Tags

Type your tag names separated by a space and hit enter

Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study.
J Dermatolog Treat. 2020 Nov; 31(7):739-743.JD

Abstract

Objective:

To assess the efficacy and safety of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis (RAS).

Methods:

Seventy-two subjects with RAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. The participants were randomly allocated to the test group or the control group. Demographic data were recorded at baseline. The use of the film was demonstrated. Pain score (visual analog scale), adverse effects, ulcer size were recorded on day 1 (baseline), day 2, day 4, and day 6.

Results:

The reduction in ulcer size was significantly greater (p<.05) in the treatment group (2.91 ± 3.66) than in the control group (1.10 ± 2.26) between days 4 and 6. There was no significant difference between the treatment and control groups in the pain score, ulcer size, or reduction in the pain score (p>.05). No obvious adverse effects were observed.

Conclusions:

The oral mucoadhesive film containing chitosan promotes oral ulcer healing and can be used as a drug carrier in treating oral ulcers.Trial registration number: ChiCTR-IOR-16008970.

Authors+Show Affiliations

Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China.Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31179773

Citation

Shao, Yanxiong, and Haiwen Zhou. "Clinical Evaluation of an Oral Mucoadhesive Film Containing Chitosan for the Treatment of Recurrent Aphthous Stomatitis: a Randomized, Double-blind Study." The Journal of Dermatological Treatment, vol. 31, no. 7, 2020, pp. 739-743.
Shao Y, Zhou H. Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. J Dermatolog Treat. 2020;31(7):739-743.
Shao, Y., & Zhou, H. (2020). Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. The Journal of Dermatological Treatment, 31(7), 739-743. https://doi.org/10.1080/09546634.2019.1610548
Shao Y, Zhou H. Clinical Evaluation of an Oral Mucoadhesive Film Containing Chitosan for the Treatment of Recurrent Aphthous Stomatitis: a Randomized, Double-blind Study. J Dermatolog Treat. 2020;31(7):739-743. PubMed PMID: 31179773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis: a randomized, double-blind study. AU - Shao,Yanxiong, AU - Zhou,Haiwen, Y1 - 2019/06/09/ PY - 2019/6/11/pubmed PY - 2019/6/11/medline PY - 2019/6/11/entrez KW - Recurrent aphthous stomatitis KW - chitosan KW - film SP - 739 EP - 743 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 31 IS - 7 N2 - Objective: To assess the efficacy and safety of an oral mucoadhesive film containing chitosan for the treatment of recurrent aphthous stomatitis (RAS).Methods: Seventy-two subjects with RAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. The participants were randomly allocated to the test group or the control group. Demographic data were recorded at baseline. The use of the film was demonstrated. Pain score (visual analog scale), adverse effects, ulcer size were recorded on day 1 (baseline), day 2, day 4, and day 6.Results: The reduction in ulcer size was significantly greater (p<.05) in the treatment group (2.91 ± 3.66) than in the control group (1.10 ± 2.26) between days 4 and 6. There was no significant difference between the treatment and control groups in the pain score, ulcer size, or reduction in the pain score (p>.05). No obvious adverse effects were observed.Conclusions: The oral mucoadhesive film containing chitosan promotes oral ulcer healing and can be used as a drug carrier in treating oral ulcers.Trial registration number: ChiCTR-IOR-16008970. SN - 1471-1753 UR - https://www.unboundmedicine.com/medline/citation/31179773/Clinical_evaluation_of_an_oral_mucoadhesive_film_containing_chitosan_for_the_treatment_of_recurrent_aphthous_stomatitis:_a_randomized_double_blind_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/09546634.2019.1610548 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.