Tags

Type your tag names separated by a space and hit enter

25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese.
Public Health Nutr. 2020 05; 23(7):1201-1207.PH

Abstract

OBJECTIVE

To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) and risk of incident diabetes in Hong Kong Chinese, after accounting for the effect of multiple bone- and mineral-related markers.

DESIGN

We conducted a retrospective study on the Hong Kong Osteoporosis Study cohort. Incident diabetes was ascertained using electronic medical records. Serum 25(OH)D was measured at baseline and its association with incident diabetes was evaluated using multivariable Cox proportional-hazard regression.

PARTICIPANTS

Individuals (n 4342) aged 20 years or above (1395 men, 2947 women; mean age 54·3 (sd 16·5) years) from the Hong Kong Osteoporosis Study, who were free of diabetes at baseline, were included.

RESULTS

During 40 124·7 person-years of follow-up (a median of 9·2 years), 443 participants developed diabetes. Mean 25(OH)D was 63·34 (sd 13·07) nmol/l. Age-, sex- and BMI-adjusted Cox proportional-hazard regression showed no significant difference in the risk of incident diabetes between the lowest and the highest quintiles of 25(OH)D. In the analysis of the interaction effect between 25(OH)D and serum Ca, the interaction term did not affect the risk of incident diabetes significantly (P = 0·694). Similarly, there was no significant interaction of different subgroups (age, sex, BMI, femoral-neck T-score, serum Ca levels) with serum 25(OH)D.

CONCLUSIONS

The present study finds that serum vitamin D level is not associated with the risk of incident diabetes in Hong Kong Chinese and this relationship is not modified by serum Ca level.

Authors+Show Affiliations

Department of Pharmacology and Pharmacy, The University of Hong Kong, Sasson Road, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China. Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.Department of Pharmacology and Pharmacy, The University of Hong Kong, Sasson Road, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.Department of Pharmacology and Pharmacy, The University of Hong Kong, Sasson Road, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China. Centre for Genomic Sciences, University of Hong Kong, Sasson Road, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31169100

Citation

Leung, Raymond Yh, et al. "25-Hydroxyvitamin D and the Risk of Incident Diabetes in Hong Kong Chinese." Public Health Nutrition, vol. 23, no. 7, 2020, pp. 1201-1207.
Leung RY, Cheung BM, Tan KC, et al. 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese. Public Health Nutr. 2020;23(7):1201-1207.
Leung, R. Y., Cheung, B. M., Tan, K. C., Kung, A. W., & Cheung, C. L. (2020). 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese. Public Health Nutrition, 23(7), 1201-1207. https://doi.org/10.1017/S1368980019000582
Leung RY, et al. 25-Hydroxyvitamin D and the Risk of Incident Diabetes in Hong Kong Chinese. Public Health Nutr. 2020;23(7):1201-1207. PubMed PMID: 31169100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese. AU - Leung,Raymond Yh, AU - Cheung,Bernard My, AU - Tan,Kathryn Cb, AU - Kung,Annie Wc, AU - Cheung,Ching-Lung, Y1 - 2019/06/06/ PY - 2019/6/7/pubmed PY - 2020/9/23/medline PY - 2019/6/7/entrez KW - Diabetes mellitus KW - Epidemiological studies KW - Serum calcium KW - Vitamin D SP - 1201 EP - 1207 JF - Public health nutrition JO - Public Health Nutr VL - 23 IS - 7 N2 - OBJECTIVE: To investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) and risk of incident diabetes in Hong Kong Chinese, after accounting for the effect of multiple bone- and mineral-related markers. DESIGN: We conducted a retrospective study on the Hong Kong Osteoporosis Study cohort. Incident diabetes was ascertained using electronic medical records. Serum 25(OH)D was measured at baseline and its association with incident diabetes was evaluated using multivariable Cox proportional-hazard regression. PARTICIPANTS: Individuals (n 4342) aged 20 years or above (1395 men, 2947 women; mean age 54·3 (sd 16·5) years) from the Hong Kong Osteoporosis Study, who were free of diabetes at baseline, were included. RESULTS: During 40 124·7 person-years of follow-up (a median of 9·2 years), 443 participants developed diabetes. Mean 25(OH)D was 63·34 (sd 13·07) nmol/l. Age-, sex- and BMI-adjusted Cox proportional-hazard regression showed no significant difference in the risk of incident diabetes between the lowest and the highest quintiles of 25(OH)D. In the analysis of the interaction effect between 25(OH)D and serum Ca, the interaction term did not affect the risk of incident diabetes significantly (P = 0·694). Similarly, there was no significant interaction of different subgroups (age, sex, BMI, femoral-neck T-score, serum Ca levels) with serum 25(OH)D. CONCLUSIONS: The present study finds that serum vitamin D level is not associated with the risk of incident diabetes in Hong Kong Chinese and this relationship is not modified by serum Ca level. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/31169100/25_Hydroxyvitamin_D_and_the_risk_of_incident_diabetes_in_Hong_Kong_Chinese_ L2 - https://www.cambridge.org/core/product/identifier/S1368980019000582/type/journal_article DB - PRIME DP - Unbound Medicine ER -