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Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants.
Ophthalmol Retina. 2019 06; 3(6):489-499.OR

Abstract

PURPOSE

Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared.

DESIGN

Cross-sectional study.

PARTICIPANTS

Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled.

METHODS

Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination.

MAIN OUTCOME MEASURES

Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic Retinopathy Study 6-mm circle, 3-mm circle, and 3-mm ring were compared between groups. Foveal avascular zone (FAZ) area, central subfield thickness (CST), macular ganglion cell-inner plexiform layer (GC-IPL) thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness were also compared.

RESULTS

Alzheimer's participants showed significantly decreased SCP VD and PD in the 3-mm ring (P = 0.001 and P = 0.002, respectively) and 3-mm circle (P = 0.003 and P = 0.004, respectively) and decreased SCP VD in the 6-mm circle (P = 0.047) compared with MCI and significantly decreased SCP VD and PD in the 3-mm ring (P = 0.008 and P = 0.004, respectively) and 3-mm circle (P = 0.015 and P = 0.009, respectively) and SCP PD in the 6-mm circle (P = 0.033) when compared with cognitively intact controls. There was no difference in SCP VD or PD between MCI and controls (P > 0.05). FAZ area and CST did not differ significantly between groups (P > 0.05). Alzheimer's participants showed significantly decreased GC-IPL thickness over the inferior (P = 0.032) and inferonasal (P = 0.025) sectors compared with MCI and significantly decreased GC-IPL thickness over the entire (P = 0.012), superonasal (P = 0.041), inferior (P = 0.004), and inferonasal (P = 0.006) sectors compared to controls. MCI participants showed significantly decreased temporal RNFL thickness (P = 0.04) compared with controls.

CONCLUSIONS

Alzheimer's participants showed significantly reduced macular VD, PD, and GC-IPL thickness compared with MCI and controls. Changes in the retinal microvasculature may mirror small vessel cerebrovascular changes in AD.

Authors+Show Affiliations

Department of Ophthalmology, Duke University, Durham, North Carolina.Department of Ophthalmology, Duke University, Durham, North Carolina.Department of Ophthalmology, Duke University, Durham, North Carolina.Department of Ophthalmology, Duke University, Durham, North Carolina.Department of Neurology, Duke University, Durham, North Carolina.Department of Neurology, Duke University, Durham, North Carolina.Department of Ophthalmology, Duke University, Durham, North Carolina. Electronic address: sharon.fekrat@duke.edu.

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31174670

Citation

Yoon, Stephen P., et al. "Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared With Control Participants." Ophthalmology. Retina, vol. 3, no. 6, 2019, pp. 489-499.
Yoon SP, Grewal DS, Thompson AC, et al. Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants. Ophthalmol Retina. 2019;3(6):489-499.
Yoon, S. P., Grewal, D. S., Thompson, A. C., Polascik, B. W., Dunn, C., Burke, J. R., & Fekrat, S. (2019). Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants. Ophthalmology. Retina, 3(6), 489-499. https://doi.org/10.1016/j.oret.2019.02.002
Yoon SP, et al. Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared With Control Participants. Ophthalmol Retina. 2019;3(6):489-499. PubMed PMID: 31174670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants. AU - Yoon,Stephen P, AU - Grewal,Dilraj S, AU - Thompson,Atalie C, AU - Polascik,Bryce W, AU - Dunn,Cynthia, AU - Burke,James R, AU - Fekrat,Sharon, Y1 - 2019/03/11/ PY - 2018/09/30/received PY - 2018/12/30/revised PY - 2019/02/11/accepted PY - 2019/6/9/entrez PY - 2019/6/9/pubmed PY - 2020/1/23/medline SP - 489 EP - 499 JF - Ophthalmology. Retina JO - Ophthalmol Retina VL - 3 IS - 6 N2 - PURPOSE: Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared. DESIGN: Cross-sectional study. PARTICIPANTS: Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled. METHODS: Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination. MAIN OUTCOME MEASURES: Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic Retinopathy Study 6-mm circle, 3-mm circle, and 3-mm ring were compared between groups. Foveal avascular zone (FAZ) area, central subfield thickness (CST), macular ganglion cell-inner plexiform layer (GC-IPL) thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness were also compared. RESULTS: Alzheimer's participants showed significantly decreased SCP VD and PD in the 3-mm ring (P = 0.001 and P = 0.002, respectively) and 3-mm circle (P = 0.003 and P = 0.004, respectively) and decreased SCP VD in the 6-mm circle (P = 0.047) compared with MCI and significantly decreased SCP VD and PD in the 3-mm ring (P = 0.008 and P = 0.004, respectively) and 3-mm circle (P = 0.015 and P = 0.009, respectively) and SCP PD in the 6-mm circle (P = 0.033) when compared with cognitively intact controls. There was no difference in SCP VD or PD between MCI and controls (P > 0.05). FAZ area and CST did not differ significantly between groups (P > 0.05). Alzheimer's participants showed significantly decreased GC-IPL thickness over the inferior (P = 0.032) and inferonasal (P = 0.025) sectors compared with MCI and significantly decreased GC-IPL thickness over the entire (P = 0.012), superonasal (P = 0.041), inferior (P = 0.004), and inferonasal (P = 0.006) sectors compared to controls. MCI participants showed significantly decreased temporal RNFL thickness (P = 0.04) compared with controls. CONCLUSIONS: Alzheimer's participants showed significantly reduced macular VD, PD, and GC-IPL thickness compared with MCI and controls. Changes in the retinal microvasculature may mirror small vessel cerebrovascular changes in AD. SN - 2468-6530 UR - https://www.unboundmedicine.com/medline/citation/31174670/Retinal_Microvascular_and_Neurodegenerative_Changes_in_Alzheimer's_Disease_and_Mild_Cognitive_Impairment_Compared_with_Control_Participants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2468-6530(18)30669-9 DB - PRIME DP - Unbound Medicine ER -