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Association of maternal folate intake during pregnancy with infant asthma risk.
Sci Rep. 2019 06 06; 9(1):8347.SR

Abstract

Several studies assessed the association of maternal folate intake with infant asthma risk, but the findings are controversial. We performed a meta-analysis to clarify the association between maternal folate intake and infant asthma risk. PubMed and SCOPUS databases were searched for related studies published until August 2018. Fixed-effects models were applied to pool relative risks (RRs) and their corresponding 95% confidence intervals (CIs) due to the low heterogeneity. We also adopted generalized least-squares trend (GLST) estimation for the dose-response analysis. In our study, a total of 10 studies with maternal folate intake and 5 studies with blood folate concentration were included. We found that maternal folate intake during pregnancy was significantly related to the risk of infant asthma (RR = 1.11; 95% CI = 1.06-1.17). Similar results were found for geographic region from Europe (RR = 1.08; 95% CI = 1.01-1.16) and North America (RR = 1.20; 95% CI = 1.11-1.30) in subgroup analyses. Meanwhile, the dose-response analysis showed a linear relationship between maternal folic acid intake during pregnancy and infant asthma risk. This meta-analysis indicates that maternal folate intake during pregnancy could increase infant asthma risk. Therefore, the adverse effect of folic acid on infant asthma should not be ignored when it is supplemented during pregnancy to prevent birth defects.

Authors+Show Affiliations

The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. Department of Urology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, 211166, China.Department of Urology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.The First People's Hospital of Zhangjiagang city, The Zhangjiagang Affiliated Hospital of Soochow University, Suzhou, 215600, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.Department of Urology, Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. kaipengxie@njmu.edu.cn.The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, 210004, China. wujiangping@njmu.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31171831

Citation

Li, Weijian, et al. "Association of Maternal Folate Intake During Pregnancy With Infant Asthma Risk." Scientific Reports, vol. 9, no. 1, 2019, p. 8347.
Li W, Xu B, Cao Y, et al. Association of maternal folate intake during pregnancy with infant asthma risk. Sci Rep. 2019;9(1):8347.
Li, W., Xu, B., Cao, Y., Shao, Y., Wu, W., Zhou, J., Tan, X., Wu, X., Kong, J., Hu, C., Xie, K., & Wu, J. (2019). Association of maternal folate intake during pregnancy with infant asthma risk. Scientific Reports, 9(1), 8347. https://doi.org/10.1038/s41598-019-44794-z
Li W, et al. Association of Maternal Folate Intake During Pregnancy With Infant Asthma Risk. Sci Rep. 2019 06 6;9(1):8347. PubMed PMID: 31171831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of maternal folate intake during pregnancy with infant asthma risk. AU - Li,Weijian, AU - Xu,Bo, AU - Cao,Yuepeng, AU - Shao,Yang, AU - Wu,Wanke, AU - Zhou,Jun, AU - Tan,Xiaofang, AU - Wu,Xiaoli, AU - Kong,Jing, AU - Hu,Chen, AU - Xie,Kaipeng, AU - Wu,Jiangping, Y1 - 2019/06/06/ PY - 2018/11/07/received PY - 2019/05/24/accepted PY - 2019/6/8/entrez PY - 2019/6/7/pubmed PY - 2020/10/31/medline SP - 8347 EP - 8347 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - Several studies assessed the association of maternal folate intake with infant asthma risk, but the findings are controversial. We performed a meta-analysis to clarify the association between maternal folate intake and infant asthma risk. PubMed and SCOPUS databases were searched for related studies published until August 2018. Fixed-effects models were applied to pool relative risks (RRs) and their corresponding 95% confidence intervals (CIs) due to the low heterogeneity. We also adopted generalized least-squares trend (GLST) estimation for the dose-response analysis. In our study, a total of 10 studies with maternal folate intake and 5 studies with blood folate concentration were included. We found that maternal folate intake during pregnancy was significantly related to the risk of infant asthma (RR = 1.11; 95% CI = 1.06-1.17). Similar results were found for geographic region from Europe (RR = 1.08; 95% CI = 1.01-1.16) and North America (RR = 1.20; 95% CI = 1.11-1.30) in subgroup analyses. Meanwhile, the dose-response analysis showed a linear relationship between maternal folic acid intake during pregnancy and infant asthma risk. This meta-analysis indicates that maternal folate intake during pregnancy could increase infant asthma risk. Therefore, the adverse effect of folic acid on infant asthma should not be ignored when it is supplemented during pregnancy to prevent birth defects. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31171831/Association_of_maternal_folate_intake_during_pregnancy_with_infant_asthma_risk_ L2 - https://doi.org/10.1038/s41598-019-44794-z DB - PRIME DP - Unbound Medicine ER -