Tags

Type your tag names separated by a space and hit enter

Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia.

Abstract

BACKGROUND

Inflammation and vaso-occlusion play key roles in Sickle Cell Disease (SCD) pathophysiology. Lipoxygenase products of the omega-3 fatty acids (O3FAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are potent anti-inflammatory mediators modulating pain. O3FAs decrease episodes of vaso-occlusion in SCD.

METHODS

We assessed erythrocyte fatty acid composition in two major cell membrane phospholipids, phosphatidylcholine and phosphatidylethanolamine, in children with SCD HbSS-disease (n = 38) and age/race-matched HbAA-controls (n = 18). Ratio of pro-inflammatory arachidonic acid (AA) to anti-inflammatory DHA and EPA (FA-Ratio), and its relationship to hs-CRP were evaluated.

RESULTS

FA-Ratios were increased in both phosphatidylcholine and phosphatidylethanolamine in HbSS compared to controls. Correlations were noted in HbSS subjects between hs-CRP and FA-Ratios (p = 0.011). FA-Ratios increased with age (p = 0.0007) due to an increase in pro-inflammatory AA with a concomitant decrease in anti-inflammatory DHA.

CONCLUSIONS

Findings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP.

Authors+Show Affiliations

Marian Anderson Sickle Cell Research Center, Department of Pediatrics, Thomas Jefferson University Medical School, Philadelphia, PA, United States; Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, United States. Electronic address: yamaja.setty@nemours.org.Marian Anderson Sickle Cell Research Center, Department of Pediatrics, Thomas Jefferson University Medical School, Philadelphia, PA, United States; Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, United States.Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, United States.Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, United States.Division of Hematology, St Christopher's Hospital for Children, Drexel University School of Medicine, Philadelphia, PA, United States.Division of Hematology, St Christopher's Hospital for Children, Drexel University School of Medicine, Philadelphia, PA, United States.Division of Hematology, St Christopher's Hospital for Children, Drexel University School of Medicine, Philadelphia, PA, United States.Division of Hematology, St Christopher's Hospital for Children, Drexel University School of Medicine, Philadelphia, PA, United States.Marian Anderson Sickle Cell Research Center, Department of Pediatrics, Thomas Jefferson University Medical School, Philadelphia, PA, United States; Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31186149

Citation

Setty, B N Yamaja, et al. "Relationship of Omega-3 Fatty Acids DHA and EPA With the Inflammatory Biomarker hs-CRP in Children With Sickle Cell Anemia." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 146, 2019, pp. 11-18.
Setty BNY, Betal SG, Miller RE, et al. Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia. Prostaglandins Leukot Essent Fatty Acids. 2019;146:11-18.
Setty, B. N. Y., Betal, S. G., Miller, R. E., Brown, D. S., Meier, M., Cahill, M., Lerner, N. B., Apollonsky, N., & Stuart, M. J. (2019). Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 146, 11-18. https://doi.org/10.1016/j.plefa.2019.05.004
Setty BNY, et al. Relationship of Omega-3 Fatty Acids DHA and EPA With the Inflammatory Biomarker hs-CRP in Children With Sickle Cell Anemia. Prostaglandins Leukot Essent Fatty Acids. 2019;146:11-18. PubMed PMID: 31186149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia. AU - Setty,B N Yamaja, AU - Betal,Suhita Gayen, AU - Miller,Robin E, AU - Brown,Dawn S, AU - Meier,Maureen, AU - Cahill,Michele, AU - Lerner,Norma B, AU - Apollonsky,Nataly, AU - Stuart,Marie J, Y1 - 2019/05/10/ PY - 2019/02/15/received PY - 2019/05/09/revised PY - 2019/05/09/accepted PY - 2019/6/13/entrez PY - 2019/6/13/pubmed PY - 2020/4/28/medline KW - C-reactive protein KW - Docosahexaenoic acid KW - Inflammatory biomarkers KW - Omega-3 fatty acids KW - Polyunsaturated fatty acids KW - Sickle cell anemia SP - 11 EP - 18 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 146 N2 - BACKGROUND: Inflammation and vaso-occlusion play key roles in Sickle Cell Disease (SCD) pathophysiology. Lipoxygenase products of the omega-3 fatty acids (O3FAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are potent anti-inflammatory mediators modulating pain. O3FAs decrease episodes of vaso-occlusion in SCD. METHODS: We assessed erythrocyte fatty acid composition in two major cell membrane phospholipids, phosphatidylcholine and phosphatidylethanolamine, in children with SCD HbSS-disease (n = 38) and age/race-matched HbAA-controls (n = 18). Ratio of pro-inflammatory arachidonic acid (AA) to anti-inflammatory DHA and EPA (FA-Ratio), and its relationship to hs-CRP were evaluated. RESULTS: FA-Ratios were increased in both phosphatidylcholine and phosphatidylethanolamine in HbSS compared to controls. Correlations were noted in HbSS subjects between hs-CRP and FA-Ratios (p = 0.011). FA-Ratios increased with age (p = 0.0007) due to an increase in pro-inflammatory AA with a concomitant decrease in anti-inflammatory DHA. CONCLUSIONS: Findings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/31186149/Relationship_of_Omega_3_fatty_acids_DHA_and_EPA_with_the_inflammatory_biomarker_hs_CRP_in_children_with_sickle_cell_anemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(19)30016-X DB - PRIME DP - Unbound Medicine ER -