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Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes.
Am J Hum Biol 2019; 31(4):e23272AJ

Abstract

OBJECTIVES

Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively).

METHODS

Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire.

RESULTS

Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 = .0140; P = .0082; β = .1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 = .170; P = .0103; β = .1291) and negatively with the occurrence of female osteoporosis (P = .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P = .0009).

CONCLUSIONS

Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.

Authors+Show Affiliations

School of Environmental & Life Sciences, University of Newcastle, Ourimbah, New South Wales, Australia.Nutraceuticals Research Group, University of Newcastle, Ourimbah, New South Wales, Australia.Nutraceuticals Research Group, University of Newcastle, Ourimbah, New South Wales, Australia.School of Environmental & Life Sciences, University of Newcastle, Ourimbah, New South Wales, Australia.School of Environmental & Life Sciences, University of Newcastle, Ourimbah, New South Wales, Australia.Maths & Physical Sciences, University of Newcastle, Ourimbah, New South Wales, Australia.Biomedical Sciences & Pharmacy, University of Newcastle, Ourimbah, New South Wales, Australia.Anthropology Department, 409 Carpenter Building, University Park, The Pennsylvania State University, Pennsylvania.Anthropology Department, 409 Carpenter Building, University Park, The Pennsylvania State University, Pennsylvania.Hull York Medical School, Heslington, UK.School of Environmental & Life Sciences, University of Newcastle, Ourimbah, New South Wales, Australia. Medicine & Public Health, University of Newcastle, Ourimbah, New South Wales, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31184412

Citation

Lucock, Mark, et al. "Early Lifecycle UV-exposure Calibrates Adult Vitamin D Metabolism: Evidence for a Developmentally Originated Vitamin D Homeostat That May Alter Related Adult Phenotypes." American Journal of Human Biology : the Official Journal of the Human Biology Council, vol. 31, no. 4, 2019, pp. e23272.
Lucock M, Thota R, Garg M, et al. Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. Am J Hum Biol. 2019;31(4):e23272.
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., ... Beckett, E. (2019). Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. American Journal of Human Biology : the Official Journal of the Human Biology Council, 31(4), pp. e23272. doi:10.1002/ajhb.23272.
Lucock M, et al. Early Lifecycle UV-exposure Calibrates Adult Vitamin D Metabolism: Evidence for a Developmentally Originated Vitamin D Homeostat That May Alter Related Adult Phenotypes. Am J Hum Biol. 2019;31(4):e23272. PubMed PMID: 31184412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early lifecycle UV-exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. AU - Lucock,Mark, AU - Thota,Rohith, AU - Garg,Manohar, AU - Martin,Charlotte, AU - Jones,Patrice, AU - Furst,John, AU - Yates,Zoe, AU - Jablonski,Nina G, AU - Chaplin,George, AU - Veysey,Martin, AU - Beckett,Emma, Y1 - 2019/06/11/ PY - 2018/11/20/received PY - 2019/03/04/revised PY - 2019/05/17/accepted PY - 2019/6/12/pubmed PY - 2019/6/12/medline PY - 2019/6/12/entrez SP - e23272 EP - e23272 JF - American journal of human biology : the official journal of the Human Biology Council JO - Am. J. Hum. Biol. VL - 31 IS - 4 N2 - OBJECTIVES: Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). METHODS: Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire. RESULTS: Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 = .0140; P = .0082; β = .1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 = .170; P = .0103; β = .1291) and negatively with the occurrence of female osteoporosis (P = .0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P = .0009). CONCLUSIONS: Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle. SN - 1520-6300 UR - https://www.unboundmedicine.com/medline/citation/31184412/Early_lifecycle_UV-exposure_calibrates_adult_vitamin_D_metabolism:_Evidence_for_a_developmentally_originated_vitamin_D_homeostat_that_may_alter_related_adult_phenotypes L2 - https://doi.org/10.1002/ajhb.23272 DB - PRIME DP - Unbound Medicine ER -