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Pregnancy outcomes and mother-to-child transmission rate in HTLV-1/2 infected women attending two public hospitals in the metropolitan area of Rio de Janeiro.
PLoS Negl Trop Dis 2019; 13(6):e0007404PN

Abstract

HTLV-1/2 are transmitted sexually, by whole cell blood products and from mother-to-child (MTC), mainly through breastfeeding. HTLV-1/2 prevalence in pregnant women is high in Rio de Janeiro, however there were no local studies addressing the rate of adverse pregnancy outcomes (APO) and MTC transmission. The aim was to study sociodemographic characteristics which may be associated to HTLV-1/2 infection and describe pregnancy outcomes and MTC transmission in HTLV-1/2-positive women. The cross-sectional study screened 1,628 pregnant women in of Rio de Janeiro (2012-2014) and found 12 asymptomatic carrier mothers (prevalence = 0.74%). Pregnancy outcome information was retrieved from medical records. Sociodemographic characteristics were similar between the positive and negative groups except for maternal age, which was higher in carrier mothers. The incidence of adverse pregnancy outcomes was similar in infected and non-infected patients (p = 0.33), however there was a high rate of premature rupture of membranes (PROM) amid infected mothers (3/12). Multilevel logistic regression found that for each additional year of age, the chance of being HTLV-1/2-positive increased 11% and that having another sexually transmitted infection (STI) increased 9 times the chance of being infected. Carrier mothers had more antenatal visits (OR = 5.26). Among the children of HTLV-1/2-positive mothers there was one fetal death, one infant death and one loss of follow-up. After two years of follow-up there was one case of MTC transmission (1/9). The mother reported breastfeeding for one month only. Knowledge about factors associated to HTLV-1/2 infection, its impact on pregnancy outcomes and the MTC transmission rate is important to guide public health policies on antenatal screening and management.

Authors+Show Affiliations

Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil. Department of Gynecology and Obstetrics, Centro Universitário Serra dos Órgãos (UNIFESO), Teresópolis, RJ, Brazil.Department of Internal Medicine, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Epidemiology, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil. Department of Epidemiology, Escola Nacional de Saúde Pública (Fiocruz), Rio de Janeiro, RJ, Brazil.Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil. Department of Gynecology and Obstetrics, Universidade Unigranrio, Rio de Janeiro, RJ, Brazil.Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Laboratory of Clinical Pathology, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Obstetrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Pediatrics, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.Department of Epidemiology, Escola Nacional de Saúde Pública (Fiocruz), Rio de Janeiro, RJ, Brazil. Department of Infectology, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31181057

Citation

Sodré Barmpas, Danielle Bittencourt, et al. "Pregnancy Outcomes and Mother-to-child Transmission Rate in HTLV-1/2 Infected Women Attending Two Public Hospitals in the Metropolitan Area of Rio De Janeiro." PLoS Neglected Tropical Diseases, vol. 13, no. 6, 2019, pp. e0007404.
Sodré Barmpas DB, Monteiro DLM, Taquette SR, et al. Pregnancy outcomes and mother-to-child transmission rate in HTLV-1/2 infected women attending two public hospitals in the metropolitan area of Rio de Janeiro. PLoS Negl Trop Dis. 2019;13(6):e0007404.
Sodré Barmpas, D. B., Monteiro, D. L. M., Taquette, S. R., Rodrigues, N. C. P., Trajano, A. J. B., Cunha, J. C., ... Bóia, M. N. (2019). Pregnancy outcomes and mother-to-child transmission rate in HTLV-1/2 infected women attending two public hospitals in the metropolitan area of Rio de Janeiro. PLoS Neglected Tropical Diseases, 13(6), pp. e0007404. doi:10.1371/journal.pntd.0007404.
Sodré Barmpas DB, et al. Pregnancy Outcomes and Mother-to-child Transmission Rate in HTLV-1/2 Infected Women Attending Two Public Hospitals in the Metropolitan Area of Rio De Janeiro. PLoS Negl Trop Dis. 2019;13(6):e0007404. PubMed PMID: 31181057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcomes and mother-to-child transmission rate in HTLV-1/2 infected women attending two public hospitals in the metropolitan area of Rio de Janeiro. AU - Sodré Barmpas,Danielle Bittencourt, AU - Monteiro,Denise Leite Maia, AU - Taquette,Stella Regina, AU - Rodrigues,Nádia Cristina Pinheiro, AU - Trajano,Alexandre José Baptista, AU - Cunha,Juliana de Castro, AU - Nunes,Camila Lattanzi, AU - Villela,Lucia Helena Cavalheiro, AU - Teixeira,Sérgio A M, AU - Sztajnbok,Denise Cardoso das Neves, AU - Bóia,Márcio Neves, Y1 - 2019/06/10/ PY - 2018/10/02/received PY - 2019/04/22/accepted PY - 2019/06/20/revised PY - 2019/6/11/pubmed PY - 2019/6/11/medline PY - 2019/6/11/entrez SP - e0007404 EP - e0007404 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 13 IS - 6 N2 - HTLV-1/2 are transmitted sexually, by whole cell blood products and from mother-to-child (MTC), mainly through breastfeeding. HTLV-1/2 prevalence in pregnant women is high in Rio de Janeiro, however there were no local studies addressing the rate of adverse pregnancy outcomes (APO) and MTC transmission. The aim was to study sociodemographic characteristics which may be associated to HTLV-1/2 infection and describe pregnancy outcomes and MTC transmission in HTLV-1/2-positive women. The cross-sectional study screened 1,628 pregnant women in of Rio de Janeiro (2012-2014) and found 12 asymptomatic carrier mothers (prevalence = 0.74%). Pregnancy outcome information was retrieved from medical records. Sociodemographic characteristics were similar between the positive and negative groups except for maternal age, which was higher in carrier mothers. The incidence of adverse pregnancy outcomes was similar in infected and non-infected patients (p = 0.33), however there was a high rate of premature rupture of membranes (PROM) amid infected mothers (3/12). Multilevel logistic regression found that for each additional year of age, the chance of being HTLV-1/2-positive increased 11% and that having another sexually transmitted infection (STI) increased 9 times the chance of being infected. Carrier mothers had more antenatal visits (OR = 5.26). Among the children of HTLV-1/2-positive mothers there was one fetal death, one infant death and one loss of follow-up. After two years of follow-up there was one case of MTC transmission (1/9). The mother reported breastfeeding for one month only. Knowledge about factors associated to HTLV-1/2 infection, its impact on pregnancy outcomes and the MTC transmission rate is important to guide public health policies on antenatal screening and management. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/31181057/Pregnancy_outcomes_and_mother-to-child_transmission_rate_in_HTLV-1/2_infected_women_attending_two_public_hospitals_in_the_metropolitan_area_of_Rio_de_Janeiro L2 - http://dx.plos.org/10.1371/journal.pntd.0007404 DB - PRIME DP - Unbound Medicine ER -