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Screening for enteroviral meningitis in infants and children-Is it useful in clinical practice?
J Med Virol. 2019 10; 91(10):1882-1886.JM

Abstract

Enteroviral meningitis in infants and children commonly leads to hospital admission. Diagnosing viral meningitis can be difficult clinically. We examined the usefulness of enteroviral polymerase chain reaction (PCR) testing using cerebrospinal fluid (CSF) samples on clinical practice by comparing positive enteroviral CSF PCR cases (n = 39/136) to negative controls using both clinical outcomes and laboratory parameters. A positive result correlated with a reduced admission to high dependency unit, reduced the duration of antibiotics and a shorter length of stay (P < .05). Adjusted CSF white cell count > 5/μL correlated with positive PCR (P < .05) but would have missed 32% of cases of enteroviral meningitis. Following these findings, an algorithm for the management of suspected viral meningitis has been introduced.

Authors+Show Affiliations

Department of Medical Microbiology, Torbay Hospital, Torquay, United Kingdom.Medical School, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, United Kingdom. Department of Pediatrics, Torbay Hospital, Torquay, United Kingdom.Medical School, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, United Kingdom. Department of Pediatrics, Torbay Hospital, Torquay, United Kingdom.Medical School, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, United Kingdom. Department of Pediatrics, Torbay Hospital, Torquay, United Kingdom.Medical School, Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth, United Kingdom. Department of Pediatrics, Torbay Hospital, Torquay, United Kingdom.Department of Pediatrics, Torbay Hospital, Torquay, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31180138

Citation

Turner, Paul C., et al. "Screening for Enteroviral Meningitis in Infants and children-Is It Useful in Clinical Practice?" Journal of Medical Virology, vol. 91, no. 10, 2019, pp. 1882-1886.
Turner PC, Brayley J, Downing HC, et al. Screening for enteroviral meningitis in infants and children-Is it useful in clinical practice? J Med Virol. 2019;91(10):1882-1886.
Turner, P. C., Brayley, J., Downing, H. C., Homfray, G. J., Doolan, G., & Paul, S. P. (2019). Screening for enteroviral meningitis in infants and children-Is it useful in clinical practice? Journal of Medical Virology, 91(10), 1882-1886. https://doi.org/10.1002/jmv.25512
Turner PC, et al. Screening for Enteroviral Meningitis in Infants and children-Is It Useful in Clinical Practice. J Med Virol. 2019;91(10):1882-1886. PubMed PMID: 31180138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for enteroviral meningitis in infants and children-Is it useful in clinical practice? AU - Turner,Paul C, AU - Brayley,Jessica, AU - Downing,Hannah C, AU - Homfray,Gareth J, AU - Doolan,Georgia, AU - Paul,Siba P, Y1 - 2019/06/23/ PY - 2019/02/22/received PY - 2019/06/01/accepted PY - 2019/6/11/pubmed PY - 2020/7/3/medline PY - 2019/6/11/entrez KW - enterovirus < virus classification KW - generalized infection < pathogenesis KW - nervous system < pathogenesis SP - 1882 EP - 1886 JF - Journal of medical virology JO - J Med Virol VL - 91 IS - 10 N2 - Enteroviral meningitis in infants and children commonly leads to hospital admission. Diagnosing viral meningitis can be difficult clinically. We examined the usefulness of enteroviral polymerase chain reaction (PCR) testing using cerebrospinal fluid (CSF) samples on clinical practice by comparing positive enteroviral CSF PCR cases (n = 39/136) to negative controls using both clinical outcomes and laboratory parameters. A positive result correlated with a reduced admission to high dependency unit, reduced the duration of antibiotics and a shorter length of stay (P < .05). Adjusted CSF white cell count > 5/μL correlated with positive PCR (P < .05) but would have missed 32% of cases of enteroviral meningitis. Following these findings, an algorithm for the management of suspected viral meningitis has been introduced. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/31180138/Screening_for_enteroviral_meningitis_in_infants_and_children_Is_it_useful_in_clinical_practice L2 - https://doi.org/10.1002/jmv.25512 DB - PRIME DP - Unbound Medicine ER -