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Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature.
Clin Ther 2019; 41(8):1614-1620CT

Abstract

PURPOSE

Propafenone hydrochloride has been widely used for the treatment of supraventricular and ventricular arrhythmias. We present a case report of an 81-year-old patient with propafenone-associated gross hematuria.

METHODS

The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality. We also performed a literature search to find publications that report propafenone-associated gross hematuria.

FINDINGS

The Naranjo scale generated a score of 6, suggesting a probable association between gross hematuria and propafenone therapy. Thirteen publications that reported an association between gross hematuria and propafenone administration were found.

IMPLICATIONS

A probable association exists between gross hematuria and propafenone.

Authors+Show Affiliations

Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China.Department of Pharmacy, Base for Clinical Trial, Peking University First Hospital, Beijing, China. Electronic address: bdyyyljd@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31164244

Citation

Chen, Shuqing, et al. "Propafenone-associated Gross Hematuria: a Case Report and Review of the Literature." Clinical Therapeutics, vol. 41, no. 8, 2019, pp. 1614-1620.
Chen S, Ding W, Ye J, et al. Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature. Clin Ther. 2019;41(8):1614-1620.
Chen, S., Ding, W., Ye, J., Wang, Z., Zhao, X., & Cui, Y. (2019). Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature. Clinical Therapeutics, 41(8), pp. 1614-1620. doi:10.1016/j.clinthera.2019.05.002.
Chen S, et al. Propafenone-associated Gross Hematuria: a Case Report and Review of the Literature. Clin Ther. 2019;41(8):1614-1620. PubMed PMID: 31164244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature. AU - Chen,Shuqing, AU - Ding,Wenhui, AU - Ye,Jing, AU - Wang,Zining, AU - Zhao,Xia, AU - Cui,Yimin, Y1 - 2019/06/01/ PY - 2019/02/22/received PY - 2019/04/26/revised PY - 2019/05/06/accepted PY - 2019/6/6/pubmed PY - 2019/6/6/medline PY - 2019/6/6/entrez KW - antiarrhythmic medication KW - gross hematuria KW - paroxysmal atrial fibrillation KW - propafenone SP - 1614 EP - 1620 JF - Clinical therapeutics JO - Clin Ther VL - 41 IS - 8 N2 - PURPOSE: Propafenone hydrochloride has been widely used for the treatment of supraventricular and ventricular arrhythmias. We present a case report of an 81-year-old patient with propafenone-associated gross hematuria. METHODS: The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality. We also performed a literature search to find publications that report propafenone-associated gross hematuria. FINDINGS: The Naranjo scale generated a score of 6, suggesting a probable association between gross hematuria and propafenone therapy. Thirteen publications that reported an association between gross hematuria and propafenone administration were found. IMPLICATIONS: A probable association exists between gross hematuria and propafenone. SN - 1879-114X UR - https://www.unboundmedicine.com/medline/citation/31164244/Propafenone-associated_Gross_Hematuria:_A_Case_Report_and_Review_of_the_Literature L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-2918(19)30247-4 DB - PRIME DP - Unbound Medicine ER -