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Metalloproteinases in nervous system function and pathology: introduction.
Cell Mol Life Sci. 2019 Aug; 76(16):3051-3053.CM

Abstract

This multi-author review in CMLS includes ten articles that provide an update of current knowledge on the role of metalloproteinases in the physiology and pathology of the central nervous system. The collection covers a wide range of situations in which matrix metalloproteinases, adamalysins and meprins are regulated and in turn regulate substrates or signalling pathways involved in: nervous system development, learning and memory, neuroinflammation, degeneration and repair after traumatic and ischemic injury or neurodegenerative mechanisms underlying retinopathies, psychiatric and neurodegenerative disorders. The authors also argue that these proteinases can be considered in some cases as biomarkers or potential therapeutic targets for diseases of the nervous system. Overall, metalloproteinases are placed among the key factors that can help us better understand the cellular and molecular processes that govern neuropathophysiology and implement the strategies that result from this knowledge to open up much-needed treatment opportunities.

Authors+Show Affiliations

Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France. santiago.rivera@univ-amu.fr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31175371

Citation

Rivera, Santiago. "Metalloproteinases in Nervous System Function and Pathology: Introduction." Cellular and Molecular Life Sciences : CMLS, vol. 76, no. 16, 2019, pp. 3051-3053.
Rivera S. Metalloproteinases in nervous system function and pathology: introduction. Cell Mol Life Sci. 2019;76(16):3051-3053.
Rivera, S. (2019). Metalloproteinases in nervous system function and pathology: introduction. Cellular and Molecular Life Sciences : CMLS, 76(16), 3051-3053. https://doi.org/10.1007/s00018-019-03172-8
Rivera S. Metalloproteinases in Nervous System Function and Pathology: Introduction. Cell Mol Life Sci. 2019;76(16):3051-3053. PubMed PMID: 31175371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metalloproteinases in nervous system function and pathology: introduction. A1 - Rivera,Santiago, Y1 - 2019/06/07/ PY - 2019/05/22/received PY - 2019/05/29/accepted PY - 2019/05/22/revised PY - 2019/6/9/pubmed PY - 2019/7/30/medline PY - 2019/6/9/entrez KW - ADAM KW - ADAMTS KW - CNS KW - MMP KW - Meprin KW - TIMP SP - 3051 EP - 3053 JF - Cellular and molecular life sciences : CMLS JO - Cell. Mol. Life Sci. VL - 76 IS - 16 N2 - This multi-author review in CMLS includes ten articles that provide an update of current knowledge on the role of metalloproteinases in the physiology and pathology of the central nervous system. The collection covers a wide range of situations in which matrix metalloproteinases, adamalysins and meprins are regulated and in turn regulate substrates or signalling pathways involved in: nervous system development, learning and memory, neuroinflammation, degeneration and repair after traumatic and ischemic injury or neurodegenerative mechanisms underlying retinopathies, psychiatric and neurodegenerative disorders. The authors also argue that these proteinases can be considered in some cases as biomarkers or potential therapeutic targets for diseases of the nervous system. Overall, metalloproteinases are placed among the key factors that can help us better understand the cellular and molecular processes that govern neuropathophysiology and implement the strategies that result from this knowledge to open up much-needed treatment opportunities. SN - 1420-9071 UR - https://www.unboundmedicine.com/medline/citation/31175371/Metalloproteinases_in_nervous_system_function_and_pathology:_introduction_ L2 - https://doi.org/10.1007/s00018-019-03172-8 DB - PRIME DP - Unbound Medicine ER -