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High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review.
Nutr Clin Pract 2019; 34(4):514-520NC

Abstract

Vasodilatory shock, as observed in postoperative states and sepsis, is hallmarked by low systemic vascular resistance and low blood pressure compensated by increased cardiac output. Gasotransmitters, such as nitric oxide and hydrogen sulfide, are implicated in the development and perpetuation of vasodilatory shock. Established therapies do not target these physiologic drivers of vasodilation. Due to their nontoxic and pleotropic effects, micronutrients are being used as rescue therapy in postoperative vasoplegia and septic shock. Here, we outline the pathophysiology of vasodilatory shock, describe the rationale for vitamin B12 (hydroxocobalamin) in vasodilatory shock, and identify literature evaluating its use in vasoplegic states.

Authors+Show Affiliations

Division of Pulmonary & Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA.Division of Pediatric Infectious Disease, Children's Hospital of Wisconsin and the Medical College of Wisconsin, Milwaukee, WI, USA.Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA. Division of Cardiac Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31187494

Citation

Patel, Jayshil J., et al. "High-Dose Vitamin B12 in Vasodilatory Shock: a Narrative Review." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 34, no. 4, 2019, pp. 514-520.
Patel JJ, Venegas-Borsellino C, Willoughby R, et al. High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review. Nutr Clin Pract. 2019;34(4):514-520.
Patel, J. J., Venegas-Borsellino, C., Willoughby, R., & Freed, J. K. (2019). High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 34(4), pp. 514-520. doi:10.1002/ncp.10327.
Patel JJ, et al. High-Dose Vitamin B12 in Vasodilatory Shock: a Narrative Review. Nutr Clin Pract. 2019;34(4):514-520. PubMed PMID: 31187494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review. AU - Patel,Jayshil J, AU - Venegas-Borsellino,Carla, AU - Willoughby,Rodney, AU - Freed,Julie K, Y1 - 2019/06/12/ PY - 2019/6/13/pubmed PY - 2019/6/13/medline PY - 2019/6/13/entrez KW - gasotransmitters KW - hydroxocobalamin KW - sepsis KW - shock KW - systemic vascular resistance KW - vasoplegia KW - vitamin B12 SP - 514 EP - 520 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 34 IS - 4 N2 - Vasodilatory shock, as observed in postoperative states and sepsis, is hallmarked by low systemic vascular resistance and low blood pressure compensated by increased cardiac output. Gasotransmitters, such as nitric oxide and hydrogen sulfide, are implicated in the development and perpetuation of vasodilatory shock. Established therapies do not target these physiologic drivers of vasodilation. Due to their nontoxic and pleotropic effects, micronutrients are being used as rescue therapy in postoperative vasoplegia and septic shock. Here, we outline the pathophysiology of vasodilatory shock, describe the rationale for vitamin B12 (hydroxocobalamin) in vasodilatory shock, and identify literature evaluating its use in vasoplegic states. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/31187494/High-Dose_Vitamin_B12_in_Vasodilatory_Shock:_A_Narrative_Review L2 - https://doi.org/10.1002/ncp.10327 DB - PRIME DP - Unbound Medicine ER -