Tags

Type your tag names separated by a space and hit enter

Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System.
Transl Vis Sci Technol 2019; 8(3):31TV

Abstract

Purpose

To characterize histologic changes in the optic nerve and the retina of an end-stage retinitis pigmentosa (RP) patient after long-term implantation with the Argus II retinal prosthesis system.

Methods

Serial cross sections from the patient's both eyes were collected postmortem 6 years after implantation. Optic nerve from both eyes were morphometrically analyzed and compared. Retina underneath and outside the array was analyzed and compared with corresponding regions in the fellow eye.

Results

Although the optic nerve of the implant eye demonstrated significantly more overall atrophy than the fellow eye (P < 0.01), the temporal quadrant that retinotopically corresponded to the location of the array did not show additional damage. The total neuron count of the macular area was not significantly different between the two eyes, but the tack locations and their adjacent areas showed significantly fewer neurons than other perimacular areas. There was an increased expression of glial fibrillary acidic protein (GFAP) throughout the retina in the implant eye versus the fellow eye, but there was no significant difference in the cellular retinaldehyde-binding protein (CRALBP) expression. Except for the revision tack site, no significant increase of inflammatory reaction was detected in the implant eye.

Conclusion

Long-term implantation and electrical stimulation with an Argus II retinal prosthesis system did not result in significant tissue damage that could be detected by a morphometric analysis.

Translational Relevance

This study supports the long-term safety of the Argus II device and encourages further development of bioelectronics devices at the retina-machine interface.

Authors+Show Affiliations

Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, USA. Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China. School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, USA.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo, São Paulo, Brazil.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.Retina Foundation of the Southwest, Dallas, TX, USA.Texas Retina Associates, Dallas, TX, USA.Second Sight Medical Products, Inc., Sylmar, CA, USA.Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA. USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31171998

Citation

Lin, Tai-Chi, et al. "Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System." Translational Vision Science & Technology, vol. 8, no. 3, 2019, p. 31.
Lin TC, Wang LC, Yue L, et al. Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System. Transl Vis Sci Technol. 2019;8(3):31.
Lin, T. C., Wang, L. C., Yue, L., Zhang, Y., Falabella, P., Zhu, D., ... Humayun, M. S. (2019). Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System. Translational Vision Science & Technology, 8(3), p. 31. doi:10.1167/tvst.8.3.31.
Lin TC, et al. Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System. Transl Vis Sci Technol. 2019;8(3):31. PubMed PMID: 31171998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System. AU - Lin,Tai-Chi, AU - Wang,Lei-Chi, AU - Yue,Lan, AU - Zhang,Yi, AU - Falabella,Paulo, AU - Zhu,Danhong, AU - Hinton,David R, AU - Rao,Narsing A, AU - Birch,David G, AU - Spencer,Rand, AU - Dorn,Jessy D, AU - Humayun,Mark S, Y1 - 2019/05/30/ PY - 2018/12/03/received PY - 2019/04/01/accepted PY - 2019/6/8/entrez PY - 2019/6/7/pubmed PY - 2019/6/7/medline KW - histopathology KW - retinal prosthesis KW - retinitis pigmentosa SP - 31 EP - 31 JF - Translational vision science & technology JO - Transl Vis Sci Technol VL - 8 IS - 3 N2 - Purpose: To characterize histologic changes in the optic nerve and the retina of an end-stage retinitis pigmentosa (RP) patient after long-term implantation with the Argus II retinal prosthesis system. Methods: Serial cross sections from the patient's both eyes were collected postmortem 6 years after implantation. Optic nerve from both eyes were morphometrically analyzed and compared. Retina underneath and outside the array was analyzed and compared with corresponding regions in the fellow eye. Results: Although the optic nerve of the implant eye demonstrated significantly more overall atrophy than the fellow eye (P < 0.01), the temporal quadrant that retinotopically corresponded to the location of the array did not show additional damage. The total neuron count of the macular area was not significantly different between the two eyes, but the tack locations and their adjacent areas showed significantly fewer neurons than other perimacular areas. There was an increased expression of glial fibrillary acidic protein (GFAP) throughout the retina in the implant eye versus the fellow eye, but there was no significant difference in the cellular retinaldehyde-binding protein (CRALBP) expression. Except for the revision tack site, no significant increase of inflammatory reaction was detected in the implant eye. Conclusion: Long-term implantation and electrical stimulation with an Argus II retinal prosthesis system did not result in significant tissue damage that could be detected by a morphometric analysis. Translational Relevance: This study supports the long-term safety of the Argus II device and encourages further development of bioelectronics devices at the retina-machine interface. SN - 2164-2591 UR - https://www.unboundmedicine.com/medline/citation/31171998/Histopathologic_Assessment_of_Optic_Nerves_and_Retina_From_a_Patient_With_Chronically_Implanted_Argus_II_Retinal_Prosthesis_System_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31171998/ DB - PRIME DP - Unbound Medicine ER -