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Posttraumatic stress symptoms (PTSS) in patients with Cushing's disease before and after surgery: A prospective study.
J Clin Neurosci 2019; 66:1-6JC

Abstract

The aim of this study was to investigate the occurrence, correlated factors and prognosis of posttraumatic stress symptoms (PTSS) in patients with Cushing's disease (CD). A total of 49 patients who were newly diagnosed with CD and underwent transsphenoidal surgery in our hospital from April 2015 to August 2017 were asked to participate in this study. Another group of 49 age and sex matched healthy control participants were also included for comparison. PTSS (measured with Impact of Event Scale-Revised, IES-R), depression/anxiety (measured with Hospital Anxiety and Depression scale, HADS) and quality of life (QoL; measured with 36-item short-form, SF-36) were evaluated at pre-surgery, 6 months post-surgery and 12 months post-surgery. The results showed that at preoperative stage, 15 (30.6%) CD patients developed PTSS, and they had higher 24 h UFC, and presented worse levels of depression, anxiety and QoL compared with patients without PTSS. Although most of them recovered postoperatively, there were still 5/15 (33.3%) patients persisted with PTSS for over a year. Additionally, one patient with recurred CD developed PTSS between 6 and 12 months postoperatively. Among the whole group of CD patients, the PTSS severity showed consistent improvement after surgery, which was in accordance with the progressing trends of depression, anxiety and psychological aspects of SF-36. However, compared with healthy individuals, CD patients in remission still performed worse in physical/mental health. In conclusion, patients with CD can develop PTSS, and they may persist for over a year even after successful surgery. Combined psychological intervention is advised for these patients.

Authors+Show Affiliations

Department of Neurology, General Hospital of Southern Theatre Command, Guangzhou, China.Department of Neurology, General Hospital of Southern Theatre Command, Guangzhou, China.Department of Neurology, General Hospital of Southern Theatre Command, Guangzhou, China. Electronic address: jiang.c@vip.126.com.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31178305

Citation

Chen, Zhuang, et al. "Posttraumatic Stress Symptoms (PTSS) in Patients With Cushing's Disease Before and After Surgery: a Prospective Study." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 66, 2019, pp. 1-6.
Chen Z, Wang G, Jiang C. Posttraumatic stress symptoms (PTSS) in patients with Cushing's disease before and after surgery: A prospective study. J Clin Neurosci. 2019;66:1-6.
Chen, Z., Wang, G., & Jiang, C. (2019). Posttraumatic stress symptoms (PTSS) in patients with Cushing's disease before and after surgery: A prospective study. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 66, pp. 1-6. doi:10.1016/j.jocn.2019.05.059.
Chen Z, Wang G, Jiang C. Posttraumatic Stress Symptoms (PTSS) in Patients With Cushing's Disease Before and After Surgery: a Prospective Study. J Clin Neurosci. 2019;66:1-6. PubMed PMID: 31178305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posttraumatic stress symptoms (PTSS) in patients with Cushing's disease before and after surgery: A prospective study. AU - Chen,Zhuang, AU - Wang,Guoliang, AU - Jiang,Che, Y1 - 2019/06/06/ PY - 2018/12/24/received PY - 2019/04/13/revised PY - 2019/05/27/accepted PY - 2019/6/11/pubmed PY - 2019/10/30/medline PY - 2019/6/11/entrez KW - Cushing’s disease KW - Posttraumatic stress symptoms KW - Quality of life SP - 1 EP - 6 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 66 N2 - The aim of this study was to investigate the occurrence, correlated factors and prognosis of posttraumatic stress symptoms (PTSS) in patients with Cushing's disease (CD). A total of 49 patients who were newly diagnosed with CD and underwent transsphenoidal surgery in our hospital from April 2015 to August 2017 were asked to participate in this study. Another group of 49 age and sex matched healthy control participants were also included for comparison. PTSS (measured with Impact of Event Scale-Revised, IES-R), depression/anxiety (measured with Hospital Anxiety and Depression scale, HADS) and quality of life (QoL; measured with 36-item short-form, SF-36) were evaluated at pre-surgery, 6 months post-surgery and 12 months post-surgery. The results showed that at preoperative stage, 15 (30.6%) CD patients developed PTSS, and they had higher 24 h UFC, and presented worse levels of depression, anxiety and QoL compared with patients without PTSS. Although most of them recovered postoperatively, there were still 5/15 (33.3%) patients persisted with PTSS for over a year. Additionally, one patient with recurred CD developed PTSS between 6 and 12 months postoperatively. Among the whole group of CD patients, the PTSS severity showed consistent improvement after surgery, which was in accordance with the progressing trends of depression, anxiety and psychological aspects of SF-36. However, compared with healthy individuals, CD patients in remission still performed worse in physical/mental health. In conclusion, patients with CD can develop PTSS, and they may persist for over a year even after successful surgery. Combined psychological intervention is advised for these patients. SN - 1532-2653 UR - https://www.unboundmedicine.com/medline/citation/31178305/Posttraumatic_stress_symptoms__PTSS__in_patients_with_Cushing's_disease_before_and_after_surgery:_A_prospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(18)32240-9 DB - PRIME DP - Unbound Medicine ER -