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Hereditary Cancer Syndromes-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes.
Mayo Clin Proc. 2019 06; 94(6):1099-1116.MC

Abstract

Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ. Electronic address: Samadder.jewel@mayo.edu.Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ.Division of Medical Oncology, Mayo Clinic, Rochester, MN.Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.Department of Clinical Genomics and Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31171120

Citation

Samadder, N Jewel, et al. "Hereditary Cancer Syndromes-A Primer On Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes." Mayo Clinic Proceedings, vol. 94, no. 6, 2019, pp. 1099-1116.
Samadder NJ, Baffy N, Giridhar KV, et al. Hereditary Cancer Syndromes-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes. Mayo Clin Proc. 2019;94(6):1099-1116.
Samadder, N. J., Baffy, N., Giridhar, K. V., Couch, F. J., & Riegert-Johnson, D. (2019). Hereditary Cancer Syndromes-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes. Mayo Clinic Proceedings, 94(6), 1099-1116. https://doi.org/10.1016/j.mayocp.2019.01.042
Samadder NJ, et al. Hereditary Cancer Syndromes-A Primer On Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes. Mayo Clin Proc. 2019;94(6):1099-1116. PubMed PMID: 31171120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary Cancer Syndromes-A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes. AU - Samadder,N Jewel, AU - Baffy,Noemi, AU - Giridhar,Karthik V, AU - Couch,Fergus J, AU - Riegert-Johnson,Douglas, PY - 2017/11/07/received PY - 2019/01/15/accepted PY - 2019/6/8/entrez PY - 2019/6/7/pubmed PY - 2020/1/16/medline SP - 1099 EP - 1116 JF - Mayo Clinic proceedings JO - Mayo Clin Proc VL - 94 IS - 6 N2 - Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/31171120/Hereditary_Cancer_Syndromes_A_Primer_on_Diagnosis_and_Management_Part_2:_Gastrointestinal_Cancer_Syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(19)30214-9 DB - PRIME DP - Unbound Medicine ER -