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Isolated invasive ductal carcinoma of the nipple-areolar complex: A rare occurrence yet to be reported in current literature.
Breast J 2019; 25(4):706-708BJ

Abstract

Invasive ductal carcinoma of the nipple-areolar complex is exceedingly rare. Patients who present with bloody nipple discharge with or without the presence of Paget's disease constitute one-third of all symptomatic in situ patients. Only rarely does an invasive cancer cause nipple discharge in the absence of a clinical mass. Even more obscure is the case of the invasive cancer involving solely the nipple-areolar complex. Sir James Paget first described 'an eczematous change in the skin of the nipple preceding an underlying mammary cancer' in 1874, which is now known as Paget's disease, considered to be ductal carcinoma in situ of the nipple-areolar region. There are two competing theories as to the pathogenesis of Paget's disease of the breast-one suggests that Pagetoid cells are keratinocytes that have undergone malignant transformation. According to this theory, Paget's disease of the breast represents an in situ carcinoma of the skin-and that overlying skin changes and underlying malignancy are discontinuous. The second theory suggests that cells migrate along basement membranes and enter the epidermis and dermis of the nipple-areola complex. Pagetoid cells and underlying carcinomas demonstrate similar immunohistochemical staining patterns.

Authors+Show Affiliations

Department of General Surgery, Singapore General Hospital, Singapore, Singapore.Department of Surgical Oncology, National Cancer Centre, Singapore, Singapore.Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31172621

Citation

Hamzah, Julie Liana, et al. "Isolated Invasive Ductal Carcinoma of the Nipple-areolar Complex: a Rare Occurrence yet to Be Reported in Current Literature." The Breast Journal, vol. 25, no. 4, 2019, pp. 706-708.
Hamzah JL, Ong KW, Tan BY. Isolated invasive ductal carcinoma of the nipple-areolar complex: A rare occurrence yet to be reported in current literature. Breast J. 2019;25(4):706-708.
Hamzah, J. L., Ong, K. W., & Tan, B. Y. (2019). Isolated invasive ductal carcinoma of the nipple-areolar complex: A rare occurrence yet to be reported in current literature. The Breast Journal, 25(4), pp. 706-708. doi:10.1111/tbj.13308.
Hamzah JL, Ong KW, Tan BY. Isolated Invasive Ductal Carcinoma of the Nipple-areolar Complex: a Rare Occurrence yet to Be Reported in Current Literature. Breast J. 2019;25(4):706-708. PubMed PMID: 31172621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolated invasive ductal carcinoma of the nipple-areolar complex: A rare occurrence yet to be reported in current literature. AU - Hamzah,Julie Liana, AU - Ong,Kong Wee, AU - Tan,Benjamin Yongcheng, Y1 - 2019/06/06/ PY - 2018/10/19/received PY - 2018/10/24/accepted PY - 2019/6/7/pubmed PY - 2019/6/7/medline PY - 2019/6/8/entrez KW - Paget's disease KW - invasive ductal carcinoma KW - invasive ductal carcinoma of the nipple SP - 706 EP - 708 JF - The breast journal JO - Breast J VL - 25 IS - 4 N2 - Invasive ductal carcinoma of the nipple-areolar complex is exceedingly rare. Patients who present with bloody nipple discharge with or without the presence of Paget's disease constitute one-third of all symptomatic in situ patients. Only rarely does an invasive cancer cause nipple discharge in the absence of a clinical mass. Even more obscure is the case of the invasive cancer involving solely the nipple-areolar complex. Sir James Paget first described 'an eczematous change in the skin of the nipple preceding an underlying mammary cancer' in 1874, which is now known as Paget's disease, considered to be ductal carcinoma in situ of the nipple-areolar region. There are two competing theories as to the pathogenesis of Paget's disease of the breast-one suggests that Pagetoid cells are keratinocytes that have undergone malignant transformation. According to this theory, Paget's disease of the breast represents an in situ carcinoma of the skin-and that overlying skin changes and underlying malignancy are discontinuous. The second theory suggests that cells migrate along basement membranes and enter the epidermis and dermis of the nipple-areola complex. Pagetoid cells and underlying carcinomas demonstrate similar immunohistochemical staining patterns. SN - 1524-4741 UR - https://www.unboundmedicine.com/medline/citation/31172621/Isolated_invasive_ductal_carcinoma_of_the_nipple-areolar_complex:_A_rare_occurrence_yet_to_be_reported_in_current_literature L2 - https://doi.org/10.1111/tbj.13308 DB - PRIME DP - Unbound Medicine ER -