Tags

Type your tag names separated by a space and hit enter

The Role of Botulinum Toxin in the Treatment of Strabismus.

Abstract

Purpose:

To perform a systematic review of the application of botulinum toxin A (BTA) in the management of strabismus in the adult and pediatric populations. Materials and methods: A systematic literature search was performed using the Medline database.

Results:

In 1989, with the FDA approval of botulinum toxin (onabotulinum toxin A, or BTA) for the treatment of strabismus, patients were provided with an alternative to surgical recession. In this review, we discuss the uses of BTA in the treatment of acute onset comitant esotropia or smaller angle esotropia and as an adjunct to surgery for larger angle esotropia or sixth nerve palsy. Its uses are also explored in intermittent exotropia and vertical strabismus, including thyroid-associated orbitopathy, fourth nerve palsies, and other orbital pathology. Discussion: Despite its transient kinetics, BTA can have permanent effects on ocular alignment, promoting binocularity and reduction of diplopia, and can serve as a primary treatment or a muscle sparing option in patients at risk of anterior segment ischemia or need for future surgeries.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    a Department of Ophthalmology , Boston Children's Hospital , Boston , MA , USA.

    b Department of Ophthalmology , Harvard Medical School , Boston , MA , USA.

    Source

    Seminars in ophthalmology 34:4 2019 pg 198-204

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    31177893

    Citation

    Escuder, Anna G., and David G. Hunter. "The Role of Botulinum Toxin in the Treatment of Strabismus." Seminars in Ophthalmology, vol. 34, no. 4, 2019, pp. 198-204.
    Escuder AG, Hunter DG. The Role of Botulinum Toxin in the Treatment of Strabismus. Semin Ophthalmol. 2019;34(4):198-204.
    Escuder, A. G., & Hunter, D. G. (2019). The Role of Botulinum Toxin in the Treatment of Strabismus. Seminars in Ophthalmology, 34(4), pp. 198-204. doi:10.1080/08820538.2019.1620795.
    Escuder AG, Hunter DG. The Role of Botulinum Toxin in the Treatment of Strabismus. Semin Ophthalmol. 2019;34(4):198-204. PubMed PMID: 31177893.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Role of Botulinum Toxin in the Treatment of Strabismus. AU - Escuder,Anna G, AU - Hunter,David G, Y1 - 2019/06/08/ PY - 2019/6/11/pubmed PY - 2019/6/11/medline PY - 2019/6/11/entrez KW - Botox KW - Chemodenervation KW - Esotropia KW - Strabismus KW - botulinum toxin SP - 198 EP - 204 JF - Seminars in ophthalmology JO - Semin Ophthalmol VL - 34 IS - 4 N2 - Purpose: To perform a systematic review of the application of botulinum toxin A (BTA) in the management of strabismus in the adult and pediatric populations. Materials and methods: A systematic literature search was performed using the Medline database. Results: In 1989, with the FDA approval of botulinum toxin (onabotulinum toxin A, or BTA) for the treatment of strabismus, patients were provided with an alternative to surgical recession. In this review, we discuss the uses of BTA in the treatment of acute onset comitant esotropia or smaller angle esotropia and as an adjunct to surgery for larger angle esotropia or sixth nerve palsy. Its uses are also explored in intermittent exotropia and vertical strabismus, including thyroid-associated orbitopathy, fourth nerve palsies, and other orbital pathology. Discussion: Despite its transient kinetics, BTA can have permanent effects on ocular alignment, promoting binocularity and reduction of diplopia, and can serve as a primary treatment or a muscle sparing option in patients at risk of anterior segment ischemia or need for future surgeries. SN - 1744-5205 UR - https://www.unboundmedicine.com/medline/citation/31177893/The_Role_of_Botulinum_Toxin_in_the_Treatment_of_Strabismus L2 - http://www.tandfonline.com/doi/full/10.1080/08820538.2019.1620795 DB - PRIME DP - Unbound Medicine ER -