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Serological screening for coeliac disease in patients with juvenile idiopathic arthritis.
Arab J Gastroenterol 2019; 20(2):95-98AJ

Abstract

BACKGROUND AND STUDY AIMS

Juvenile idiopathic arthritis (JIA) is characterized by autoimmune aetiology. A gene locus 4q27 related to rheumatoid arthritis, psoriatic arthritis, and coeliac disease is associated with susceptibility to JIA. There are reports indicating several patients with JIA had been diagnosed with CD. We aimed to assess the frequency of coeliac disease (CD) in patients with juvenile idiopathic arthritis (JIA).

PATIENTS AND METHODS

This prospective study was carried out from October 2015 to August 2016 and included 96 patients with JIA. All patients were evaluated in terms of clinical and laboratory findings of CD. Levels of total IgA and tissue transglutaminase antibody (tTG) IgA were measured in all patients. Those with increased level of tTG IgA were further tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy were planned for a definite diagnosis of CD in patients with positive EMA.

RESULTS

Of the 96 patients in our study, 34 (35.4%) had oligoarticular form of JIA, 29 (30.2%) had polyarticular form, 12 (12.5%) had ERA form, 11 (11.5%) had systemic form, and 10 (10.4%) had psoriatic form. Sixteen of our patients (16.6%) were not using any drugs during the study. Neither EMA IgA antibodies were analysed nor gastro-duodenoscopy was performed because no patients were positive for tTG IgA. There was no difference in terms of tTG levels between the patients using NSAIDs or other drugs.

CONCLUSION

We did not find CD in children with JIA. Long term studies with more JIA patients are needed to provide more precise interpretation.

Authors+Show Affiliations

Department of Paediatric Gastroenterology, Cerrahpasa Medical School, Istanbul University, Turkey. Electronic address: ysahin977@gmail.com.Paediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Turkey.Paediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Turkey.Department of Paediatric Gastroenterology, Cerrahpasa Medical School, Istanbul University, Turkey.Department of Paediatric Gastroenterology, Cerrahpasa Medical School, Istanbul University, Turkey.Paediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Turkey.Department of Paediatric Gastroenterology, Cerrahpasa Medical School, Istanbul University, Turkey.Paediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31182344

Citation

Sahin, Yasin, et al. "Serological Screening for Coeliac Disease in Patients With Juvenile Idiopathic Arthritis." Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology, vol. 20, no. 2, 2019, pp. 95-98.
Sahin Y, Sahin S, Barut K, et al. Serological screening for coeliac disease in patients with juvenile idiopathic arthritis. Arab J Gastroenterol. 2019;20(2):95-98.
Sahin, Y., Sahin, S., Barut, K., Cokugras, F. C., Erkan, T., Adrovic, A., ... Kasapcopur, O. (2019). Serological screening for coeliac disease in patients with juvenile idiopathic arthritis. Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology, 20(2), pp. 95-98. doi:10.1016/j.ajg.2019.05.005.
Sahin Y, et al. Serological Screening for Coeliac Disease in Patients With Juvenile Idiopathic Arthritis. Arab J Gastroenterol. 2019;20(2):95-98. PubMed PMID: 31182344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological screening for coeliac disease in patients with juvenile idiopathic arthritis. AU - Sahin,Yasin, AU - Sahin,Sezgin, AU - Barut,Kenan, AU - Cokugras,Fugen Cullu, AU - Erkan,Tulay, AU - Adrovic,Amra, AU - Kutlu,Tufan, AU - Kasapcopur,Ozgur, Y1 - 2019/06/07/ PY - 2018/01/03/received PY - 2019/03/27/revised PY - 2019/05/26/accepted PY - 2019/6/12/pubmed PY - 2019/6/12/medline PY - 2019/6/12/entrez KW - Children KW - Coeliac disease KW - Juvenile idiopathic arthritis SP - 95 EP - 98 JF - Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology JO - Arab J Gastroenterol VL - 20 IS - 2 N2 - BACKGROUND AND STUDY AIMS: Juvenile idiopathic arthritis (JIA) is characterized by autoimmune aetiology. A gene locus 4q27 related to rheumatoid arthritis, psoriatic arthritis, and coeliac disease is associated with susceptibility to JIA. There are reports indicating several patients with JIA had been diagnosed with CD. We aimed to assess the frequency of coeliac disease (CD) in patients with juvenile idiopathic arthritis (JIA). PATIENTS AND METHODS: This prospective study was carried out from October 2015 to August 2016 and included 96 patients with JIA. All patients were evaluated in terms of clinical and laboratory findings of CD. Levels of total IgA and tissue transglutaminase antibody (tTG) IgA were measured in all patients. Those with increased level of tTG IgA were further tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy were planned for a definite diagnosis of CD in patients with positive EMA. RESULTS: Of the 96 patients in our study, 34 (35.4%) had oligoarticular form of JIA, 29 (30.2%) had polyarticular form, 12 (12.5%) had ERA form, 11 (11.5%) had systemic form, and 10 (10.4%) had psoriatic form. Sixteen of our patients (16.6%) were not using any drugs during the study. Neither EMA IgA antibodies were analysed nor gastro-duodenoscopy was performed because no patients were positive for tTG IgA. There was no difference in terms of tTG levels between the patients using NSAIDs or other drugs. CONCLUSION: We did not find CD in children with JIA. Long term studies with more JIA patients are needed to provide more precise interpretation. SN - 2090-2387 UR - https://www.unboundmedicine.com/medline/citation/31182344/Serological_screening_for_coeliac_disease_in_patients_with_juvenile_idiopathic_arthritis L2 - https://linkinghub.elsevier.com/retrieve/pii/S1687-1979(19)30048-6 DB - PRIME DP - Unbound Medicine ER -