Tags

Type your tag names separated by a space and hit enter

Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan.
Ann Hematol. 2019 Aug; 98(8):1981-1987.AH

Abstract

Infection with Helicobacter pylori (H. pylori) is associated with an increased risk of gastric malignant lymphoma. The chronic inflammation of gastric mucosa by H. pylori infection induces lymphomagenesis. Although this chronic mucosal inflammation also results in atrophic gastritis, evidence supporting the possible significance of atrophic gastritis in gastric lymphomagenesis is scarce. Here, to evaluate the association between gastric mucosal atrophy and the risk of gastric lymphoma, we conducted a matched case-control study at Aichi Cancer Center focusing on the attribution of H. pylori infection status and pepsinogen (PG) serum levels. In total, 86 patients with gastric lymphoma (including 49 cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and 24 cases of diffuse large B cell lymphoma (DLBCL)) and 1720 non-cancer controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by conditional logistic regression analysis with adjustment for potential confounders. Results failed to show a statistically significant association between atrophic gastritis and the risk of gastric lymphoma. The adjusted ORs of positive atrophic gastritis relative to negative for overall gastric lymphoma, MALT lymphoma, DLBCL, and other lymphomas were 0.77 (95% CI 0.45-1.33), 0.65 (0.30-1.39), 1.03 (0.38-2.79), and 0.84 (0.22-3.29), respectively. In contrast, a positive association between overall gastric lymphoma and H. pylori infection was observed (OR = 2.14, 95% CI 1.30-3.54). A consistent association was observed for MALT lymphoma, DLBCL, and other lymphomas with ORs of 1.96 (1.00-3.86), 1.92 (0.74-4.95), and 5.80 (1.12-30.12), respectively. These findings suggest that H. pylori infection triggers gastric lymphoma but that epithelial changes due to atrophic gastritis do not inherently affect the development of gastric lymphoma.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan.Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. kmatsuo@aichi-cc.jp. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. kmatsuo@aichi-cc.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31177299

Citation

Ishikura, Naoyo, et al. "Helicobacter Pylori (HP) Infection Alone, but Not HP-induced Atrophic Gastritis, Increases the Risk of Gastric Lymphoma: a Case-control Study in Japan." Annals of Hematology, vol. 98, no. 8, 2019, pp. 1981-1987.
Ishikura N, Usui Y, Ito H, et al. Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. Ann Hematol. 2019;98(8):1981-1987.
Ishikura, N., Usui, Y., Ito, H., Kasugai, Y., Oze, I., Kato, S., Yatabe, Y., Nakamura, S., & Matsuo, K. (2019). Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. Annals of Hematology, 98(8), 1981-1987. https://doi.org/10.1007/s00277-019-03721-y
Ishikura N, et al. Helicobacter Pylori (HP) Infection Alone, but Not HP-induced Atrophic Gastritis, Increases the Risk of Gastric Lymphoma: a Case-control Study in Japan. Ann Hematol. 2019;98(8):1981-1987. PubMed PMID: 31177299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan. AU - Ishikura,Naoyo, AU - Usui,Yoshiaki, AU - Ito,Hidemi, AU - Kasugai,Yumiko, AU - Oze,Isao, AU - Kato,Seiichi, AU - Yatabe,Yasushi, AU - Nakamura,Shigeo, AU - Matsuo,Keitaro, Y1 - 2019/06/08/ PY - 2019/03/01/received PY - 2019/05/27/accepted PY - 2019/6/10/pubmed PY - 2019/7/26/medline PY - 2019/6/10/entrez KW - Atrophic gastritis KW - Case-control study KW - Gastric lymphoma KW - Helicobacter pylori KW - MALT lymphoma SP - 1981 EP - 1987 JF - Annals of hematology JO - Ann Hematol VL - 98 IS - 8 N2 - Infection with Helicobacter pylori (H. pylori) is associated with an increased risk of gastric malignant lymphoma. The chronic inflammation of gastric mucosa by H. pylori infection induces lymphomagenesis. Although this chronic mucosal inflammation also results in atrophic gastritis, evidence supporting the possible significance of atrophic gastritis in gastric lymphomagenesis is scarce. Here, to evaluate the association between gastric mucosal atrophy and the risk of gastric lymphoma, we conducted a matched case-control study at Aichi Cancer Center focusing on the attribution of H. pylori infection status and pepsinogen (PG) serum levels. In total, 86 patients with gastric lymphoma (including 49 cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and 24 cases of diffuse large B cell lymphoma (DLBCL)) and 1720 non-cancer controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by conditional logistic regression analysis with adjustment for potential confounders. Results failed to show a statistically significant association between atrophic gastritis and the risk of gastric lymphoma. The adjusted ORs of positive atrophic gastritis relative to negative for overall gastric lymphoma, MALT lymphoma, DLBCL, and other lymphomas were 0.77 (95% CI 0.45-1.33), 0.65 (0.30-1.39), 1.03 (0.38-2.79), and 0.84 (0.22-3.29), respectively. In contrast, a positive association between overall gastric lymphoma and H. pylori infection was observed (OR = 2.14, 95% CI 1.30-3.54). A consistent association was observed for MALT lymphoma, DLBCL, and other lymphomas with ORs of 1.96 (1.00-3.86), 1.92 (0.74-4.95), and 5.80 (1.12-30.12), respectively. These findings suggest that H. pylori infection triggers gastric lymphoma but that epithelial changes due to atrophic gastritis do not inherently affect the development of gastric lymphoma. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/31177299/Helicobacter_pylori__HP__infection_alone_but_not_HP_induced_atrophic_gastritis_increases_the_risk_of_gastric_lymphoma:_a_case_control_study_in_Japan_ L2 - https://dx.doi.org/10.1007/s00277-019-03721-y DB - PRIME DP - Unbound Medicine ER -