1-fold, respectively, compared with controls. IL-11 was significantly highest in HLA-B27 uveitis. GM-CSF, IL-11, and IL-12p40 were significantly higher in nongranulomatous uveitis (BD and HLA-B27) than in granulomatous uveitis (sarcoidosis and VKH), whereas APRIL and TWEAK were significantly higher in granulomatous uveitis.

Conclusions:

IL-11-driven immune responses might be more potent in nongranulomatous uveitis, particularly in HLA-B27 uveitis. BAFF and APRIL might contribute to B cell-driven autoimmune response in uveitis.

Authors+Show Affiliations

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Dr. Nasser Al-Rashid Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Laboratory of Immunobiology, Rega Institute for Medical Research and Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.Laboratory of Immunobiology, Rega Institute for Medical Research and Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Laboratory of Immunobiology, Rega Institute for Medical Research and Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.Laboratory of Immunobiology, Rega Institute for Medical Research and Department of Microbiology and Immunology, University of Leuven, KU Leuven, Leuven, Belgium.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31161935

Citation

Abu El-Asrar, Ahmed M., et al. "Local Cytokine Expression Profiling in Patients With Specific Autoimmune Uveitic Entities." Ocular Immunology and Inflammation, vol. 28, no. 3, 2020, pp. 453-462.
Abu El-Asrar AM, Berghmans N, Al-Obeidan SA, et al. Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities. Ocul Immunol Inflamm. 2020;28(3):453-462.
Abu El-Asrar, A. M., Berghmans, N., Al-Obeidan, S. A., Gikandi, P. W., Opdenakker, G., Van Damme, J., & Struyf, S. (2020). Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities. Ocular Immunology and Inflammation, 28(3), 453-462. https://doi.org/10.1080/09273948.2019.1604974
Abu El-Asrar AM, et al. Local Cytokine Expression Profiling in Patients With Specific Autoimmune Uveitic Entities. Ocul Immunol Inflamm. 2020 Apr 2;28(3):453-462. PubMed PMID: 31161935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities. AU - Abu El-Asrar,Ahmed M, AU - Berghmans,Nele, AU - Al-Obeidan,Saleh A, AU - Gikandi,Priscilla W, AU - Opdenakker,Ghislain, AU - Van Damme,Jo, AU - Struyf,Sofie, Y1 - 2019/06/04/ PY - 2019/6/5/pubmed PY - 2020/4/14/medline PY - 2019/6/5/entrez KW - Behçet’s disease KW - HLA-B27 KW - Vogt-Koyanagi-Harada disease KW - cytokines KW - sarcoidosis KW - uveitis SP - 453 EP - 462 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. VL - 28 IS - 3 N2 - Purpose: To evaluate expression of cytokines GM-CSF, IL-11, IL-12p40, IL-12p70, IL-27p28, IL-35, APRIL, BAFF, TWEAK, and LIGHT in uveitis.Methods: Aqueous humor samples from patients with active uveitis associated with Behçet's disease (BD), sarcoidosis, HLA-B27-related inflammation, and Vogt-Koyanagi-Harada (VKH) disease and control patients were assayed with a multiplex assay.Results: Comparing all patients to controls, GM-CSF, IL-11, IL-12p40, APRIL, and BAFF were significantly increased, whereas LIGHT was significantly decreased. IL-11 and BAFF were the most strongly upregulated, being elevated 19.7-fold and 14.1-fold, respectively, compared with controls. IL-11 was significantly highest in HLA-B27 uveitis. GM-CSF, IL-11, and IL-12p40 were significantly higher in nongranulomatous uveitis (BD and HLA-B27) than in granulomatous uveitis (sarcoidosis and VKH), whereas APRIL and TWEAK were significantly higher in granulomatous uveitis.Conclusions: IL-11-driven immune responses might be more potent in nongranulomatous uveitis, particularly in HLA-B27 uveitis. BAFF and APRIL might contribute to B cell-driven autoimmune response in uveitis. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/31161935/Local_Cytokine_Expression_Profiling_in_Patients_with_Specific_Autoimmune_Uveitic_Entities_ L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2019.1604974 DB - PRIME DP - Unbound Medicine ER -