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Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017.
Anaerobe. 2019 Dec; 60:102050.A

Abstract

PCR ribotyping and antimicrobial susceptibility testing were used to characterize 940 Clostridioides (Clostridium) difficile isolates collected from 26 U S. hospitals over three time periods from 2011 to 2017. The proportion of ribotype (RT) 027 isolated during the three surveys decreased significantly over time from 31% in 2011-2012, to 22% in 2013-2014, and to 14% in 2015-2017 (p < 0.001 and p = 0.010, respectively), while we observed an increase in prevalence of RT106, that rose from 7% in our first survey to 19% of isolates in our last survey (p < 0.001). In addition, both RT056 and RT002 rose from 3% to 10% (p < 0.001). The proportions of all other ribotypes remained steady over time, and RT014/020 was the third most common strain type in our convenience sample in the final survey. Overall, resistance to moxifloxacin, rifampin, and vancomycin decreased during our studies, mainly due to the decline in RT027 isolates. A decrease in moxifloxacin resistance and an increase in tetracycline resistance were found among RT027 strains isolated in the last survey. Although the proportion of RT027 isolates declined, multidrug resistance among this ribotype continues to be common.

Authors+Show Affiliations

Cepheid, Sunnyvale, CA, United States. Electronic address: isabella.tickler@cepheid.com.Creighton University School of Medicine, Omaha, NE, United States.Creighton University School of Medicine, Omaha, NE, United States.University of Washington School of Medicine, Seattle, WA, United States.Cepheid, Sunnyvale, CA, United States.No affiliation info available

Pub Type(s)

Historical Article
Journal Article

Language

eng

PubMed ID

31173889

Citation

Tickler, Isabella A., et al. "Changes in Molecular Epidemiology and Antimicrobial Resistance Profiles of Clostridioides (Clostridium) Difficile Strains in the United States Between 2011 and 2017." Anaerobe, vol. 60, 2019, p. 102050.
Tickler IA, Obradovich AE, Goering RV, et al. Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017. Anaerobe. 2019;60:102050.
Tickler, I. A., Obradovich, A. E., Goering, R. V., Fang, F. C., & Tenover, F. C. (2019). Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017. Anaerobe, 60, 102050. https://doi.org/10.1016/j.anaerobe.2019.06.003
Tickler IA, et al. Changes in Molecular Epidemiology and Antimicrobial Resistance Profiles of Clostridioides (Clostridium) Difficile Strains in the United States Between 2011 and 2017. Anaerobe. 2019;60:102050. PubMed PMID: 31173889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in molecular epidemiology and antimicrobial resistance profiles of Clostridioides (Clostridium) difficile strains in the United States between 2011 and 2017. AU - Tickler,Isabella A, AU - Obradovich,Anne E, AU - Goering,Richard V, AU - Fang,Ferric C, AU - Tenover,Fred C, AU - ,, Y1 - 2019/06/04/ PY - 2019/02/02/received PY - 2019/05/13/revised PY - 2019/06/03/accepted PY - 2019/6/8/pubmed PY - 2020/4/21/medline PY - 2019/6/8/entrez KW - Antimicrobial susceptibility KW - Clostridioides difficile KW - Clostridium difficile KW - PCR ribotypes SP - 102050 EP - 102050 JF - Anaerobe JO - Anaerobe VL - 60 N2 - PCR ribotyping and antimicrobial susceptibility testing were used to characterize 940 Clostridioides (Clostridium) difficile isolates collected from 26 U S. hospitals over three time periods from 2011 to 2017. The proportion of ribotype (RT) 027 isolated during the three surveys decreased significantly over time from 31% in 2011-2012, to 22% in 2013-2014, and to 14% in 2015-2017 (p < 0.001 and p = 0.010, respectively), while we observed an increase in prevalence of RT106, that rose from 7% in our first survey to 19% of isolates in our last survey (p < 0.001). In addition, both RT056 and RT002 rose from 3% to 10% (p < 0.001). The proportions of all other ribotypes remained steady over time, and RT014/020 was the third most common strain type in our convenience sample in the final survey. Overall, resistance to moxifloxacin, rifampin, and vancomycin decreased during our studies, mainly due to the decline in RT027 isolates. A decrease in moxifloxacin resistance and an increase in tetracycline resistance were found among RT027 strains isolated in the last survey. Although the proportion of RT027 isolates declined, multidrug resistance among this ribotype continues to be common. SN - 1095-8274 UR - https://www.unboundmedicine.com/medline/citation/31173889/Changes_in_molecular_epidemiology_and_antimicrobial_resistance_profiles_of_Clostridioides__Clostridium__difficile_strains_in_the_United_States_between_2011_and_2017_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1075-9964(19)30100-3 DB - PRIME DP - Unbound Medicine ER -