TY - JOUR T1 - Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer's Disease. A1 - Omar,Syed Haris, Y1 - 2019/06/07/ PY - 2019/05/18/received PY - 2019/06/05/revised PY - 2019/06/06/accepted PY - 2019/6/12/entrez PY - 2019/6/12/pubmed PY - 2019/11/19/medline KW - Alzheimer’s disease KW - Mediterranean diet KW - cognitive decline KW - olive biophenols JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 11 N2 - The risk of Alzheimer's disease (AD) increases with nonmodifiable conditions including age and lack of effective efficacious pharmacotherapy. During the past decades, the non-pharmacotherapy mode of treatment of dietary modification received extensive attention in AD research. In order to reduce the AD pathology and cognitive decline, various dietary patterns have been attempted including caloric restriction (CR), dietary approaches to stop hypertension (DASH), ketogenic diets (KD), Mediterranean diet (MedDi) and Mediterranean-DASH diet Intervention for Neurological Delay (MIND) diet. Higher adherence to the MedDi diet was associated with decreases in cardiovascular and neurological disorders including AD and related cognitive decline. However, another emerging healthy dietary pattern MIND diet has also been associated with slower rates of cognitive decline and significant reduction of AD rate. Olive serves as one of the building block components of MedDi and MIND diets and the exerted potential health beneficial might be suggested due to the presence of its bioactive constituents such as oleic acids and phenolic compounds (biophenols). A few trials using medical food showed an optimal result in presymptomatic or early stages of AD. The review supports the notion that MedDi and MIND diets display potential for maintaining the cognitive function as nonpharmacological agents against AD pathology and proposed preventative mechanism through the presence of olive biophenols and presents the gaps along with the future directions. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31181669/Mediterranean_and_MIND_Diets_Containing_Olive_Biophenols_Reduces_the_Prevalence_of_Alzheimer's_Disease_ L2 - https://www.mdpi.com/resolver?pii=ijms20112797 DB - PRIME DP - Unbound Medicine ER -