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Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research.
BMC Complement Altern Med 2019; 19(1):121BC

Abstract

BACKGROUND

Myeloproliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn't been demonstrated in MPNs. The purpose of this study was to: (1) explore the limited efficacy (does the program show promise of success) of a 12-week online yoga intervention among MPN patients on symptom burden and quality of life and (2) determine feasibility (practicality: to what extent a measure can be carried out) of remotely collecting inflammatory biomarkers.

METHODS

Patients were recruited nationally and randomized to online yoga (60 min/week of yoga) or wait-list control (asked to maintain normal activity). Weekly yoga minutes were collected with Clicky (online web analytics tool) and self-report. Those in online yoga completed a blood draw at baseline and week 12 to assess inflammation (interleukin-6, tumor necrosis factor-alpha [TNF-α]). All participants completed questionnaires assessing depression, anxiety, fatigue, pain, sleep disturbance, sexual function, total symptom burden, global health, and quality of life at baseline, week seven, 12, and 16. Change from baseline at each time point was computed by group and effect sizes were calculated. Pre-post intervention change in inflammation for the yoga group was compared by t-test.

RESULTS

Sixty-two MPN patients enrolled and 48 completed the intervention (online yoga = 27; control group = 21). Yoga participation averaged 40.8 min/week via Clicky and 56.1 min/week via self-report. Small/moderate effect sizes were generated from the yoga intervention for sleep disturbance (d = - 0.26 to - 0.61), pain intensity (d = - 0.34 to - 0.51), anxiety (d = - 0.27 to - 0.37), and depression (d = - 0.53 to - 0.78). A total of 92.6 and 70.4% of online yoga participants completed the blood draw at baseline and week 12, respectively, and there was a decrease in TNF-α from baseline to week 12 (- 1.3 ± 1.5 pg/ml).

CONCLUSIONS

Online yoga demonstrated small effects on sleep, pain, and anxiety as well as a moderate effect on depression. Remote blood draw procedures are feasible and the effect size of the intervention on TNF-α was large. Future fully powered randomized controlled trials are needed to test for efficacy.

TRIAL REGISTRATION

This trial was retrospectively registered with clinicaltrials.gov (ID: NCT03503838) on 4/19/2018.

Authors+Show Affiliations

Exercise Science and Health Promotion, Arizona State University, 500 North 3rd Street Phoenix, Tempe, AZ 85004, USA. Jennifer.huberty@asu.edu.Mays Cancer Center, University of Texas San Antonio MD Anderson, 7979 Wurzbach Road, San Antonio, TX, 78229, USA.Division of Biostatistics, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.Division of Biostatistics, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.College of Nursing and Health Innovation, Arizona State University, 550 North 3rd Street, Phoenix, AZ, 85004, USA.University of Arizona, 1501 North Campbell Avenue, Tucson, AZ, 85724, USA.Mays Cancer Center, University of Texas San Antonio MD Anderson, 7979 Wurzbach Road, San Antonio, TX, 78229, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31174535

Citation

Huberty, Jennifer, et al. "Online Yoga in Myeloproliferative Neoplasm Patients: Results of a Randomized Pilot Trial to Inform Future Research." BMC Complementary and Alternative Medicine, vol. 19, no. 1, 2019, p. 121.
Huberty J, Eckert R, Dueck A, et al. Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research. BMC Complement Altern Med. 2019;19(1):121.
Huberty, J., Eckert, R., Dueck, A., Kosiorek, H., Larkey, L., Gowin, K., & Mesa, R. (2019). Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research. BMC Complementary and Alternative Medicine, 19(1), p. 121. doi:10.1186/s12906-019-2530-8.
Huberty J, et al. Online Yoga in Myeloproliferative Neoplasm Patients: Results of a Randomized Pilot Trial to Inform Future Research. BMC Complement Altern Med. 2019 Jun 7;19(1):121. PubMed PMID: 31174535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Online yoga in myeloproliferative neoplasm patients: results of a randomized pilot trial to inform future research. AU - Huberty,Jennifer, AU - Eckert,Ryan, AU - Dueck,Amylou, AU - Kosiorek,Heidi, AU - Larkey,Linda, AU - Gowin,Krisstina, AU - Mesa,Ruben, Y1 - 2019/06/07/ PY - 2018/04/19/received PY - 2019/05/29/accepted PY - 2019/6/9/entrez PY - 2019/6/9/pubmed PY - 2019/8/20/medline KW - Cancer KW - Complementary KW - Mindfulness KW - Neoplasm KW - Physical activity SP - 121 EP - 121 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 19 IS - 1 N2 - BACKGROUND: Myeloproliferative neoplasm (MPN) patients suffer from significant symptoms, inflammation and reduced quality of life. Yoga improves these outcomes in other cancers, but this hasn't been demonstrated in MPNs. The purpose of this study was to: (1) explore the limited efficacy (does the program show promise of success) of a 12-week online yoga intervention among MPN patients on symptom burden and quality of life and (2) determine feasibility (practicality: to what extent a measure can be carried out) of remotely collecting inflammatory biomarkers. METHODS: Patients were recruited nationally and randomized to online yoga (60 min/week of yoga) or wait-list control (asked to maintain normal activity). Weekly yoga minutes were collected with Clicky (online web analytics tool) and self-report. Those in online yoga completed a blood draw at baseline and week 12 to assess inflammation (interleukin-6, tumor necrosis factor-alpha [TNF-α]). All participants completed questionnaires assessing depression, anxiety, fatigue, pain, sleep disturbance, sexual function, total symptom burden, global health, and quality of life at baseline, week seven, 12, and 16. Change from baseline at each time point was computed by group and effect sizes were calculated. Pre-post intervention change in inflammation for the yoga group was compared by t-test. RESULTS: Sixty-two MPN patients enrolled and 48 completed the intervention (online yoga = 27; control group = 21). Yoga participation averaged 40.8 min/week via Clicky and 56.1 min/week via self-report. Small/moderate effect sizes were generated from the yoga intervention for sleep disturbance (d = - 0.26 to - 0.61), pain intensity (d = - 0.34 to - 0.51), anxiety (d = - 0.27 to - 0.37), and depression (d = - 0.53 to - 0.78). A total of 92.6 and 70.4% of online yoga participants completed the blood draw at baseline and week 12, respectively, and there was a decrease in TNF-α from baseline to week 12 (- 1.3 ± 1.5 pg/ml). CONCLUSIONS: Online yoga demonstrated small effects on sleep, pain, and anxiety as well as a moderate effect on depression. Remote blood draw procedures are feasible and the effect size of the intervention on TNF-α was large. Future fully powered randomized controlled trials are needed to test for efficacy. TRIAL REGISTRATION: This trial was retrospectively registered with clinicaltrials.gov (ID: NCT03503838) on 4/19/2018. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/31174535/Online_yoga_in_myeloproliferative_neoplasm_patients:_results_of_a_randomized_pilot_trial_to_inform_future_research_ L2 - https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-019-2530-8 DB - PRIME DP - Unbound Medicine ER -