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Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat.
J Chem Neuroanat. 2019 10; 100:101654.JC

Abstract

Aluminum (Al) among the abundant metals on the earth crust, is able to cross the biological barriers via the gastrointestinal and lung tissues. Once in the body, this heavy metal accumulates in different organs, especially the central nervous system. Though its influence is evidently shown in the substantia nigra of Parkinson's disease patients and other brain areas in other neurodegenerative diseases, few studies have demonstrated that Al could trigger profound changes in neurotransmission systems including the dopaminergic (DAergic) system. A variety of medicinal plants may be prescribed in such contamination, including some culinary spices such as Curcumin (Cur). Several studies have proven Cur to exhibit a wide variety of biological and pharmacological activities, especially its antioxidant potential. Using the immunohistochemistry, of tyrosine hydroxylase (TH), in the midbrain substantia nigra pars compact (SNc) and the ventral tegmental area (VTA) and the open field test, we examined the DAergic system together with the locomotor behavior respectively in rats exposed chronically to Al (0,3%) in drinking water during 4 months since the intra-uterine age, as well as the neuroprotective effect of the concomitant administration of Cur I (30 mg/kg B.W) of chronic Al exposed rats. Our results have shown a significant decrease of TH immureactivity in both SNc and VTA associated to a loss of the number of crossed boxes, leading to a difficient locomotor performance in the Al group while Cur I prevents such TH immunoreactivity impairment and maintains a higher locomotor activity in the Al-CurI group. Our findings lead to suppose a powerful and obvious neuroprotective potential of CurI against Al-induced neurotoxicity of the DAergic system involved in the control of the locomotor behavior.

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Authors+Show Affiliations

Laabbar W
Equip Neurosciences, Pharmacology and Environment, Cadi Ayyad University, Faculty of Sciences Semlalia, B.P. 2390, Marrakesh, Morocco.
Elgot A
Equip Neurosciences, Pharmacology and Environment, Cadi Ayyad University, Faculty of Sciences Semlalia, B.P. 2390, Marrakesh, Morocco; Laboratoire des Sciences et Technologies de la Santé, Unité des Sciences biomédicales, Institut Supérieur des Sciences de la santé, Université Hassan I, Settat, Morocco.
Elhiba O
Equip Neurosciences, Pharmacology and Environment, Cadi Ayyad University, Faculty of Sciences Semlalia, B.P. 2390, Marrakesh, Morocco; Nutrition and Food Sciences laboratory, Nutritional Physiopathologies Team, Faculty of Sciences, Chouaib Doukkali University El Jadida,Route Ben Maachou, B.P. 20, Avenue des Facultés, El Jadida, Morocco.
Gamrani H
Equip Neurosciences, Pharmacology and Environment, Cadi Ayyad University, Faculty of Sciences Semlalia, B.P. 2390, Marrakesh, Morocco. Electronic address: gamrani@uca.ac.ma.

MeSH

AluminumAnimalsCurcuminDopaminergic NeuronsLocomotionMesencephalonNeuroprotective AgentsNeurotoxicity SyndromesRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31170442

Citation

Laabbar, Wafaa, et al. "Curcumin Prevents the Midbrain Dopaminergic Innervations and Locomotor Performance Deficiencies Resulting From Chronic Aluminum Exposure in Rat." Journal of Chemical Neuroanatomy, vol. 100, 2019, p. 101654.
Laabbar W, Elgot A, Elhiba O, et al. Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. J Chem Neuroanat. 2019;100:101654.
Laabbar, W., Elgot, A., Elhiba, O., & Gamrani, H. (2019). Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. Journal of Chemical Neuroanatomy, 100, 101654. https://doi.org/10.1016/j.jchemneu.2019.101654
Laabbar W, et al. Curcumin Prevents the Midbrain Dopaminergic Innervations and Locomotor Performance Deficiencies Resulting From Chronic Aluminum Exposure in Rat. J Chem Neuroanat. 2019;100:101654. PubMed PMID: 31170442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. AU - Laabbar,Wafaa, AU - Elgot,Abdeljalil, AU - Elhiba,Omar, AU - Gamrani,Halima, Y1 - 2019/06/04/ PY - 2019/02/16/received PY - 2019/05/06/revised PY - 2019/05/24/accepted PY - 2019/6/7/pubmed PY - 2020/9/12/medline PY - 2019/6/7/entrez KW - Aluminum KW - Chronic intoxication KW - Curcumin KW - Locomotor activity KW - Parkinson’s disease KW - Substantia nigra KW - Tyrosine hydroxylase KW - Ventral tegmental area KW - Wistar Rats SP - 101654 EP - 101654 JF - Journal of chemical neuroanatomy JO - J Chem Neuroanat VL - 100 N2 - Aluminum (Al) among the abundant metals on the earth crust, is able to cross the biological barriers via the gastrointestinal and lung tissues. Once in the body, this heavy metal accumulates in different organs, especially the central nervous system. Though its influence is evidently shown in the substantia nigra of Parkinson's disease patients and other brain areas in other neurodegenerative diseases, few studies have demonstrated that Al could trigger profound changes in neurotransmission systems including the dopaminergic (DAergic) system. A variety of medicinal plants may be prescribed in such contamination, including some culinary spices such as Curcumin (Cur). Several studies have proven Cur to exhibit a wide variety of biological and pharmacological activities, especially its antioxidant potential. Using the immunohistochemistry, of tyrosine hydroxylase (TH), in the midbrain substantia nigra pars compact (SNc) and the ventral tegmental area (VTA) and the open field test, we examined the DAergic system together with the locomotor behavior respectively in rats exposed chronically to Al (0,3%) in drinking water during 4 months since the intra-uterine age, as well as the neuroprotective effect of the concomitant administration of Cur I (30 mg/kg B.W) of chronic Al exposed rats. Our results have shown a significant decrease of TH immureactivity in both SNc and VTA associated to a loss of the number of crossed boxes, leading to a difficient locomotor performance in the Al group while Cur I prevents such TH immunoreactivity impairment and maintains a higher locomotor activity in the Al-CurI group. Our findings lead to suppose a powerful and obvious neuroprotective potential of CurI against Al-induced neurotoxicity of the DAergic system involved in the control of the locomotor behavior. SN - 1873-6300 UR - https://www.unboundmedicine.com/medline/citation/31170442/Curcumin_prevents_the_midbrain_dopaminergic_innervations_and_locomotor_performance_deficiencies_resulting_from_chronic_aluminum_exposure_in_rat_ DB - PRIME DP - Unbound Medicine ER -