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Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth.
Anticancer Res. 2019 Jun; 39(6):3185-3189.AR

Abstract

BACKGROUND

Bowel obstruction is commonly encountered in patients with advanced colorectal cancer; however, the cause of obstruction remains unknown. This study aimed to clarify a predictor of bowel obstruction due to colorectal cancer growth.

MATERIALS AND METHODS

Between January 2005 and December 2013, the medical records of 140 patients with T3 or T4 colorectal cancer who underwent curative resection (R0) at our Hospital were investigated retrospectively. This study consisted of 26 patients with obstructive colorectal cancer (OCC) and 114 patients with non-obstructive colon cancer (non-OCC).

RESULTS

Significant differences in clinicopathological factors including age, gender, T category, stage, primary tumor site, tumor diameter, macroscopic type, pathological type, lymphatic invasion, venous invasion, and lymph node metastasis were not observed between the two groups. Preoperative hematological/biochemical parameters including leukocyte count (p=0.004), neutrophil count (p=0.003), C-reactive protein (CRP) level (0.001), and neutrophil-to-lymphocyte ratio (NLR) (p=0.001) were significantly higher in the OCC group than in the non-OCC group. However, a significant difference in lymphocyte count was not observed between the two groups (p=0.634). Significant differences in the levels of the serum tumor markers CEA and CA19-9 were not observed between the two groups.

CONCLUSION

Preoperative NLR seems to be a useful predictor of bowel obstruction due to colorectal cancer growth.

Authors+Show Affiliations

Department of Surgery, Nishisaitama-chuo National Hospital, Saitama, Japan etoh.sei.ichiro51@gmail.com.Department of Surgery, Nishisaitama-chuo National Hospital, Saitama, Japan.Department of Surgery, Nishisaitama-chuo National Hospital, Saitama, Japan.Department of Surgery, Nishisaitama-chuo National Hospital, Saitama, Japan.Department of Surgery, Nishisaitama-chuo National Hospital, Saitama, Japan.Department of Surgery, Jikei University School of Medicine, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31177165

Citation

Eto, Seiichiro, et al. "Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth." Anticancer Research, vol. 39, no. 6, 2019, pp. 3185-3189.
Eto S, Kawahara H, Matsumoto T, et al. Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. Anticancer Res. 2019;39(6):3185-3189.
Eto, S., Kawahara, H., Matsumoto, T., Hirabayashi, T., Omura, N., & Yanaga, K. (2019). Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. Anticancer Research, 39(6), 3185-3189. https://doi.org/10.21873/anticanres.13456
Eto S, et al. Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. Anticancer Res. 2019;39(6):3185-3189. PubMed PMID: 31177165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative Neutrophil-Lymphocyte Ratio Is a Predictor of Bowel Obstruction Due to Colorectal Cancer Growth. AU - Eto,Seiichiro, AU - Kawahara,Hidejiro, AU - Matsumoto,Tomo, AU - Hirabayashi,Tsuyoshi, AU - Omura,Nobuo, AU - Yanaga,Katsuhiko, PY - 2019/04/05/received PY - 2019/05/13/revised PY - 2019/05/17/accepted PY - 2019/6/10/entrez PY - 2019/6/10/pubmed PY - 2019/6/18/medline KW - Bowel obstruction KW - colorectal cancer KW - neutrophil to lymphocyte ratio SP - 3185 EP - 3189 JF - Anticancer research JO - Anticancer Res. VL - 39 IS - 6 N2 - BACKGROUND: Bowel obstruction is commonly encountered in patients with advanced colorectal cancer; however, the cause of obstruction remains unknown. This study aimed to clarify a predictor of bowel obstruction due to colorectal cancer growth. MATERIALS AND METHODS: Between January 2005 and December 2013, the medical records of 140 patients with T3 or T4 colorectal cancer who underwent curative resection (R0) at our Hospital were investigated retrospectively. This study consisted of 26 patients with obstructive colorectal cancer (OCC) and 114 patients with non-obstructive colon cancer (non-OCC). RESULTS: Significant differences in clinicopathological factors including age, gender, T category, stage, primary tumor site, tumor diameter, macroscopic type, pathological type, lymphatic invasion, venous invasion, and lymph node metastasis were not observed between the two groups. Preoperative hematological/biochemical parameters including leukocyte count (p=0.004), neutrophil count (p=0.003), C-reactive protein (CRP) level (0.001), and neutrophil-to-lymphocyte ratio (NLR) (p=0.001) were significantly higher in the OCC group than in the non-OCC group. However, a significant difference in lymphocyte count was not observed between the two groups (p=0.634). Significant differences in the levels of the serum tumor markers CEA and CA19-9 were not observed between the two groups. CONCLUSION: Preoperative NLR seems to be a useful predictor of bowel obstruction due to colorectal cancer growth. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/31177165/Preoperative_Neutrophil_Lymphocyte_Ratio_Is_a_Predictor_of_Bowel_Obstruction_Due_to_Colorectal_Cancer_Growth_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=31177165 DB - PRIME DP - Unbound Medicine ER -