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Matrix metalloproteinases in the CNS: interferons get nervous.
Cell Mol Life Sci. 2019 Aug; 76(16):3083-3095.CM

Abstract

Matrix metalloproteinases (MMPs) have been investigated in context of chronic inflammatory diseases and demonstrated to degrade multiple components of the extracellular matrix (ECM). However, following several disappointing MMP clinical trials, recent studies have demonstrated unexpected novel functions of MMPs in viral infections and autoimmune inflammatory diseases in unanticipated locations. Thus, MMPs play additional functions in inflammation than just ECM degradation. They can regulate the activity of chemokines and cytokines of the immune response by precise proteolytic processing resulting in activation or inactivation of signaling pathways. MMPs have been demonstrated to cleave multiple substrates of the central nervous systems (CNS) and contribute to promoting and dampening diseases of the CNS. Initially, believed to be solely promoting pathologies, more than 10 MMPs to date have been shown to have protective functions. Here, we present some of the beneficial and destructive roles of MMPs in CNS pathologies and discuss strategies for the use of MMP inhibitors.

Authors+Show Affiliations

Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, T2N 4N1, Canada.Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Centre for Blood Research, Vancouver, BC, V6T 1Z3, Canada.Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. antoine.dufour@ucalgary.ca. McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB, T2N 4N1, Canada. antoine.dufour@ucalgary.ca.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31165203

Citation

Chopra, Sameeksha, et al. "Matrix Metalloproteinases in the CNS: Interferons Get Nervous." Cellular and Molecular Life Sciences : CMLS, vol. 76, no. 16, 2019, pp. 3083-3095.
Chopra S, Overall CM, Dufour A. Matrix metalloproteinases in the CNS: interferons get nervous. Cell Mol Life Sci. 2019;76(16):3083-3095.
Chopra, S., Overall, C. M., & Dufour, A. (2019). Matrix metalloproteinases in the CNS: interferons get nervous. Cellular and Molecular Life Sciences : CMLS, 76(16), 3083-3095. https://doi.org/10.1007/s00018-019-03171-9
Chopra S, Overall CM, Dufour A. Matrix Metalloproteinases in the CNS: Interferons Get Nervous. Cell Mol Life Sci. 2019;76(16):3083-3095. PubMed PMID: 31165203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinases in the CNS: interferons get nervous. AU - Chopra,Sameeksha, AU - Overall,Christopher M, AU - Dufour,Antoine, Y1 - 2019/06/04/ PY - 2019/05/22/received PY - 2019/05/29/accepted PY - 2019/05/22/revised PY - 2019/6/6/pubmed PY - 2019/7/30/medline PY - 2019/6/6/entrez KW - Extracellular matrix (ECM) KW - Inflammation KW - Interferon (IFN) KW - Matrix metalloproteinase (MMP) KW - Multiple sclerosis (MS) KW - Virus SP - 3083 EP - 3095 JF - Cellular and molecular life sciences : CMLS JO - Cell. Mol. Life Sci. VL - 76 IS - 16 N2 - Matrix metalloproteinases (MMPs) have been investigated in context of chronic inflammatory diseases and demonstrated to degrade multiple components of the extracellular matrix (ECM). However, following several disappointing MMP clinical trials, recent studies have demonstrated unexpected novel functions of MMPs in viral infections and autoimmune inflammatory diseases in unanticipated locations. Thus, MMPs play additional functions in inflammation than just ECM degradation. They can regulate the activity of chemokines and cytokines of the immune response by precise proteolytic processing resulting in activation or inactivation of signaling pathways. MMPs have been demonstrated to cleave multiple substrates of the central nervous systems (CNS) and contribute to promoting and dampening diseases of the CNS. Initially, believed to be solely promoting pathologies, more than 10 MMPs to date have been shown to have protective functions. Here, we present some of the beneficial and destructive roles of MMPs in CNS pathologies and discuss strategies for the use of MMP inhibitors. SN - 1420-9071 UR - https://www.unboundmedicine.com/medline/citation/31165203/Matrix_metalloproteinases_in_the_CNS:_interferons_get_nervous_ L2 - https://doi.org/10.1007/s00018-019-03171-9 DB - PRIME DP - Unbound Medicine ER -