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Impact of well-controlled type 2 diabetes mellitus on implant stability and bone biomarkers.

Abstract

PURPOSE

To evaluate initial implant stability and initial healing around newly placed dental implants in well-controlled type 2 diabetes patients.

MATERIALS AND METHODS

Forty patients requiring implant therapy comprising 15 nondiabetic and 25 diabetic patients were recruited for this prospective study. Implant stability quotient and bone biomarkers such as osteopontin, receptor activator of nuclear factor-kB ligand, and interleukin 8 were evaluated at baseline and 1 and 3 months using Osstell Mentor and enzyme-linked immunosorbent assay, respectively.

RESULTS

Mean implant stability quotient values showed a statistically significant difference at each interval in both of the groups except between 1 and 3 months in the diabetic group. The percentage increase in implant stability quotient values was more in the nondiabetic (14.2%) than in the diabetic group (6.03%) from 1 to 3 months. Significant variations were observed in all three bone biomarkers between baseline and 3 months at P < .002 in both groups. In the diabetic group, receptor activator of nuclear factor-kB ligand showed a higher reduction from baseline to 3 months, whereas interleukin 8 showed a less significant decrease between baseline and 1 month. Changes in correlation between implant stability and bone biomarkers were noted in the initial period of healing between the two groups.

CONCLUSION

Variations in the pattern of response of osteopontin, receptor activator of nuclear factor-kB ligand, interleukin 8, and initial implant stability are noted in well-controlled diabetic individuals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31184637

Citation

Sundar, Gauthami, et al. "Impact of Well-controlled Type 2 Diabetes Mellitus On Implant Stability and Bone Biomarkers." The International Journal of Oral & Maxillofacial Implants, 2019.
Sundar G, Sridharan S, Sundaram RR, et al. Impact of well-controlled type 2 diabetes mellitus on implant stability and bone biomarkers. Int J Oral Maxillofac Implants. 2019.
Sundar, G., Sridharan, S., Sundaram, R. R., Prabhu, S., Rao, R., & Rudresh, V. (2019). Impact of well-controlled type 2 diabetes mellitus on implant stability and bone biomarkers. The International Journal of Oral & Maxillofacial Implants, doi:10.11607/jomi.7547.
Sundar G, et al. Impact of Well-controlled Type 2 Diabetes Mellitus On Implant Stability and Bone Biomarkers. Int J Oral Maxillofac Implants. 2019 Jun 1; PubMed PMID: 31184637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of well-controlled type 2 diabetes mellitus on implant stability and bone biomarkers. AU - Sundar,Gauthami, AU - Sridharan,Srirangarajan, AU - Sundaram,R R, AU - Prabhu,Srikumar, AU - Rao,Ravi, AU - Rudresh,Vinaya, Y1 - 2019/06/01/ PY - 2019/6/12/entrez JF - The International journal of oral & maxillofacial implants JO - Int J Oral Maxillofac Implants N2 - PURPOSE: To evaluate initial implant stability and initial healing around newly placed dental implants in well-controlled type 2 diabetes patients. MATERIALS AND METHODS: Forty patients requiring implant therapy comprising 15 nondiabetic and 25 diabetic patients were recruited for this prospective study. Implant stability quotient and bone biomarkers such as osteopontin, receptor activator of nuclear factor-kB ligand, and interleukin 8 were evaluated at baseline and 1 and 3 months using Osstell Mentor and enzyme-linked immunosorbent assay, respectively. RESULTS: Mean implant stability quotient values showed a statistically significant difference at each interval in both of the groups except between 1 and 3 months in the diabetic group. The percentage increase in implant stability quotient values was more in the nondiabetic (14.2%) than in the diabetic group (6.03%) from 1 to 3 months. Significant variations were observed in all three bone biomarkers between baseline and 3 months at P < .002 in both groups. In the diabetic group, receptor activator of nuclear factor-kB ligand showed a higher reduction from baseline to 3 months, whereas interleukin 8 showed a less significant decrease between baseline and 1 month. Changes in correlation between implant stability and bone biomarkers were noted in the initial period of healing between the two groups. CONCLUSION: Variations in the pattern of response of osteopontin, receptor activator of nuclear factor-kB ligand, interleukin 8, and initial implant stability are noted in well-controlled diabetic individuals. SN - 1942-4434 UR - https://www.unboundmedicine.com/medline/citation/31184637/Impact_of_well-controlled_type_2_diabetes_mellitus_on_implant_stability_and_bone_biomarkers L2 - https://doi.org/10.11607/jomi.7547 DB - PRIME DP - Unbound Medicine ER -