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Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software.
J Glaucoma 2019; 28(8):708-717JG

Abstract

PRéCIS:: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts.

PURPOSE

To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma.

PATIENTS AND METHODS

A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined.

RESULTS

Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001).

CONCLUSIONS

The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness.

Authors+Show Affiliations

Harvard Medical School. Department of Ophthalmology, University of California, San Francisco, San Francisco.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary.Harvard Medical School. Wellman Center for Photomedicine, Massachusetts General Hospital.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Beirut Eye and ENT Specialist Hospital, Saint-Joseph University Medical School, Beirut, Lebanon.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Department of Ophthalmology, Pamukkale University, School of Medicine, Denizli, Turkey.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Roski Eye Institute, University of Southern California.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary. Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.Harvard Medical School. Wellman Center for Photomedicine, Massachusetts General Hospital.Harvard Medical School. Wellman Center for Photomedicine, Massachusetts General Hospital.Department of Ophthalmology, Vrije Universiteit. Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands.Harvard Medical School. Department of Ophthalmology, Glaucoma Service, Massachusetts Eye, and Ear Infirmary.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31180936

Citation

Liu, Yingna, et al. "Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software." Journal of Glaucoma, vol. 28, no. 8, 2019, pp. 708-717.
Liu Y, Jassim F, Braaf B, et al. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. J Glaucoma. 2019;28(8):708-717.
Liu, Y., Jassim, F., Braaf, B., Khoueir, Z., Poon, L. Y., Ben-David, G. S., ... Chen, T. C. (2019). Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. Journal of Glaucoma, 28(8), pp. 708-717. doi:10.1097/IJG.0000000000001291.
Liu Y, et al. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. J Glaucoma. 2019;28(8):708-717. PubMed PMID: 31180936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software. AU - Liu,Yingna, AU - Jassim,Firas, AU - Braaf,Boy, AU - Khoueir,Ziad, AU - Poon,Linda Yi-Chieh, AU - Ben-David,Geulah S, AU - Papadogeorgou,Georgia, AU - Tsikata,Edem, AU - Simavli,Huseyin, AU - Que,Christian, AU - Lee,Ramon, AU - Shieh,Eric, AU - Vakoc,Benjamin J, AU - Bouma,Brett E, AU - de Boer,Johannes F, AU - Chen,Teresa C, PY - 2019/6/11/pubmed PY - 2019/6/11/medline PY - 2019/6/11/entrez SP - 708 EP - 717 JF - Journal of glaucoma JO - J. Glaucoma VL - 28 IS - 8 N2 - : PRéCIS:: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. PURPOSE: To compare the diagnostic capability of 3-dimensional peripapillary retinal volume (RV) versus 2-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma. PATIENTS AND METHODS: A retrospective cross-sectional analysis was conducted. A total of 180 subjects (113 open-angle glaucoma, 67 normal participants) had spectral domain optical coherence tomography volume scans and RNFL thickness measurements. Peripapillary RV values were calculated using a custom-designed program with 4 circumpapillary annuli (CA): CA1 had circle diameters of 2.5 and 3.5 mm; CA2, 3 and 4 mm; CA3, 3.5 and 4.5 mm; and CA4, 4 and 5 mm. Area under the receiver operating characteristic curves were calculated for global, quadrant, and octant regions for RV (CA1 to CA4) and RNFL thickness. Pair-wise comparisons were conducted. Artifacts rates were determined. RESULTS: Mean age was 62.7±15.4 years, and 47.8% (86/180) were male. Among RV measurements, best diagnostic performances were for the smallest 2 annuli for inferior RV (CA1: 0.964, CA2: 0.955). Of the 4 annuli, CA1 had the highest diagnostic performance. Of specific regions, the inferior RV quadrant had the highest performance across CA1 to CA4. Peripapillary RV had similar diagnostic capability compared with RNFL thickness (P>0.05). The artifact rate per B-scan for RV was 6.0%, which was significantly lower compared with 2-dimensional RNFL thickness in the same patient population (32.2%, P<0.0001). CONCLUSIONS: The diagnostic capability of RV is similar to RNFL thickness for perimetric open-angle glaucoma, but RV had fewer artifacts compared with RNFL thickness. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/31180936/Diagnostic_Capability_of_3D_Peripapillary_Retinal_Volume_for_Glaucoma_Using_Optical_Coherence_Tomography_Customized_Software L2 - http://Insights.ovid.com/pubmed?pmid=31180936 DB - PRIME DP - Unbound Medicine ER -